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Efficacy of the antibacterial envelope to prevent cardiac implantable electronic device infection in a high-risk population

AimsInfection is a serious complication of cardiac implantable electronic device (CIED) therapy. An antibiotic-eluting absorbable envelope has been developed to reduce the infection rate, but studies investigating the efficacy and a reasonable number needed to treat in high-risk populations for infections are limited.Methods and resultsOne hundred and forty-four patients undergoing CIED implantati

Possible Relationship between the HLA-DRA1 Intron Haplotype of Three Single-Nucleotide Polymorphisms in Intron 1 of the HLA-DRA1 Gene and Autoantibodies in Children at Increased Genetic Risk for Autoimmune Type 1 Diabetes

Recently, a haplotype of three single-nucleotide polymorphisms (tri-SNP) in intron 1 of the HLA-DRA1 gene was found to be strongly associated with type 1 diabetes risk in HLA-DR3/3 individuals. The tri-SNP reportedly function as “expression quantitative trait loci,” modulating HLA-DR and -DQ expression. The aim was to investigate HLA-DRA1 tri-SNPs in relation to extended HLA class II haplotypes an

Assessing Theoretical Research Contributions in CCT

The present manuscript assesses the rhetorical claims made by authors in a selected corpus of CCT articles (2005-2019) in three representative journals. Against the widespread mantras of “theoretical contributions”, it offers a humble, pluralist framework for CCT scholars to shape and develop relevant and impactful research contributions.

Efficient methods for Gaussian Markov random fields under sparse linear constraints

Methods for inference and simulation of linearly constrained Gaussian MarkovRandom Fields (GMRF) are computationally prohibitive when the number ofconstraints is large. In some cases, such as for intrinsic GMRFs, they may even beunfeasible. We propose a new class of methods to overcome these challenges in the common case of sparse constraints, where one has a large number of constraints and each o

Liftarens parlör till galaxen : en berättelse om 101 språk som egentligen inte finns

Följ med på en resa från Tolkien, Star Trek, Game of Thrones, Tarzan och Tintin, till dystopiska dialekter hos Burgess och Orwell. Från nunnan Hildegard av Bingen på 1100-talet, över Swift och Rabelais till Pingu och Linus på Linjen.Det här är en bok om 101 påhittade språk: klingonska, valyriska, syldaviska, na vi, lilliputianska, orkiska, för att nämna några. Språk från länder som inte existerar,

On the role of terrestrial ecosystems in a changing Arctic

The global temperature rise is proportional to the cumulative amount of CO2 emissions to the atmosphere. This observation is consistent between climate models and historical observations. It has also given rise to the concept of a carbon budget, which sets a threshold for the amount of CO2 that can be emitted into the atmosphere while still fulfilling political goals such as the Paris Agreement.Te

RNA sequencing-based single sample predictors of molecular subtype and risk of recurrence for clinical assessment of early-stage breast cancer

Multigene assays for molecular subtypes and biomarkers can aid management of early invasive breast cancer. Using RNA-sequencing we aimed to develop single-sample predictor (SSP) models for clinical markers, subtypes, and risk of recurrence (ROR). A cohort of 7743 patients was divided into training and test set. We trained SSPs for subtypes and ROR assigned by nearest-centroid (NC) methods and SSPs

Tourism Resourcification

A conventional claim within tourism research, practice and policy is that tourism is a powerful engine for economic growth across all spatial scales, accounting for slightly more than 10 percent of the global number of jobs and gross domestic product (GDP). What does this tell us? First, that the tourism economy is heavily dependent on mobilising spatial, intangible, material and human resources.

How Reliable Are Gene Expression-Based and Immunohistochemical Biomarkers Assessed on a Core-Needle Biopsy? A Study of Paired Core-Needle Biopsies and Surgical Specimens in Early Breast Cancer

In early breast cancer, a preoperative core-needle biopsy (CNB) is vital to confirm the malignancy of suspected lesions and for assessing the expression of treatment predictive and prognostic biomarkers in the tumor to choose the optimal treatments, emphasizing the importance of obtaining reliable results when biomarker status is assessed on a CNB specimen. This study aims to determine the concord

Take the Elevator to Tomorrow : Mobile Space and Lingering Time in Contemporary Urban Fiction

What if, in the encounter between the subject and the city, it is the buildings, the streets, the rooms that are moving and the human beings who are at a standstill? Inspired by the efforts of literary scholars and human geographers to apply a unified understanding of space and time to the study of the (fictional) city, this article employs an analysis centered on the figure of the elevator to exp