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Purpose: Personalized cancer treatment requires predictive biomarkers, including image-based biomarkers. Breast cancer (BC) patients receiving neoadjuvant chemotherapy (NACT) are in a clinically vulnerable situation with the tumor present. This study investigated whether mammographic density (MD), assessed pre-NACT, is predictive of pathological complete response (pCR). Methods: A total of 495 BC

The article challenges the theoretical “sectoral model” of civil society through a historical case study and offers an alternative actor-centered approach inspired by American pragmatism. First, three separate strands of research are identified that each conceptualize civil society as a sector with institutional independence, a single normative logic, and fixed roles. Building on archival material

The pancreas is particularly sensitive to acute cellular stress, but this has been difficult to evaluate using light microscopy. Pancreatic ischaemia associated with deceased organ donation negatively impacts whole-organ and isolated-islet transplantation outcomes. Post-mortem changes have also hampered accurate interpretation of ante-mortem pancreatic pathology. A rigorous histological scoring sy

Aim: The primary aim was to compare the 30-day morbidity and mortality in patients aged ≥80 years undergoing surgery for colorectal cancer with those aged <80 years. The secondary aim was to identify independent outcome predictors. Method: This was a retrospective study of patients undergoing surgery for colorectal cancer between January 2007 and February 2018. Patients were divided into those <80

Objective: Dose optimization and pharmacokinetic evaluation of α-particle emitting radium-223 dichloride (223RaCl2) by planar γ-camera or single photon emission computed tomography (SPECT) imaging are hampered by the low photon abundance and injected activities. In this study, we demonstrate SPECT of 223Ra using phantoms and small animal in vivo models. Methods: Line phantoms and mice bearing 223R

Fire safety provisions in building regulation are about managing risk. In order to appropriately characterize and incorporate risk measures into building regulation, it is helpful to view building regulatory systems (BRS) as complex socio-technical systems (STS), wherein there are interactions between institutions, technology and people, which ideally work together to mitigate risk to a societally

The clinical value of the polygenetic component of blood pressure (BP) is commonly questioned. We evaluated a genetic risk score for BP (BP-GRS858), based on the most recently published genome-wide association studies variants that were significantly associated with either systolic BP or diastolic BP, for prediction of hypertension and cardiovascular end points. The genotyping was performed in 2 u

Time perspective has been recognized as an important psychological dimension with a pervasive and powerful influence on human behavior. To the authors’ knowledge, no studies have focused on the relationship between time perspective and cyberbullying behavior. The first aim of this research is to fill this gap by investigating the relationship between different time perspectives and both cyberbully

Drainage networks delineated from Digital Elevation Models (DEMs), are the basis for the modelling of geomorphological and hydrological processes, biogeochemical cycling, and water resources management. Besides providing effective models of water flows, automatically extracted drainage networks based on topography can diverge from reality to varying degrees. The variability of such disagreement wi

Background: Gallbladder cancer (GBC) has a poor prognosis. The aim was to develop and validate a preoperative risk score for incidental gallbladder cancer (IGBC) in patients scheduled for cholecystectomy. Methods: Data registered in the nationwide Swedish Registry for Gallstone Surgery (GallRiks) was analyzed, including the derivation cohort (n = 28915, 2007–2014) and the validation cohort (n = 78

We report thermometry and new Raman linewidth data using a novel method for time-domain rotational coherent anti-Stokes Raman spectroscopy (RCARS) on single-shot basis. The coherences are generated by two fs pulses and probed by a ns pulse. The resulting signal is detected using a combined spectrograph/streak camera setup with high spectral and temporal resolution. Rotational CARS spectrograms of

Summary: Background: Diabetes mellitus (DM) is a risk factor for peripheral arterial disease (PAD). Indications for open surgery in infrainguinal intermittent claudication (IC) are limited, and reports are lacking regarding outcomes in DM patients. Study aims were to compare short and long-term effects on major adverse cardiovascular events (MACE), acute myocardial infarction (AMI), stroke, major

Background: The coronavirus disease 2019 (COVID-19) pandemic calls for effective and safe treatments. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing COVID-19 actively replicates in the throat, unlike SARS-CoV, and shows high pharyngeal viral shedding even in patients with mild symptoms of the disease. HCoV-229E is one of four coronaviruses causing the common cold. In this stu

Background: Breast cancer-related lymphedema (BCRL) is associated with impaired function and poorer quality of life. BCRL is also considered time-consuming and costly to treat. While compression treatment is considered the most efficient and effective form of treatment for early BCRL, its impact on the lymphatic system highlights its potential in the prevention of lymphedema. Objectives: To identi

Background: Geographic variations in management and outcomes of individuals supported by continuous-flow left ventricular assist devices (CF-LVAD) between the United States (US) and Europe (EU) is largely unknown. Methods: We created a retrospective, multinational registry of 524 patients who received a CF-LVAD (either HVAD or Heartmate II) between January 2008 and April 2017. Follow up spanned fr

Background & Aims: Few patients with primary sclerosing cholangitis (PSC) and inflammatory bowel diseases (IBDs) are exposed to tumor necrosis factor (TNF) antagonists because of the often mild symptoms of IBD. We assessed the effects of anti-TNF agents on liver function in patients with PSC and IBD, and their efficacy in treatment of IBD. Methods: We performed a retrospective analysis of 141