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AimsAtrial septal defects (ASDs) lead to volume-loaded right ventricles (RVs). ASD closure does not always alleviate symptoms or improve exercise capacity, which is possibly explained by impaired left ventricular (LV) haemodynamics. This study evaluated the effect of ASD closure in children using non-invasive LV pressure–volume (PV) loops derived from cardiac magnetic resonance (CMR) imaging and b
Youth gun violence has surged in Sweden recently. Quantitative studies have described the prevalence and geographical locations of gun violence, but little research has examined how perpetrators and victims themselves experience and make sense of guns. This article draws on ethnographic interviews with young men who have firsthand experience of gun violence in a criminal context. Drawing on narrat
I många av Svenska kyrkans församlingar firas mässa en eller flera gånger i veckan. Nattvarden är i högsta grad både aktuell och angelägen - och den engagerar. Med anledning av en ny kyrkohandbok 2017 och ett biskopsbrev om nattvarden 2020 har såväl gamla som nya frågor väckts, och diskussionen om nattvarden har intensifierats. Inte minst har förhållandet mellan teologin i de normativa dokumenten
Kapitlet diskuterar sex lutherska teologers syn på digitalt förmedlad nattvard.
Mycobacterium tuberculosis is dependent on cysteine biosynthesis, and reduced sulfur compounds such as mycothiol synthesized from cysteine serve in first-line defense mechanisms against oxidative stress imposed by macrophages. Two biosynthetic routes to L-cysteine, each with its own specific cysteine synthase (CysK1 and CysM), have been described in M. tuberculosis, but the function of a third put
The transpeptidase LtdMt2 catalyzes the formation of the (3-3) cross-links characteristic of the peptidoglycan layer in the Mycobacterium tuberculosis cell wall. Bioinformatics analysis suggests that the extramembrane part of the enzyme consists of three domains: two smaller domains (denoted as A and B domains) and a transpeptidase domain (the C domain) at the C-terminus. The crystal structures of
Effective treatment of tuberculosis is frequently hindered by the emerging antimicrobial resistance of Mycobacterium tuberculosis. The present study evaluates monocyclic β-lactam compounds targeting the mycobacterial cell wall remodeling. Novel N-thio-β-lactams were designed, synthesized, and characterized on the L,D-transpeptidase-2, a validated target in M. tuberculosis. The candidates were eval
RipA plays a vital role during cell division of Mycobacterium tuberculosis by degrading the cell wall peptidoglycan at the septum, allowing daughter cell separation. The peptidoglycan degrading activity relies on the NlpC/P60 domain, and as it is potentially harmful when deregulated, spatial and temporal control is necessary in this process. The N-terminal domain of RipA has been proposed to play
β-lactam antibiotics represent a novel direction in the chemotherapy of tuberculosis that brings the peptidoglycan layer of the complex mycobacterial cell wall in focus as a therapeutic target. Peptidoglycan stability in Mycobacterium tuberculosis, especially during infection, relies on the nonconventional peptide cross-links formed by l,d-transpeptidases. These enzymes are known to be inhibited b
Mental fatigue has attracted much attention from researchers as it plays a key role in performance efficiency and safety situations. Functional connectivity analysis using graph theory is an effective method for revealing changes in cognition resources influenced by mental fatigue. Previous studies have revealed that functional networks are dynamically reorganized. Therefore, it is critical to exp
The present invention relates to a method of isolating a desired nucleic acid from a biological solution, which method comprises to selectively precipitate the desired nucleic acid by adding a polycationic precipitating agent to the solution and allowing it to form a complex with said nucleic acid, wherein the precipitating agent is a highly charged linear polymer that comprises quaternary amino g
A separation agent composed of a water unsoluble solid substance with a covalently bound lectin. Said solid substance is structurally composed of a water unsoluble silica or silicate material as basic material and, via a linkage to silicon atoms in the silica or silicate material, a covalently bound lectin.
A chromatographic separation agent composed of a water unsoluble solid substance showing dihydroxybo ryl groups. Said solid substance is structurally composed of a water unsoluble silica or silicate material as basic structure and, via a linkage to silicon atoms in the silica or silicate material, covalently bound dihydrox yboryl groups in acid, salt or complex form.
An agent for chromatographic separation of mixtures of molecules consists of fibres of inorganic or organic material at least the inner core of each fibre being solid and non-porous.
Review of Marketing Death: Culture and the Making of a Life Insurance Market in China by Cheris Shun-ching Chan (Oxford, UK: Oxford University Press)
Bidrag till specialnummer om praktisk teologi
Background:Prenatal alcohol exposure represents a substantial public health concern as it may lead to detrimental outcomes, including pregnancy complications and fetal alcohol spectrum disorder. Although UK national guidance recommends abstaining from alcohol if pregnant or planning a pregnancy, evidence suggests that confusion remains on this topic among members of the public, and little is known
