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The complement system consists of more than 40 proteins that participate in the inflammatory response and in pathogen killing. Complement inhibitors are necessary to avoid the excessive consumption and activation of this system on host cells. Leptospirosis is a worldwide zoonosis caused by spirochetes from the genus Leptospira. Pathogenic leptospires are able to escape from complement activation b
Severely disturbed habitats such as military training grounds, gravel pits and sand pits contribute to the species diversity of the agricultural landscape in Europe. They host a number of red-listed species not found elsewhere, illustrating that many plant species are threatened by extinction due to too little soil disturbance. Implementing a suitable disturbance regime is therefore crucial to ens
This article analyses the enabling and restraining conditions of local peace organisations in Israel and Palestine. It utilises the analytical notion of peace gaps to accentuate the interplay between local and elite levels. It also highlights the discrepancies when it comes to expectations of peace, the ability to communicate peace discourses, and the power to influence and build wider domestic pe
Previous studies of mid-Ordovician limestone in Sweden have shown that over a stratigraphic interval representing a few million years there is a two orders-of-magnitude enrichment in fossil L-chondritic meteorites (empty set = 1-21 cm) and sediment-dispersed extraterrestrial chromite (EC) grains (>63 mu m). This has been interpreted as a dramatic increase in the flux of L-chondritic matter to Eart
The ALICE measurement of K_{S}^{0} and Λ production at midrapidity in Pb-Pb collisions at sqrt[s_{NN}]=2.76 TeV is presented. The transverse momentum (p_{T}) spectra are shown for several collision centrality intervals and in the p_{T} range from 0.4 GeV/c (0.6 GeV/c for Λ) to 12 GeV/c. The p_{T} dependence of the Λ/K_{S}^{0} ratios exhibits maxima in the vicinity of 3 GeV/c, and the positions of
The current state-of-the-art presents a multiplicity of evacuation models for simulating emergency scenarios. Each model involves different methodological solutions to represent the same process and each one has its strengths and limitations. In addition, they have their own specific features and often practitioners do not have a thorough understanding of the variables that could be input into the
Dynamic descriptions of static spatial situations, such as the road goes through the forest have attracted a lot of attention across different semantic theories. Analyses in terms of fictive motion and subjective motion have proposed that such expressions are strongly motivated by universal cognitive and conceptual factors. I present theoretical arguments for the conflation of several different mo
We consider the problem of approximating functions that arise in wave-equation imaging by sums of wave packets. Our objective is to find sparse decompositions of image functions, over a finite range of scales. We also address the naturally connected task of numerically approximating the wavefront set. We present an approximation where we use the dyadic parabolic decomposition, but the approach is
"Trabecular Metal Cone" (TM Cone) (Zimmer, Inc, Warsaw, Ind) for reconstruction of bone loss in the proximal tibia during revision total knee arthroplasty is now optional. Forty patients were randomized to receive revision total knee arthroplasty with or without TM Cone (No TM Cone). The Anderson Orthopaedic Research Institute bone loss classification and NexGen revision system were used. Radioste
We have developed a coculture system that establishes DLK+ fetal hepatic progenitors as the authentic supportive cells for expansion of hematopoietic stem (HSCs) and progenitor cells. In 1-week cultures supplemented with serum and supportive cytokines, both cocultured DLK+ fetal hepatic progenitors and their conditioned medium supported rapid expansion of hematopoietic progenitors and a small incr
Non-motor symptoms (NMS) of Parkinson's disease (PD) affect virtually every patient, yet they are under-recognized and under-treated. The NMS Questionnaire (NMSQuest) is a validated 30-item self-assessment instrument useful for NMS screening in clinic.
The statistical properties near phase singularities in a complex wave field are here studied by means of the conditional distributions of the real and imaginary Gaussian components, given a common zero crossing point. The exact distribution is expressed as a Slepian model, where a regression term provides the main structure, with parameters given by the gradients of the Gaussian components at the
Biolubricants derived from vegetable oils are environmentally compatible products due to their low toxicity and good biodegradability. Synthetic esters based on polyols and fatty acids possess suitable properties for lubricant applications, even at extreme temperatures. In this work, synthesis of esters from trimethylolpropane (TMP) and carboxylic acids from C5 to C18 has been studied and compared
We evaluated the performance of the Disease State Index (DSI) method when predicting progression to Alzheimer's disease (AD) in patients with subjective cognitive impairment (SCI), amnestic or non-amnestic mild cognitive impairment (aMCI, naMCI). The DSI model measures patients' similarity to diagnosed cases based on available data, such as cognitive tests, the APOE genotype, CSF biomarkers and MR
The present study investigates whether two types of word combinations (free combinations and collocations) differ in terms of processing by testing Howarth's Continuum Model based on word combination typologies from a phraseological tradition. A visual semantic judgment task was administered to advanced Swedish learners of English (n = 27) and native English-speaking controls (n = 38). Reaction ti
Background: The increasing concentration of populations into large conurbations in recent decades has not been matched by international health assessments, which remain largely focused at the country level. We aimed to demonstrate the use of routine survey data to compare the health of large metropolitan centres across Europe and determine the extent to which differences are due to socio-economic
Application of mycorrhizal inoculum could be one way to increase the yield of rice plants, and reduce the application of fertilizer. We therefore studied arbuscular mycorrhizal fungi (AMF) in the roots of wetland rice (Oryza sativa L.) collected at the seedling, tillering, heading and ripening stages in four paddy wetlands that had been under a high-input and intensively irrigated rice cultivation
G protein-coupled estrogen receptor (GPER), or GPR30, is a membrane receptor reported to mediate non-genomic estrogen responses. Tamoxifen is a partial agonist at GPER in vitro. Here, we investigated if GPER expression is prognostic in primary breast cancer, if the receptor is treatment-predictive for adjuvant tamoxifen, and if receptor subcellular localization has any impact on the prognostic val
Aims/hypothesis Latent autoimmune diabetes in adults (LADA) is phenotypically a hybrid of type 1 and type 2 diabetes. Genetically LADA is poorly characterised but does share genetic predisposition with type 1 diabetes. We aimed to improve the genetic characterisation of LADA and hypothesised that type 2 diabetes-associated gene variants also predispose to LADA, and that the associations would be s
A fundamental question in ecology is whether microorganisms follow the same patterns as multicellular organisms when it comes to population structure and levels of genetic diversity. Enormous population sizes, predominately asexual reproduction and presumably high dispersal because of small body size could have profound implications on their genetic diversity and population structure. Here, we hav
