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AIM: Right ventricular (RV) function determines symptom burden and clinical outcomes in pulmonary hypertension (PH). Global wasted work (GWW) quantifies mechanical inefficiencies in RV performance associated with elevated afterload, but is inadequately characterized in precapillary PH. We assessed the association of GWW with echocardiographic indices of RV remodeling, RV-PA coupling and invasive h

We present the first ever dataset of manually segmented and transcribed Ajami manuscripts written in Fulfulde and Hausa. The term Ajami refers to modified Arabic-script orthographies in Africa. Existing handwritten text recognition (HTR) and optical character recognition (OCR) models for Arabic-script languages perform poorly on West African manuscripts due to a lack of these manuscripts represent

Estuaries are complex environments rich in biodiversity, making it challenging to understand the distribution and occurrence of microplastics due to the multiple variables that can influence the movement of these particles. Based on this, this study evaluated the influence of different environmental aspects on the distribution and transport of microplastics in the surface waters of the Tramandaí R

Recent droughts from 2017 to 2020 induced significant stress on woodland canopies across eastern Australia, resulting in widespread tree browning and mortality. However, the trajectory of post-drought recovery remains unclear, with uncertainty about whether canopy conditions are improving or continuing to decline. Identifying the key local environmental and climatic factors influencing drought-ind

The aim of this study was to investigate whether cross-site networking of environmental managers in globally active companies can offer a solution for the efficient internal use of intangible resources. In addition, it examines whether findings from research and practice on interorganisational environmental networks can be transferred to intraorganisational contexts. The study is based on a case s

Knee osteoarthritis (OA) and obesity are closely linked, with obesity being the primary risk factor for OA. This study used the medial meniscus of sows (250 kg, 4–6 years old) as a model for spontaneous OA, comparing them to lighter pigs (110 kg, 7–8 months old). The joints were collected according to the 3Rs principles (Replacement, Reduction and Refinement) and compared using macroscopic and mic

Compound heterozygosity for strong hypomorphic mutations in the PRKN gene is a common cause of autosomal familial Parkinson's disease (PD). We generated an iPSC cell line from the fibroblasts of a PARKIN protein-deficient early-onset PD female patient, carrying genomic deletions of exon 2 and exons 5–7. This line displays characteristic human iPSC morphology and expression of pluripotency-associat

Arid regions in Central Asia face persistent and increasing water scarcity, with groundwater serving as the primary source for drinking water, irrigation, and industry. The effective exploration and management of groundwater resources are critical, but are constrained by limited monitoring infrastructure and complex hydrogeological settings. This study investigates the Akbakay aquifer, a represent

Loess-palaeosol sequences (LPS) are among the most continuous terrestrial archives of Quaternary climate change. Their widespread distribution, high accumulation potential, and sensitivity to environmental variability make them critical for reconstructing past dust fluxes, wind regimes, and regional ecosystem responses. However, the reliability of such reconstructions is fundamentally constrained

Multiple myeloma (MM) is the second most common blood malignancy, with several lines of evidence supporting an inherited genetic component. Here, we sequenced 177 affected individuals from 128 families, and 170 early-onset MM cases diagnosed before 55 years of age. Samples were identified and collected through nationwide efforts in France, Sweden, and Greece. We focused on rare germline protein tr

The aim of this workshopreport is to move beyond existing academicdiscussions on environmental politics in North and EastSyria3, and to respond directly to the region’s urgentenvironmental needs and challenges, and to explorepossible pathways for ecological recovery and justice.We seek to critically examine the political, social, andecological dimensions of environmental governancein post-conflict

In this chapter, I describe how acceptance- and mindfulness-based strategies can be integrated into insomnia treatment. The chapter consists of four main sections. The first section introduces these strategies, examines the scientific/theoretical rationale for their use, provides a review of the empirical evidence, and highlights the importance of personalizing treatment. The second and third sect

Dupljaja loess-palaeosol sequence in southeasternmost sector of the Banat Loess Plateau (Serbia), situated in the southeastern Carpathian (Middle Danube) Basin, is important for understanding the evolution of the Last Glacial climate and southeastern Carpathian as a potential corridor for human migration throughout Europe. The Dupljaja loess-palaeosol sequence in the southeasternmost sector of the

In this study, we investigated overbank sediments of the first terrace of Sava river in Šabac, exposed at a residential building construction site. Sediment characteristics such as grain size, magnetic susceptibility, chemical composition, and loss on ignition (LOI) at 550 °C and 950 °C were determined at 5 cm resolution, accompanied by visual inspection to assess color, pedogenic structure, and o

We investigate how the anchoring effect—a well-established cognitive bias—influences subjective belief distributions. While prior research extensively examines the impact of anchoring and other biases on point estimates, their effect on the underlying distribution and its higher moments remains unexplored. Using two pre-registered online experiments (N = 1467) and two elicitation methods, we find

Despite the centrality of economic theories (including political economic theories) in human geographic research, there is a massive shortage of courses covering this topic in many human geography departments. In this paper, we use the example of a third-semester elective MSc course in political economic theory designed for students in human geography to contribute to this point. The course aims t