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Underlying type 1 diabetes is a genetic aetiology dominated by the influence of specific HLA haplotypes involving primarily the class II DR-DQ region. In genetically predisposed children with the DR4-DQ8 haplotype, exogenous factors, yet to be identified, are thought to trigger an autoimmune reaction against insulin, signalled by insulin autoantibodies as the first autoantibody to appear. In child

Purpose: Nationwide data have been lacking on drug abuse (DA)-associated mortality. We do not know the degree to which this excess mortality results from the characteristics of drug-abusing individuals or from the effects of DA itself. Method: DA was assessed from medical, criminal, and prescribed drug registries. Relative pairs discordant for DA were obtained from the Multi-Generation and Twin Re

Higher levels of circulating adiponectin have been related to lower risk of colorectal cancer in several prospective cohort studies, but it remains unclear whether this association may be causal. We aimed to improve causal inference in a Mendelian Randomization meta-analysis using nested case–control studies of the European Prospective Investigation into Cancer and Nutrition (EPIC, 623 cases, 623

The annual total economic costs of workplace-related fatalities, illness and injury in Australia are estimated to exceed $57 billion dollars. Because of these societal costs, much policy attention is given to the reduction in the number and severity of workplace accidents, and in attempting to isolate critical factors impacting on these. Using a unique data set of monthly claims observations in Au

In the food industry, severe fouling of equipment surfaces is common and frequent cleaning is necessary. The aim of this work was to contribute to an understanding of the cleaning process. The adsorption of β-lactoglobulin (β-LG) onto stainless steel surfaces and its removal by detergent were followed at 24 and 82C using in situ ellipsometry. Soil removal using different concentrations of sodium h

In this paper, a compact pattern reconfigurable dual-antenna array is designed at 2.65 GHz for MIMO terminal applications, such as laptops. Each antenna is composed of two layers, i.e., the monopole layer and the PIFA layer. By switching the PIN diodes on each layer, its radiation patterns can be varied between conical and boresight patterns. Two such identical antennas are placed side by side on

Free-machining brass containing 2–3% of lead is a preferred industrial material as it shows excellent machinability where low cutting forces, short chips and reduced tool wear are attained. However this addition of lead, a highly toxic and hazardous material, leads to health and environmental issues. Alternative lead-free brasses are known for poor chip control and accelerated tool wear. The curre

Abstract: This review examines the current status of knowledge of sepsis and pneumonia in the elderly population and how the dynamics of the pulmonary challenge affects outcome and consequences. Led by an unprecedented shift in demographics, where a larger proportion of the population will reach an older age, clinical and experimental research shows that aging is associated with certain pulmonary This review examines the current status of knowledge of sepsis and pneumonia in the elderly population and how the dynamics of the pulmonary challenge affects outcome and consequences. Led by an unprecedented shift in demographics, where a larger proportion of the population will reach an older age, clinical and experimental research shows that aging is associated with certain pulmonary changes, b

TheEl Niño SouthernOscillation(ENSO) isEarth's dominant source of interannual climate variability, but its response to globalwarming remainshighly uncertain1.To improve ourunder standing of ENSO's sensitivity to external climate forcing, it is paramount to determine its past behaviour by using palaeoclimate data and model simulations. Palaeoclimate records show that ENSO has varied considerably si

Most fermentative microorganisms grow well-under anaerobic conditions managing a balanced redox and appropriate energy metabolism, but a few species do exist in which cells have to cope with inadequate energy recovery or capture and/or redox balancing. Two cases of these species, i.e., the metabolically engineered Saccharomyces cerevisiae enabling it to ferment xylose and Lactobacillus reuteri fer

AbstractAim: Although imaging of In vitro labeled leukocytes is commonly used for diagnosing inflammation and infection, data concerning the use of this technique to monitor neutrophil trafficking are scarce. Here we investigated thepotential of 111In-in vitro labeled leukocytes (InWBC) to monitor neutrophil trafficking in an animal model of pulmonary inflammation.Methods: F344 rats were divided i

Communities all over the world are using traditional technologies to extract drinkingwater, irrigate their lands and feed their livestock. But these often sustainable and ancient ways to make use of groundwater are in rapid decline worldwide. A research project started in 1999 to study the rehabilitation of 1500-year old water tunnels called "qanats"in Syria. To Cooperate or not to Cooperate...? d

Eugenics and race played significant roles in Ukrainian interwar nationalism, yet remain largely unstudied. The Ukrainian nationalists’ understanding of the racial makeup of their imagined community was contradictory as they struggled to reconcile their desire for racial “purity” with the realities of significant variations between the populations inhabiting the enormous territories which they sou