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Coronary artery disease (CAD) is the commonest cause of death. Here, we report an association analysis in 63,746 CAD cases and 130,681 controls identifying 15 loci reaching genome-wide significance, taking the number of susceptibility loci for CAD to 46, and a further 104 independent variants (r(2) < 0.2) strongly associated with CAD at a 5% false discovery rate (FDR). Together, these variants exp
Heteroclitic monoclonal antibodies are characterized by the ability to bind multiple epitopes with little or no similarity. Such antibodies have been reported earlier, but insight into to the molecular basis of this propensity is limited. Here we report that the KIM185 antibody to human CD18 reacts with the plasma protein C4b-binding protein (C4BP). This was revealed during affinity purification p
Objectives To study regional cerebral blood perfusion with power Doppler ultrasound (PDU) imaging in appropriate-for-gestational age (AGA) fetuses and those with intrauterine growth restriction (IUGR) at different hemodynamic stages of fetal deterioration. Methods Brain blood perfusion was studied with PDU imaging, and the fractional moving blood volume (FMB V) was estimated in 56 growth-restricte
This document presents the 2012 evidence based guidelines of the Swedish Society of Infectious Diseases for the in-hospital management of adult immunocompetent patients with community-acquired pneumonia (CAP). The prognostic score 'CRB-65' is recommended for the initial assessment of all CAP patients, and should be regarded as an aid for decision-making concerning the level of care required, micro
Selecting the appropriate analytical methods for characterizing the assembly and morphology of polymer-based vesicles, or polymersomes are required to reach their full potential in biotechnology. This work presents and compares 17 different techniques for their ability to adequately report size, lamellarity, elastic properties, bilayer surface charge, thickness and polarity of polybutadiene-polyet
Coping with the immune rejection of allotransplants or autologous cells in patients with an active sensitization towards their autoantigens and autoimmunity presently necessitates life-long immune suppressive therapy acting on the immune system as a whole, which makes the patients vulnerable to infections and increases their risk of developing cancer. New technologies to induce antigen selective l
In 2006 a palisade enclosure dated to the late Middle Neolithic was excavated at Bunkeflostrand, Malmö, Sweden. The excavation of pits and wells containing flints, animal bones and pottery revealed a wide range of activities at the site, which is exceptional in comparison with most other palisade enclosures of southern Scandinavia. Palisade enclosures have emerged as places of great significance t
Background: Autoantibodies to cyclic citrullinated peptides (anti-CCP) are present in most patients with rheumatoid arthritis ( RA), and associate with HLA-DRB1 shared epitope (SE) alleles. Objective: To investigate reactivities of anti-CCP to various citrullinated proteins/peptides, which represent potential autoantigens in RA, and to examine the relationship between such antibodies, and their as
In insects, the surface area of the compound eye increases with body size both within and between species with only a slight negative allometry. This increase in surface area permits changes in eye structure that affect the eye's acuity and sensitivity, two features of eye performance that cannot be simultaneously maximized. Hence, as eye size varies within a lineage, so will the compromises betwe
System-on-chips (SOCs) and 3D stacked ICs are often tested for manufacturing defects in a modular fashion, enabling us to record the module test pass probability. We use this pass probability to exploit the abort-on-fail feature of automatic test equipment (ATE) and hence reduce the expected test time in the context of single-site testing. We present a model for calculation of expected test time,
Voorhees et al. (Reports, 5 November 2010, p. 835) determined the structure of elongation factor Tu (EF-Tu) and aminoacyl-transfer RNA bound to the ribosome with a guanosine triphosphate (GTP) analog. However, their identification of histidine-84 of EF-Tu as deprotonating the catalytic water molecule is problematic in relation to their atomic structure; the terminal phosphate of GTP is more likely
Transverse momentum spectra of electrons (p(T)(e)) from semileptonic weak decays of heavy-flavor mesons in the range of 0.3 < p(T)(e) < 9.0 GeV/c have been measured at midrapidity (|y| < 0.35) by the PHENIX experiment at the Relativistic Heavy Ion Collider in p + p and Au + Au collisions at root s(NN) = 200 GeV. In addition, the azimuthal anisotropy parameter v(2) has been measured for 0.3 < p(T)(
The far-infrared absorption spectra have been recorded for hydrogen-bonded complexes of water with methanol and t-butanol embedded in cryogenic neon matrices at 2.8 K. The partial isotopic substitution of individual subunits enabled by a dual inlet deposition procedure provides for the first time unambiguous assignments of the intermolecular high-frequency out-of-plane and low-frequency in-plane d
Popular Abstract in Swedish De flesta större operationer på hjärtat idag kräver att hjärtat under en del av operationen står stilla utan att blod cirkulerar igenom det. För att kunna bibehålla ett blodflöde av syresatt blod genom kroppen kopplas en hjärt-lungmaskin till patienten. Blodet förs via slangar från höger förmak först ner till ett uppsamlingskärl, varifrån blodet pumpas vidare genom en oThe use of cardiotomy suction during open heart surgery with cardiopulmonary bypass (CPB) has a long tradition and often regarded as mandatory. Recently, studies have described potentially negative effects of cardiotomy suction with activation of the complement system, enhanced inflammatory response, hemolysis and coagulopathy. Emboli of various matters has also been studied. Whether they affect t
A two-stage system was investigated for anaerobic digestion (AD) of aerobically pre-treated sisal leaf decortication residue (SLDR) with regard to hydrolytic enzymes and biogas production. The system consisted of a solid-bed bioreactor for hydrolysis connected to methanogenic bioreactor packed with sisal fibre decortication residues (SFDR) as biofilm carriers. Some of the enzymes produced by micro
The long-range order in strongly coupled dipolar systems has been studied using large-scale simulations for systems containing up to 100 000 particles. It is found that the boundary conditions used strongly influence the result. It is found that a periodic system modeled with the minimum image approximation yields an artificial order, whereas the same system described using the Ewald summation tec
