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Intrapartum fetal ECG and diabetes

Aim. The objective of this study was to determine the prevalence and types of ST-segment changes of the fetal electrocardiogram (FECG) during labour in term fetuses born to mothers with diabetes mellitus (DM) or gestational diabetes. Methods. This was a retrospective case-control study involving populations from two multi centre trials: the Swedish Randomized Control Trial and the European Union S

Phase I safety, pharmacokinetic, and pharmacodynamic trial of ZD1839, a selective oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with five selected solid tumor types

PURPOSE: To establish the safety and tolerability of ZD1839 (Iressa), a selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, and to explore its pharmacokinetic and pharmacodynamic effects in patients with selected solid tumor types. PATIENTS AND METHODS: This was a phase I dose-escalating trial of oral ZD1839 150 mg/d to a maximum of 1,000 mg/d given once daily for at least

Uncertain biotic and abiotic interactions in benthic communities

We analyze marine benthic communities at different sites in Skagerrak with the purpose of understanding the role of exogenous and endogenous factors in explaining the species' temporal dynamics. The previous finding that the dynamics of these species communities are mainly driven and synchronized by environmental (temperature) forcing was only weakly supported when analyzing single-species dynamic

Sun exposure and melanoma risk at different latitudes: a pooled analysis of 5700 cases and 7216 controls

Background Melanoma risk is related to sun exposure; we have investigated risk variation by tumour site and latitude. Methods We performed a pooled analysis of 15 case-control studies (5700 melanoma cases and 7216 controls), correlating patterns of sun exposure, sunburn and solar keratoses (three studies) with melanoma risk. Pooled odds ratios (pORs) and 95% Bayesian confidence intervals (CIs) wer

Modulation of granulocyte-endothelium interactions by antileukoproteinase: inhibition of anti-type II collagen antibody-induced leukocyte attachment to the synovial endothelium

Antileukoproteinase (ALP) is a physiological inhibitor of granulocytic serine proteases that has been shown to have anti-inflammatory properties in addition to its antiproteolytic activity. On the basis of its potential to block anti-collagen type II (CII) antibody-induced arthritis (CAIA) and to suppress the conformational activation of beta(2)-integrins in leukocytes, the present study was under

Subaxial antero-posterior dislocation of the cervical spine in rheumatoid arthritis

A subaxial (below C2) antero-posterior dislocation of the cervical spine was present in 18% of 407 patients with rheumatoid arthritis. The dislocation was as common at only one level as at two more levels and was more severe if the height of the spinous process was reduced. Most of these same patients also had an atlanto-axial dislocation. At follow-up examinations, the frequency of a subaxial dis

Emissions of greenhouse gases from ponds constructed for nitrogen removal

Methane and carbon dioxide emission from three constructed ponds were monitored during an annual cycle. Water temperature was a good predictor of methane emission in all three ponds. In the most intensively studied pond, nitrate concentration in the bottom water could further explain the amount of methane emitted. When water temperature exceeded 15 °C between 1 and 54 mg, CH4 m−2 h−1 was emitted o

Wave patterns in frequency-entrained oscillator lattices

We study and classify firing waves in two-dimensional oscillator lattices. To do so, we simulate a pulse-coupled oscillator model aimed to resemble a group of pacemaker cells in the heart. The oscillators are assigned random natural frequencies, and we focus on frequency entrained states. Depending on the initial condition, three types of wave landscapes are seen asymptotically. A concentric lands

Perceptions of the concept of health among nurses working in mental health services: A phenomenographic study.

A new understanding of the concept of health is needed to meet the goal of mental health nursing, which besides reducing disease is to strengthen the patient's health. The aim of the present study was to describe perceptions of the concept of health among nurses working in mental health services. Twelve Swedish nurses working in mental health services were interviewed and data were analysed with a

Testing two methods to create comparable scale scores between the Job Content Questionnaire (JCQ) and JCQ-Like questionnaires in the European JACE study

Background: Scale comparative properties of "JCQ-Iike" questionnaires with respect to the JCQ have been little known. Purpose: Assessing validity and reliability of two methods for generating comparable scale scores between the Job Content Questionnaire (JCQ) and JCQ-like questionnaires in sub-populations of the large Job Stress, Absenteeism and Coronary Heart Disease European Cooperative (JACE) s

Effect of mobilization of bone marrow stem cells by granulocyte colony stimulating factor on clinical symptoms, left ventricular perfusion and function in patients with severe chronic ischemic heart disease

Objectives: A phase I safety and efficacy study with granulocyte colony stimulating factor (G-CSF) mobilization of bone marrow stem cells to induce vasculogenesis in patients with severe ischemic heart disease (IHD) was conducted. Design, patients and results: 29 patients with IHD participated in the study. Thirteen patients were treated with G-CSF for 6 days and 16 patients served as controls. G-

Interorganization Theory and International Organization

This article explores the applicability of a conceptual framework derived from interorganization theory and network analysis to the study of international organization. The framework emphasizes the pivotal role of linking-pin organizations and of boundary-role personnel within these organizations in transnational networks. A set of issue-specific and organization-specific factors accounting for va

Dissection of the genetic complexity of arthritis using animal models.

Rheumatoid arthritis (RA) is a chronic inflammatory disease directed towards peripheral joints. As all common diseases it is associated with several genes and a multitude of environmental factors. In addition, in similarity with most other complex diseases, it is defined only on the basis of clinical signs and symptoms, it is therefore more properly classified as a syndrome rather than a distinct

Presumptive horizontal symbiont transmission in the fungus-growing termite Macrotermes natalensis

All colonies of the fungus-growing termite Macrotermes natalensis studied so far are associated with a single genetically variable lineage of Termitomyces symbionts. Such limited genetic variation of symbionts and the absence of sexual fruiting bodies (mushrooms) on M. natalensis mounds would be compatible with clonal vertical transmission, as is known to occur in Macrotermes bellicosus. We invest

Solid-state characteristics and redispersible properties of powders formed by spray-drying and freeze-drying cereal dispersions of varying (1→3,1→4)--glucan content

Cereal powders containing 33, 18 and 4% (w/w) (1→3,1→4)--glucan, prepared from cereal suspensions, had distinct differences in surface morphology as observed by scanning electron microscopy, depending both on the drying process (spray- or freeze-drying) and the dietary fibre level. Freeze-drying produced powders with a ‘flake-like’ matrix, without particle formation and similar matrix morphology i