Sökresultat

Although gain of 1q occurs in 25% of Burkitt lymphomas (BLs) and 10% of pediatric high hyperdiploid acute lymphoblastic leukemias (ALLs), little is known about the origin, molecular genetic characteristics and functional outcome of dup(1q) in these disorders. Ten dup(1q)-positive BLs/ALLs were investigated by tiling resolution (32k) array CGH analysis, which revealed that the proximal breakpoints

This paper presents a new simple distinguishing attack that can be applied on stream ciphers constructed from filter generators or similar structures. We demonstrate the effectiveness by describing key recovery attacks on the stream cipher LILI-128. One attack on LILI-128 requires 2⁴⁷ bits of keystream and a computational complexity of roughly 2⁵³. This is a significant impro

Most previous studies of leukotriene B-4 (LTB4) pharmacology using primary leukocyte cultures and myeloid cell lines do not differentiate between leukotriene BLT1 and BLT1 receptor activation because both receptors are often expressed by these cells. Here we show that in HeLa cells expressing BLT1 but not BLT2 receptors, BLT1 receptor activation resulted in IP3 mediated calcium release from intrac

An academic 12-lead electrocardiogram (ECG) core laboratory aims to provide the highest possible quality ECG recording, measurement, and storage to aid clinicians in research into important cardiovascular outcomes and to maximize the credibility of scientific results based solely, or in part, on ECG data. This position paper presents a guide for the structure and function of an academic ECG core l

Tumor hypoxia is associated with cancer invasiveness, metastasis and treatment failure. Recent data suggest that the major target for endocrine treatment in breast cancer, ER alpha, is downregulated during hypoxia, but the mechanism behind this remains unknown. MAPK signaling as well as ER alpha regulation has earlier been independently linked to hypoxia and we now demonstrate HIF-1 alpha and ERK1

We present palaeomagnetic inclinations from Late Cretaceous-Early Tertiary deep-water carbonates obtained during ODP Leg 192 drilling at the Ontong Java Plateau (OJP) for the following periods: magnetochrons C33n (73.6-79.1 Ma), C32 (71.1-73.6 Ma), C27r-C31n (61.3-68.7 Ma) and C25-C26 (55.9-60.9 Ma). Compaction-induced inclination shallowing is considered to be negligible for the OJP sediments exa

Deoxyuridine 5′-triphosphate nucleotidohydrolase (dUTPase, EC 3.6.1.23) catalyzes the hydrolysis of dUTP to dUMP and pyrophosphate, and plays important roles in nucleotide metabolism and DNA replication. The dUTPase gene of the retrovirus equine infectious anemia virus (EIAV) was cloned and overexpressed in Escherichia coli using the T7 RNA polymerase expression system. The recombinant vector (pET

Background: The aim of this study was to determine whether relative qualitative and quantitative differences in protein expression could be related to smoke exposure or smoke-induced airway inflammation. We therefore explored and characterized the protein components found in bronchoalveolar lavage (BAL) fluid sampled from either lifelong smokers or never-smokers. Methods: BAL fluid samples obtaine

Abstract Food is frequently packed in a controlled environment of gas, in order to extend shelf life. It is of great importance to be able to monitor the status of the packed food to ensure quality. We demonstrate a technique to monitor the gas inside packages non-intrusively by using a laser spectroscopicmethod in scattering solid materials. The technique named GASMAS (GAs in Scattering Media Abs

The early Russian researchers working in central Siberia seem to have preferred scenarios in which glaciations, in accordance with the classical glaciological concept, originated in the mountains. However, during the last 30 years or so the interest in the glacial history of the region has concentrated on ice sheets spreading from the Kara Sea shelf. There, they could have originated from ice caps

Background/Aim: The aim was to identify subjects with incipient Alzheimer's disease (AD) among patients with mild cognitive impairment (MCI) using brief cognitive tests. Methods: A total of 147 MCI patients were followed for 4-6 years and the incidence of AD was 11.6%/year. At baseline, the cube copying test, clock drawing test, MMSE and measurements of regional cerebral blood flow (rCBF) and cere

It has recently been proposed that X-rays can be switched on sub-picosecond time-scales by using laser-generated coherent optical phonons: The so called phonon Bragg switch. We present here detailed simulations of the efficiency of such a switch by solving the time-dependent generalized Takagi-Taupin equations utilizing a perturbative approach. We explore the switching efficiency in diffraction fr

The formation of segmental grooves during mid embryogenesis in the Drosophila epidermis depends on the specification of a single row of groove cells posteriorly adjacent to cells that express the Hedgehog signal. However, the mechanism of groove formation and the role of the parasegmental organizer, which consists of adjacent rows of hedgehog- and wingless-expressing cells, are not well understood

Semiconductor heterostructures and their implementation into electronic and photonic devices have had tremendous impact on science and technology. In the development of quantum nanoelectronics, one-dimensional (1D) heterostructure devices are receiving a lot of interest. We report here functional 1D resonant tunneling diodes obtained via bottom-up assembly of designed segments of different semicon

One first generation assay (manufactured by Ortho, test I) and 3 second generation anti-HCV ELISAs (manufactured by Ortho, Abbott, and UBI, tests II-IV) were compared. Sera from 4 different sources were used: (1) intravenous drug-users (IVDUs, n = 50), (2) blood donors (n = 1055), (3) all clinical samples from one day of routine anti-HCV testing (n = 89), (4) hemodialysis patients previously found