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Objectives To perform fine mapping of the PXK locus associated with systemic lupus erythematosus (SLE) and study functional effects that lead to susceptibility to the disease. Methods Linkage disequilibrium (LD) mapping was conducted by using 1251 SNPs (single nucleotide polymorphism) covering a 862 kb genomic region on 3p14.3 comprising the PXK locus in 1467 SLE patients and 2377 controls of Euro
The laws of fluid dynamics govern vortex ring formation and precede cardiac development by billions of years, suggesting that diastolic vortex ring formation is instrumental in defining the shape of the heart. Using novel and validated magnetic resonance imaging measurements, we show that the healthy left ventricle moves in tandem with the expanding vortex ring, indicating that cardiac form and fu
Animal flight performance has been studied using models developed for man-made aircraft. For an aeroplane with fixed wings, the energetic cost as a function of flight speed can be expressed in terms of weight, wing span, wing area and body area, where more details are included in proportionality coefficients. Flying animals flap their wings to produce thrust. Adopting the fixed wing flight model i
Monitoring of glucose in subcutaneous and brain striatum have been extensively studied in the past. While biocompatibility was one of the limitations, others included the messy measuring equipments preclude monitoring in a complex environment. This study tried to establish an amperometric measurement of glucose in pre- and post-insulin-administration on diabetic and hyperglycemia rats via wireless
Two compounds, [Cu5I5](SNC5H4)2 [i] and [Cu3I3](SNC5H4)2 [ii], were synthesized under hydrothermal conditions and the crystal structures were solved. Both compounds crystallized in space group 141/a. The iodide and the sulphur from mercaptopyridine are connected to copper atom, giving the copper atoms tetrahedral coordination geometry. The pyridine end of the organic moiety is non-bonding and fill
Popular Abstract in Swedish Osteoporos (benskörhet) är ett tillstånd som definieras av låg benmassa och ett tillstånd som ökar med stigande ålder. Sjukdomen i sig är symptomfri men ökar risken för frakturer. Frakturer i kota, axel, handled, bäcken, och höft efter 50 års ålder är ofta förknippade med osteoporos och ca 70 000 sådana frakturer inträffar årligen i Sverige. Även artros (ledsvikt) i höfPartly due to an ageing population, the number of osteoporosis-related fractures and osteoarthritis (OA)-related hip and knee arthroplasty procedures is increasing. The individual suffering and the burden on society for these conditions is immense. Genetic contribution for the variance in bone mineral density (BMD) is estimated at around 60–80%, and for OA 50%, leaving a considerable proportion to
Progressive supranuclear palsy (PSP) is a neurodegenerative disease characterized by gait and postural disturbance, gaze palsy, apathy, decreased verbal fluency and dysexecutive symptoms, with some of these clinical features potentially having origins in degeneration of frontostriatal circuits and the mesencephalon. This hypothesis was investigated by manual segmentation of the caudate and putamen
Background: Type 2 diabetes is associated with obesity, ectopic lipid accumulation and low-grade inflammation. A dysfunctional gut microbiota has been suggested to participate in the pathogenesis of the disease. Green tea is rich in polyphenols and has previously been shown to exert beneficial metabolic effects. Lactobacillus plantarum has the ability to metabolize phenolic acids. The health promo
Dampness in indoor environments may cause various health problems. The specific causative agent(s) are unknown but may originate from degradation processes in damp materials, microbial growth, or a combination of these phenomena. The health impact of dampness in buildings is a politically, legally, and economically important question. Scientists at the U.S. EPA and Lawrence Berkeley National Labor
In this paper, we present a monitoring assisted robust routing scheme for wireless mesh networks which exploits the broadcast nature of wireless transmissions at special routers with added monitoring functionalities. These routers passively listen to the transmissions in their neighborhood and compare the routing behavior against the routing state collectively maintained by them. If any inconsiste
Monitoring low molecular weight heparins (LMWH's) in the perioperative period is prudent in patients at high risk of coagulative complications, especially when the patient has an epidural catheter requiring withdrawal, which is associated with the risk of spinal haematoma. The aim of this study was to evaluate the in vitro dose-responses of two different LMWH's on two different viscoelastic haemos
In this contribution, a micro-mechanically motivated, energy relaxation-based constitutive model for phase transformation, martensite reorientation and twin formation in shape memory alloys is proposed. The formulation builds on an idealized parametrization of the austenite-twinned martensite microstructure through first- and second-order laminates. To estimate the effective rank-one convex energy
A study of W(+/-)Z production in proton-proton collisions at root s = 7 TeV is presented using data corresponding to an integrated luminosity of 4.6 fb(-1) collected with the ATLAS detector at the Large Hadron Collider in 2011. In total, 317 candidates, with a background expectation of 68 +/- 10 events, are observed in double-leptonic decay final states with electrons, muons and missing transverse
The presence of surfaces influences the fibril formation kinetics of peptides and proteins. We present a systematic study of the aggregation kinetics of amyloidogenic peptides caused by different surfaces using molecular simulations of model peptides and thioflavin T fluorescence experiments. Increasing the monomer surface attraction affects the nucleation and growth of small oligomers in a nonlin
The global socially engaged Buddhist movement emphasis Buddhism’s engagement with society. It is a socially and politically active form of Buddhism that came into being in the twentieth century. Engaged Buddhism is a non-centralized movement that emerged in response to multiple crises in modern Asia. It has been described as a modern form of Buddhism, influenced by; modern, social, economic, psych
The objective of this paper is to analyse the Constructive Dialogue, an initiative for collaborative and integrated urban governance for a sustainable built environment. The dialogue processes, implemented in six Swedish cities in 2004-2009, involved various actors and many types of initiative. Designed as a meta-analysis based on existing evaluations and supplementary interviews, this study exami
Two methods for volume flow calculation from images of methane leakages to the atmosphere are presented. The images contain calibrated gas concentration x path length pixel information, and are processed with a block matching method and a theoretical velocity field method. Results from known methane flow in two laboratory setups and one unknown real leakage from a gas processing plant are compared
