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Neutrophil cannibalism--a back up when the macrophage clearance system is insufficient.

Background: During a lipopolysaccharide-induced lung inflammation, a massive accumulation of neutrophils occurs, which is normally cleared by macrophage phagocytosis following neutrophil apoptosis. However, in cases of extensive apoptosis the normal clearance system may fail, resulting in extensive neutrophil secondary necrosis. The aim of this study was to explore the hypothesis that neutrophils,

Instruments to foster renewable energy investments in Europe

Since capital needs are high when investing in Renewable Energy Technologies (RET), well adapted financial schemes are essential, including well fitted financial support. Supporting the dissemination of RET means supporting people, not technologies. Though, support mechanism have to be adapted to people not to technologies. A recent study for the European Parliament compares support mechanisms for

Comparison of thermal manikins of different body shapes and size

Differences between manikins may be present due to manikin body shapes (male versus female). In order to examine such differences a study was designed. Comparisons were carried out based on: (1) tight versus loose clothing; (2) serial versus parallel calculation models; (3) even versus uneven clothing (insulation) distribution; and (4) the effect of donning clothes. Differences were observed betwe

Routes to Equity Market Integration – the interplay between Politicians, Investors and Managers

Most econometric studies of equity market integration suggest that national markets are increasingly becoming part of a global equity market. As regards the extent of this integration, however, the results are often inconclusive. Further analysis calls for a closer scrutiny of the basic requirements for perfect integration. This paper presents an analysis of market segmentation in terms of existin

Sudden cardiac death risk factors in patients with heart failure treated with carvedilol

Background: Chronic heart failure (CHF) is associated with a high risk of sudden cardiac death (SCID). Most frequently SCID occurs in patients with NYHA class II and III. Aim: To evaluate the influence of prolonged carvedilol therapy on SCID risk in CHF patients. Methods: The study included 86 patients (81 men and 5 women) aged 56.8 +/- 9.19 (35-70) years with CHF in NYHA class II and III receivin

Gene expression and immune response kinetics using electroporation-mediated DNA delivery to muscle

Background Injection of DNA encoding exogenic proteins into muscle tissue combined with electroporation often results in a transient increase of the encoded protein concentration in the muscle and the blood. The reduction is normally due to an immune response against the exogenic protein but other factors may also be involved. How various electroporation parameters affect the concentration kinetic

UDP acts as a growth factor for vascular smooth muscle cells by activation of P2Y(6) receptors.

Mitogenic effects of the extracellular nucleotides ATP and UTP are mediated by P2Y(1), P2Y(2), and P2Y(4) receptors. However, it has not been possible to examine the highly expressed UDP-sensitive P2Y(6) receptor because of the lack of stable, selective agonists. In rat aorta smooth muscle cells (vascular smooth muscle cells; VSMC), UDP and UTP stimulated (3)H-labeled thymidine incorporation with

A palaeomagnetic and Ar-40/Ar-39 study of late precambrian sills in the SW part of the Amazonian craton: Amazonia in the Rodinia reconstruction

A new key palaeomagnetic pole (Plat. = 64.3 degrees S, Plon. = 271.0 degrees E, N = 14, A(95) = 9.2 degrees; Q = 5) is calculated from a primary magnetization isolated in early Neoproterozoic Aguapei basic sills and dykes hosted by 1.3-1.0 Ga sedimentary rocks from the southwestern part of the Amazon craton. The characteristic remanence carried by stable, pseudo-single domain titanomagnetite shows

Angiotensin II-induced vasodilatation in cerebral arteries is mediated by endothelium-derived hyperpolarising factor.

The angiotensin II-induced vasodilatation was evaluated in rat middle cerebral artery, especially regarding endothelium-derived hyperpolarising factor (EDHF), by use of a pressurised arteriograph. The angiotensin II dilatation was partly antagonised by inhibitors of nitric oxide synthase and cyclo-oxygenase. The remaining dilatation was inhibited by the potassium channel blockers, charybdotoxin an

Cytologic features of primary, recurrent, and metastatic dermatofibrosarcoma protuberans

BACKGROUND: Dermatofibrosarcoma protuberans (DFSP) is a low-grade spindle cell neoplasm involving both dermis and subcutis. Its diagnosis may be difficult to render from cytologic smears, as it shares some features with other spindle cell lesions occurring in the skin and soft tissue.METHODS: Fourteen aspiration smears from 12 patients with primary, recurrent, or metastatic DFSP, examined by fine-

Histologic reactions to particulate wear debris in different mesenchymal tissues - Studies on the nonreplaced compartment from revised uni-knees

The interface between bone and artificial-joint implants consists of soft tissue. This tissue varies from fibrocartilage to loose fibrous tissue. Tissues that resemble those can be found in normal joints. Sixteen knees with unicompartmental knee prostheses, revised because of excessive wear of the tibial insert, were studied. Synovium, synovial fluid, cartilage, and bone from the nonreplaced compa

From synergy to symbiosis: new directions in security and privacy?

The objective of this article reflects upon the isomorphic relationship between ideas across disciplines. In this instance we are considering the value of a well established methodology, cross methodology, adopted from macroeconomics and ideas from political science. The cross methodology is used as a means of considering the relationship between data collected for security purposes and individual