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The Plasminogen Activation System in Human Endometrium and Endometrial Cancer; Function, Tissue Localization and Prognostic Importance

Popular Abstract in Swedish I avhandlingen studeras plasminogenaktiverings-systemets (PA-systemets) komponenter i livmoderslemhinnan. PA-systemet reglerar omvandlingen av plasminogen till plasmin. Plasminogen är ett inaktivt enzym som finns överallt i kroppsvätskor samt i kroppens olika organ. Aktiveringen katalyseras av aktivatorer, antingen urokinase plasminogen activator (uPA) eller tissue plasThe release of urokinase plasminogen activator (uPA) from endometrial stromal cells decreased after progesterone stimulation, due to upregulation of PA inhibitor 1 (PAI-1) and uPA receptor (uPAR). Subsequently, the uPA:PAI-1 complex was internalized and degraded via uPAR. Predecidual cells in the late secretory phase expressed PAI-1 and uPAR, supporting a specific role for predecidual cells in the

Analysis of Fire Scenarios in Order to Ascertain an Acceptable Safety Level in Multi-Functional Buildings

The construction of multifunctional buildings has increased over the last years as well as the threat level considering antagonistic events. This presents challenges for the fire safety in these types of buildings since the protection objectives needs to be more focused on the functions the buildings are providing. Further the antagonistic exposures might present more challenging fire scenarios. A

Cystatin C functions in vitro and in vivo. Studies on target enzyme inhibition by cystatin C variants and cystatin C deficient mice.

Popular Abstract in Swedish Studier av cystatin C's funktion in vitro och in vivo.Cystatin C variants with Arg8, Leu9 and/or Val10 replaced by Gly residues were produced by site-directed mutagenesis and E. coli expression. Their interactions with the target proteases, cathepsin B, L, H and S, were studied in vitro in order to provide basic structure-function information of use in the design of specific inhibitors for therapeutic use. Val10 was shown to be the most contributing

Biofuels for Transport in Australia

In Australia, policy at the National and State levels induces and blocks the development of biofuels. There is no strong, integrated and consistent policy framework. The market for biofuels lacks momentum and confidence of investors is weak. Current capacity is not utilised. Expansion is not expected before 2015.

Optimal stochastic discrete time–frequency analysis in the ambiguity and time-lag domain

In stochastic time-frequency analysis, the covariance function is often estimated from only one observed realization with the use of a kernel function. For processes in continuous time, this can equivalently be done in the ambiguity domain, with the advantage that the mean square error optimal ambiguity kernel can be computed. For processes in discrete time, several ambiguity domain definitions ha

Reframing the Multilevel Triple Helix in a Regional Innovation System: A case of systemic foresight and regimes in renewal of Skane’s food industry

Most organizational findings on Triple Helix modes of interaction have originated in studies of high-tech sectors and emergent industries, whereas low-tech sectors and mature industries to a less extent have been explored in the Triple Helix literature. A foresight initiative aiming at an enhanced renewal of the mature food industry in the region of Skane, was conducted 2006-2007. Findings from th

Biosynthesis of Dermatan Sulphate. Enzymatic mechanism and role of cytokines

Popular Abstract in Swedish Dermatansulfat liksom kondroitinsulfat är ogrenade kolhydratkedjor som består av aminosockret N-acetylgalaktosamin samt uronsyrorna (sockersyrorna), glukuronsyra eller iduronsyra i repeterande enheter om par två och två. Dessa kedjor, som dessutom är bundna med en esterbindning till aminosyran serin på en proteinstam, kan bestå av nästan ett par hundra modifierade sockeDermatan sulphate is a prominent feature of several different proteoglycans and occurs in almost every tissue of the body. It is an unbranched polymer containing the repeating disaccharide unit of N-acetylgalactosamine and D-glucuronic acid or L-iduronic acid. The polymer can be highly sulphated resulting in an unusual and largely unknown diversity in the chain. The unique step in dermatan sulphat

The Best of All PossibleWorlds: Where Interrogative Games Meet Research Agendas

Erik J. Olsson and David Westlund have recently argued that the standard belief revision representation of an epistemic state is defective. In order to adequately model an epistemic state one needs, in addition to a belief set (or corpus, or theory, i.e. a set closed under deduction) K and (say) an entrenchment relation E, a research agenda A, i.e. a set of questions satisfying certain corpus-rela

Politik i globaliseringens tid

Ordet globalisering har blivit vår tids slagord, som försöker fånga olika förändringsprocesser. På de politiska arenorna är globalisering numera ett centralt begrepp, som utmanar invanda föreställningar och suddar ut traditionella gränslinjer mellan nationell och internationell politik, mellan utrikes- och inrikespolitik och mellan säkerhetspolitik, ekonomisk politik och välfärdspolitik. Den här b

Studies on chondroadherin-an extracellular matrix leucine-rich repeat protein

Popular Abstract in Swedish Populärvetenskaplig sammanfattning: (Popularized summary in swedish) I den här avhandlingen har vi studerat bindväven i brosk. Bindväv är ett samlingsnamn för de stödjevävnader som ger form och struktur åt brosk, ben, senor, hud etc. Bindväven skyddar även inre organ från yttre påverkan. Det är bindväven som ger brosket dess speciella egenskaper och som gör att brosketThis thesis describes chondroadherin, one of the leucine-rich repeat proteins in the extracellular matrix (ECM) of cartilage. Chondroadherin defines a subgroup of its own by not having an N-terminal extension, having a different cysteine pattern and by being devoid of carbohydrate substitutions. Here we show that chondroadherin also have a different exon-intron organization and chromosomal localiz

Försvararens roll. Ideologier och gällande rätt.

Popular Abstract in Swedish Försvarsadvokater ställs i sin praktik inför svårlösta dilemman, som har med advokat-klientförhållandet att göra. Frågan om advokaten exempelvis skall eller bör acceptera ett kontroversiellt uppdrag eller om advokaten skall eller bör följa klientens instruktioner, så länge de inte direkt strider mot lag, är sådana dilemman. Problemen har ingen riktig lösning i lag ellerDefence lawyers, in their practise, from time to time have to resolve various difficult dilemmas in connection with the client relationship, such as accepting repugnant cases or acting on questionable instructions from the client: dilemmas, which involve “hard questions” of guilt and innocence, truth and perjury. Many of these ethi-cal problems have never been subjected to interpretation in Swedis