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How something can be said about telling more than we can know: On choice blindness and introspection

The legacy of Nisbett and Wilson's classic article, Telling More Than We Can Know: Verbal Reports on Mental Processes (1977), is mixed. It is perhaps the most cited article in the recent history of consciousness studies, yet no empirical research program currently exists that continues the work presented in the article. To remedy this, we have introduced an experimental paradigm we call choice bli

Vitamin D is related to blood pressure and other cardiovascular risk factors in middle-aged men

A previous study has shown that serum levels of the active vitamin D metabolite 1,25-(OH)2-vitamin D were inversely related to blood pressure levels while the prohormone 25-OH-vitamin D was found to be related to insulin metabolism. Also other clinical and experimental data support the view that vitamin D metabolism is involved in blood pressure regulation and other metabolic processes. The presen

Influence of genetic polymorphisms of biotransformation enzymes on gene mutations, strand breaks of deoxyribonucleic acid, and micronuclei in mononuclear blood cells and urinary 8-hydroxydeoxyguanosine in potroom workers exposed to polyaromatic hydrocarbons

OBJECTIVES: Airborne exposure to polycyclic aromatic hydrocarbons (PAH) in the potroom of an aluminum reduction plant was studied in relation to genotoxic or mutagenic effects, and the possibility of host genotypes of different metabolizing enzymes modifying associations between PAH exposure and genotoxic or mutagenic response was assessed. SUBJECTS AND METHODS: Ninety-eight male potroom workers a

Follow-up of acute pyelonephritis in children by Tc-99m DMSA scintigraphy - Quantitative and qualitative assessment

Purpose: The author's goal was to create a system to identify children at risk for development of progressive renal damage, Methods: Thirty-four children were examined with Tc-99m DMSA scintigraphy in the acute stage of an initial episode of pyelonephritis, after 6 months, and again after 1 year, The scintigraphic findings were correlated with clinical and laboratory data, Results: All children ha

More efficient mobilisation of peripheral blood stem cells with HiDAC plus AMSA plus G-CSF than with mini-ICE plus G-CSF in patients with AML

We have compared the efficacy of two PBSC mobilisation regimens, mini-ICE + filgrastim (second consolidation) and HiDAC + AMSA + filgrastim (third consolidation), in two consecutive cohorts of patients with AML CR1 receiving treatment according to a joint protocol. Group A: 18 patients, aged 41 (21-65) years, were mobilised with mini-ICE (idarubicin 8 mg/m(2) + cytarabine 800 mg/m(2) + etoposide 1

Performance of marker-based relatedness estimators in natural populations of outbred vertebrates

Knowledge of relatedness between pairs of individuals plays an important role in many research areas including evolutionary biology, quantitative genetics, and conservation. Pairwise relatedness estimation methods based on genetic data from highly variable molecular markers are now used extensively as a substitute for pedigrees. Although the sampling variance of the estimators has been intensively

The late Rhaetian transgression in southern Sweden: Regional (and global) recognition and relation to the Triassic-Jurassic boundary

Palynological investigations of Rhaetian outcrops and drillcores in combination with subsurface data from wells in Scania, southern Sweden, have revealed the presence of marine dinoflagellate cysts in sedimentary strata that were previously considered to have been deposited in a mainly terrestrial environment. Two distinct dinocyst events are identified. One older event where persistent, rare to c

Endocrinological late complications after hematopoietic SCT in children

The main challenge for a pediatric hemato-oncologist today is to obtain a cure for the sick child with the minimum of treatment-related complications. Children on their way to achieving adulthood face many risks after hematopoietic SCT (HSCT). Continuous follow-up includes assessment of organ function, focus on vaccinations and screening for secondary malignancies. Updated treatment protocols are

Markedly reduced chronic nociceptive response in mice lacking the PAC1 receptor

The neuropeptide pituitary adenylate cyclase activating polypeptide (PACAP) has been proposed to have a role in nociception. Here we have used the formalin test, thermal laser stimulation and mechanical von Frey stimulation to investigate possible alteration of PAC1-/- mice nociceptive behaviour. Our finding, that PAC1-/- mice have a substantial, 75% decrease in nociceptive response during the lat

The relationship between local extinctions of grassland butterflies and increased soil nitrogen levels

In contrast to many other western European countries, the knowledge about trends in the Swedish butterfly fauna is poor. We studied the effects of habitat and species characteristics on species turnover in 13 grassland sites in southern Sweden by comparing species richness and compositions at two separate occasions with an interval of 21 years. The mean number of species per site decreased from 30

Bullying at work, health outcomes, and physiological stress response

The relationships among bullying or witnessing bullying at work, self-reported health symptoms, and physiological stress reactivity were analysed in a sample of 437 employees (294 women and 143 men). Physiological stress reactivity was measured as cortisol in the saliva. Of the respondents, 5% of the women (n=15) and 5% of the men (n=7) reported bullying, whereas 9% of the women (n=25) and 11% of

Registration of abdominal CT and SPECT images using Compton scatter data

The present study investigates the possibility to utilize Compton scatter data for registration of abdominal SPECT images. A method for registration to CT is presented, based on principal component analysis and cross-correlation of binary images representing the interior of the patient. Segmentation of scatter images is performed with two methods, thresholding and a deformable contour method. To a

Interaction Between Renal Function and Microalbuminuria for Cardiovascular Risk in Hypertension The Nordic Diltiazem Study

We investigated whether renal function and microalbuminuria are independent predictors and whether any interaction exists between them, regarding future cardiovascular disease in hypertensive patients (n=10 881) followed for 4.5 years. The primary end points (PEs) were fatal and nonfatal myocardial infarction and stroke and other cardiovascular deaths. Creatinine and glomerular filtration rate (GF

Towards an orientation-distribution-based multi-scale approach for remodelling biological tissues

The mechanical behaviour of soft biological tissues is governed by phenomena occurring on different scales of observation. From the computational modelling point of view, a vital aspect consists of the appropriate incorporation of micromechanical effects into macroscopic constitutive equations. In this work, particular emphasis is placed on the simulation of soft fibrous tissues with the orientati

Nanoconfinement-enhanced conformational response of single DNA molecules to changes in ionic environment

We show that the ionic environment plays a critical role in determining the configurational properties of DNA confined in silica nanochannels. The extension of DNA in the nanochannels increases as the ionic strength is reduced, almost tripling over two decades in ionic strength for channels around 100x100 nm in dimension. Surprisingly, we find that the variation of the persistence length alone wit