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Cigarette smoke is a strong risk factor for cardiovascular disease. However, the underlying molecular mechanisms that lead to cigarette smoke-associated cardiovascular disease remain elusive. With functional and molecular methods, we demonstrate for the first time that lipid soluble cigarette smoke particles (DSP) increased the expression of endothelin type B (ET(B)) receptors in arterial smooth m

This paper describes the characterisation of an ultra-thin silicon semicondoctor Delta E detector to be used as a pre-cell ion hit detector in single ion experiments on individual, living cells. The characteristics of interest for this specific application are the hit detection efficiency, which has to be close to 100% to enable bombardment with either a single ion or a counted number of ions, the

Förra året beslutade SLF att 'adoptera' Skäckerfjällen i Jämtland, vilket innebär att föreningen avser att göra en fullständig inventering av dess lavar genom återkommande besök under ett antal år. Första besöket gjordes under höstexkursionen 2008 i mångahanda spännande miljöer, såsom kalkbranter, bäckraviner med gammal granskog, videsnår, snölegor och fjälltoppar med urberg. Exkursionen resultera

We consider the problem of localizing a novel image in a large 3D model. In principle, this is just an instance of camera pose estimation, but the scale introduces some challenging problems. For one, it makes the correspondence problem very difficult and it is likely that there will be a significant rate of outliers to handle. In this paper we use recent theoretical as well as technical advances t

Markers of mercury (Hg) exposure have shown both positive and negative associations with cardiovascular disease (CVD). We assessed the association between serum Hg (S-Hg) and risk of cardiovascular disease in a prospective population-based cohort, with attention to the roles of dental health and fish consumption. Total mortality, as well as morbidity and mortality from acute myocardial infarction

Introduction. We aim to create an in-depth understanding of how pupils in upper secondary school negotiate the credibility and authority of information as part of their practices of learning. Particular focus is on the use of user-created resources, such as Wikipedia, where authorship is collective and/or hard to determine. Method. An ethnographic study was conducted in an upper secondary school c

Glioblastoma Multiforme (GBM) is the most abundant and most aggressive primary brain tumor in adults. Due to the infiltrative growth of the tumor, surgery will never be radical. Radiation and chemotherapy only marginally improve the poor prognosis due to the ability of the GBM to develop resistance towards these treatments. Therefore it is of great importance to find new efficient treatment modali

The use of acoustic forces to manipulate particles or cells at the microfluidic scale (i.e. acoustophoresis), enables non-contact, label-free separation based on intrinsic cell properties such as size, density and compressibility. Acoustophoresis holds great promise as a cell separation technique in several research and clinical areas. However, it has been suggested that the force acting upon cell

Massive MIMO, also known as very-large MIMO or large-scale antenna systems, is a new technique that potentially can offer large network capacities in multi-user scenarios. With a massive MIMO system, we consider the case where a base station equipped with a large number of antenna elements simultaneously serves multiple single-antenna users in the same time-frequency resource. So far, investigatio

Lactococcus garvieae is a rare cause of infective endocarditis (IE) in humans and the bacterium can easily be misidentified. Intracranial haemorrhage often occurs in conjunction with IE, but subdural haemorrhage (SDH) is very rarely encountered.

We aim to provide a long-term ecological analysis of land-use and floristic diversity in the transition from traditional to modern land-use management in the time a.d. 1800-2008 in southern Sweden. We use the Regional Estimates of Vegetation Abundance from Large Sites (REVEALS) model to quantify land-cover changes on a regional scale at 20-year intervals, based on the fossil pollen record. Florist

Migration is an important event in many animal life histories, but the degree to which individual animals participate in seasonal migrations often varies within populations. The powerful ecological and evolutionary consequences of such partial migration are now well documented, but the underlying mechanisms are still heavily debated. One potential mechanism of partial migration is between-individu

Nutrient reduction and the improvement of bottom water oxygen concentrations are thought to be key factors in the recovery of eutrophic aquatic ecosystems. The effects of re oxygenation and bioturbation of natural hypoxic sediments in the Baltic Sea were studied using a mesocosm experiment. Anoxic sediment box cores were collected from 100 m depth in Kanholmsfj rden (Stockholm Archipelago) and mai

The management of minor and moderate head trauma in children differs widely between countries. Presently, there are no existing guidelines for management of these children in Scandinavia. The purpose of this study was to produce new evidence-based guidelines for the initial management of head trauma in the paediatric population in Scandinavia. The primary aim was to detect all children in need of

The crystal structures of three conformations, T6, T3R3 and R6, of bovine insulin were solved at 1.40, 1.30 and 1.80 angstrom resolution, respectively. All conformations crystallized in space group R3. In contrast to the T6 and T3R3 structures, different conformations of the N-terminal B-chain residue PheB1 were observed in the R6 insulin structure, resulting in an eightfold doubling of the unit-c

Background. Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous group of B-cell lymphomas. Five clinical adverse risk factors are merged into the International Prognostic Index (IPI), which is the major tool for prognostication. In contrast to Hodgkin's lymphoma, gender is not considered as an adverse risk factor for DLBCL patients. As we clinically had observed a very good survival rate in y