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Abstract Objective. To evaluate the diagnostic utility of single-operator peroral cholangioscopy (SOC) in patients with sclerosing cholangitis. Methods. All patients with sclerosing cholangitis who underwent SOC procedures due to suspicious biliary strictures, in one Swedish and four UK tertiary centers in 2008-2012, were retrospectively enrolled. For each SOC procedure in sclerosing cholangitis,
Background: Individuals with Williams syndrome, a rare genetic disorder, are characterized by specific medical, cognitive, and behavioral phenotypes and often have high anxiety levels as well as phobia. Studies of the psychiatric phenotype in adults affected by Williams syndrome or literature on the management of their mental pathologies are lacking. Method: In this article, we report the neuropsy
Food caching is a paramount model for studying relations between cognition, brain organisation and ecology in corvids. In contrast, behaviour towards inedible objects is poorly examined and understood. We review the literature on object caching in corvids and other birds, and describe an exploratory study on object caching in ravens, New Caledonian crows and jackdaws. The captive adult birds were
Circular orientation cages have been used for several decades to record the migratory orientation of passerine migrants, and have been central to the investigation of the functional characteristics of the biological compasses used for orientation. The use of these cages offers unique possibilities to study the migratory behaviour of songbirds, but suffers from statistical limitations in evaluating
Objective: To relate Doppler velocimetry findings in fetoplacental and uteroplacental circulation to placental histomorphology. Material and methods: In 14 uncomplicated and 31 high-risk pregnancies Doppler velocimetry was performed in umbilical artery and vein, and in maternal uterine veins and arteries during the second half of gestation. Histopathology of the placentas was examined, especially
Egress model developers are in a difficult position. It is in their interest to develop models that are simplified representations of reality and at the same time reduce inadvertent misuse. While default values enable immediate (i.e. out-of-the-box) use of models without in-depth familiarization with modelling assumptions, defaults often represent optimistic and/or even unrealistic evacuee behavio
Recursively compressed inverse preconditioning (RCIP) is a numerical method for obtaining highly accurate solutions to integral equations on piecewise smooth surfaces. The method originated in 2008 as a technique within a scheme for solving Laplace’s equation in two-dimensional domains with corners. In a series of subsequent papers, the technique was then refined and extended as to apply to integr
The phospholipid fatty acid (PLFA) pattern of vineyard soils from the Northwest of the Iberian Peninsula was studied to identify soil factors determining the microbial community structure, with special emphasis on effects of Cu pollution and pH. A wide range of soil samples, collected from six winegrowing regions (Rias Baixas, Ribeiro, Ribeira Sacra, Monterrei, Valdeorras and Vinhos Verdes) was an
Though activation of Broca's region in the combinatorial processing of symbols (language, music) has been revealed by neurometabolic studies, most previous neurophysiological research found the earliest grammar indices in the temporal cortex, with inferior-frontal generators becoming active at relatively late stages. We use the attention- and task-free syntactic mismatch negativity (sMMN) event-re
What are the effects of liraglutide, an incretin based treatment, on glycaemic control in people with type 2 diabetes treated with multiple daily insulin injections?
The cytoplasmic phosphatase PTPN22 (protein tyrosine phosphatase nonreceptor type 22) plays a key role in regulating lymphocyte homeostasis, which ensures that the total number of lymphocytes in the periphery remains relatively constant. Mutations in PTPN22 confer an increased risk of developing autoimmune diseases; however, the precise function of PTPN22 and how mutations contribute to auto-immun
Phase behavior of the three components, 1-propanol, water and oil is studied at 10, 25, and 40°C. Biodiesel, limonene and diesel are used as oil phases. NMR self-diffusion measurements are performed to investigate the microstructure of the one-phase regions. Tie lines in the two-phase regions are determined both by proton NMR analysis and compared with theoretical calculations. NMR self-diffusion
A brief overview of hexagonal superstructures with a periodicity of similar to 3 nm formed on Ru(0001) and Ge(111) by graphene or hexagonal boron nitride with a thickness of just a single atomic layer is given. A periodic height corrugation of such layers due to the lattice mismatch with the substrate material is of the order of 0.1 nm. Selected examples of scanning tunneling microscopy (STM) and
Solid oxide fuel cells (SOFCs) are widely studied for their advantages especially at high temperatures. However, operating at high temperatures represents a high cost due to the strict requirements the materials are expected to fulfill. Thus, the main goal in SOFC research has been to decrease the operating temperature so that the range of available materials is widened and hence, the operating co
Glucose lowering therapy in type 1 and type 2 diabetes is often associated with hypoglycemic events. To avoid this, glucose lowering therapies need to be developed that support the hypoglycemic defense mechanisms. Such development needs a tool for evaluating counterregulatory mechanisms in vivo. A sustained glucagon release during hypoglycemia is of most importance to hypoglycemic defense mechanis
The positron emission tomography (PET)/computed tomography (CT) camera is a combination of a PET camera and a CT. The image from the PET camera is based on the detection of radiation that is emitted from a radioactive tracer, which has been given to the patient as an intravenous injection. The radiation that is emitted from the radioactive tracer is more energetic than any other radiation used in
We have developed the novel Aerosol Dynamics, gas- and particle-phase chemistry model for laboratory CHAMber studies (ADCHAM). The model combines the detailed gas-phase Master Chemical Mechanism version 3.2 (MCMv3.2), an aerosol dynamics and particle-phase chemistry module (which considers acid-catalysed oligomerization, heterogeneous oxidation reactions in the particle phase and non-ideal interac
High-resolution spectral Doppler is an important and pow- erful non-invasive tool for estimation of velocities in blood vessels using medical ultrasound scanners. Such estimates are typically formed using an averaged periodogram technique, resulting in well-known limitations in the resulting spectral resolution. Recently, we have proposed tech- niques to instead form high-resolution data-adaptive
