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Smart Public Transport in Rural Areas: Prospects, Challenges and Policy Needs

There is a heavy dependence on cars for people living in rural areas and small towns. The countryside has so far been left out of the transition to carbon-free transport, and public transport shares are low in rural areas. New information and communication technology (ICT) solutions and autonomous vehicles (AVs) have the potential to improve the conditions for public transport in rural areas, as t

Effects of a local auxiliary protein on the two-dimensional affinity of a TCR-peptide MHC interaction

The affinity of T-cell receptors (TCRs) for major histocompatibility complex molecules (MHCs) presenting cognate antigens likely determines whether T cells initiate immune responses, or not. There exist few measurements of two-dimensional (2D) TCR-MHC interactions, and the effect of auxiliary proteins on binding is unexplored. Here, Jurkat T-cells expressing the MHC molecule HLA-DQ8-glia-α1 and th