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Context:Patients with treated adrenal insufficiency (AI) have increased morbidity and mortality rate. Our goal was to improve outcome by developing a once-daily (OD) oral hydrocortisone dual-release tablet with a more physiological exposure-time cortisol profile.Objective:The aim was to compare pharmacokinetics and metabolic outcome between OD and the same daily dose of thrice-daily (TID) dose of
CONTEXT: We previously found telomere repeat amplification protocol (TRAP) in situ helpful in the diagnosis of malignancy in effusions, whereas varying sensitivities and specificities for malignancy were reported by investigators using extract-based TRAP. OBJECTIVE: To compare the 2 methods and to elucidate the discrepancies between them. DESIGN: Twenty-three effusions were analyzed. Telomerase ac
PurposeThe purpose of this study is to assess the effect of three key inter-firm orientations often regarded as central and challenging capabilities within the marketing literature namely (i) market orientation, (ii) entrepreneurial orientation and (iii) brand orientation and their effects on the business performance of a focal international SME.Methodology/approachThe study is based upon a sample
In this study, we evaluated 10 months data (September 2009 to June 2010) of atmospheric aerosol particle number size distribution at three atmospheric observation stations along the Baltic Sea coast: Vavihill (upwind, Sweden), Uto (upwind, Finland), and Preila (downwind, Lithuania). Differences in aerosol particle number size distributions between the upwind and downwind stations during situations
Abstract in UndeterminedThe PYTHIA program is a standard tool for the generation of high-energy collisions, comprising a coherent set of physics models for the evolution from a few-body hard process to a complex multihadronic final state. It contains a library of hard processes and models for initial-and final-state parton showers, multiple parton-parton interactions, beam remnants, string fragmen
Alzheimer’s disease (AD) is clinically characterised by an insidious onset with progressive symptoms of memory impairment, dysphasia, dyspraxia, dygnosia and visuospatial difficulties. Degeneration of neurons in specific regions of the brain, formation of senile plaques and neurofibrillary changes are some of the neuropathological features of the disease. As a result of the degenerating process a
Aims: The aim was to establish a baseline prevalence of skin conditions of public health importance in the general population and taking the validity of the questions into account. Our model is intended for future surveillance of skin conditions. Methods: The suggested questions have for the first time been used in Swedish population surveys. A random sample was taken from the general population a
There has in recent years been great concern about possible cardiac side effects of thiazolidinediones ( TZDs). We present a case-report of a 60 year-old male who developed significant mitral regurgitation during six months treatment with pioglitazone in parallel with laboratory indications of fluid retention. Echocardiography six months after discontinuation of medication showed regression of mit
The objective of the present study was to validate the presence and explore the characteristics of mitochondrial permeability transition (mPT) in isolated mitochondria from human heart tissue in order to investigate if previous findings in animal models of cardiac disorders are translatable to human disease. Mitochondria were rapidly isolated from fresh atrial tissue samples obtained from 14 patie
Article as part of a special issue of Revue du MAUSS on the definition of corruption ed. by J. Soldani. Using anti-corruption to define the concept of corruption, but also asking what would a corruption-free or UNcorrupt society look like?
In this paper we present surface electromyographic (EMG) data collected from 16 channels on five unimpaired subjects and one transradial amputee performing 12 individual finger movements and a rest class. EMG were processed using a traditional Time Domain feature-set and classifiers: a Linear Discriminant Analysis (LDA) a k-Nearest Neighbors (k-NN) and Support Vector Machine (SVM). Using continuou
A new experimental setup for quantitative hydrogen isotopic-ratio microscopy in thin samples (up to 12 mu m) is under development at the Lund Ion Beam Analysis Facility. This technique is derived from the proton-proton scattering technique and has been proven to have the same beneficial features, namely a detection limit below 1 wt-ppm and a depth resolution better than 1 mu m. The method gives ab
Using a combination of experimental and theoretical techniques, we show that a thin RhO2 surface oxide film forms prior to the bulk Rh2O3 corundum oxide on all close-packed single crystal Rh surfaces. Based on previous reports, we argue that the RhO2 surface oxide also forms on vicinal Rh surfaces as well as on Rh nanoparticles. The detailed structure of this film was previously determined using U
Broadband circuit models for electric machines are effective means to understand, predict, and control the phenomenon of conducted Electromagnetic Interference (EMI) from immunity/susceptibility perspective. These models should cover the capacitive and inductive coupling behavior of the component along the frequency band of interest. The circuit models when used under generic SPICE simulation soft
Nitric oxide (NO) was described to inhibit the proliferation of neural stem cells. Some evidence suggests that NO, under certain conditions, can also promote cell proliferation, although the mechanisms responsible for a potential proliferative effect of NO in neural stem cells have remained unaddressed. In this work, we investigated and characterized the proliferative effect of NO in cell cultures
Behavioural variant frontotemporal dementia (bvFTD) is associated with changes in dorsal striatal parts of the basal ganglia (caudate nucleus and putamen), related to dysfunction in the cortico-striato-thalamic circuits which help mediate executive and motor functions. We aimed to determine whether the size and shape of striatal structures correlated with diagnosis of bvFTD, and measures of clinic
On 14 November 2012 the new EU-directive 2012/27/EU was published in the Official Journal of the European Union. In the directive there is a requirement, among others, for individual consumption meters for heat and hot water to be installed by 31 December 2016 in multi-apartment buildings. Individual consumption meters had earlier been found to create a saving behavior due to the tenants being cha
