3D-cellodling - ett steg närmare verkligen Den traditionella odlingen av celler sker i Petriskålar/flaskor. Detta system har varit och är fortfarande ett bra verktyg för att få en riktlinje och förstå hur celler, däribland även cancer celler, svarar på t.ex. behandlingar av olika substanser. Begränsningen med detta system är att cellerna växer i 2D, d.v.s. bara i ett lager bredvid varandra. Men i

Using pictures of patient data to predict hospitalization Predicting patient hospitalization has been a major objective of health care providers due to its impact on patients’ life quality. These benefits are demonstrated in driving down health care cost in addition to lowering mortality rates and complications due to unplanned hospitalizations. Like any other patients, dialysis patients experi

Purpose: To estimate the impact upon Health-Related Quality of Life (HRQOL) associated with Type 1 Diabetes Mellitus (T1DM), both with and without associated diabetic complications, for enabling calculation of utility values – Quality of Life Weights (QLW) – for populations with T1DM. Method: Two cohorts from Northern Sweden, one of T1DM patients and one of a general population, were given survey

The restriction modification enzyme system is a vital bacterial defense system against invading phages. Restriction modification system consists of a restriction enzyme and a methyltransferase enzyme that work in a complementary fashion to cut foreign DNA and at the same time methylates and protects host DNA. Recognition site sequence is usually specific for each restriction enzyme. Restriction Re

Bekämpningsmedel kan påverka könsfördelning hos vilda bin Neonikotinoider ingår i många av världens mest använda insektsbekämpningsmedel. Olycksbådande resultat från ett flertal vetenskapliga studier har gjort att man nu börjat ifrågasätta de effekter neonikotinoider har på nyttoinsekter som honungsbin, vilda bin, humlor samt andra harmlösa insekter. I denna studie undersöker man hur en vanlig ar

In this master thesis, the topic of energy storage connected to concentrator photovoltaic power production is assessed. The end goal is to propose the optimal energy storage technology and its sizing, regarding power and energy capacity, for an existing concentrator photovoltaic power plant. The plant is located in the province of Algarve in Portugal, the installed production capacity is 4.5 MW, a

This thesis suggests and tests two methods for categorizing instruments in a musical signal. The first method involves spectral analysis and the magnitude spectrum, analysing the structure of pitches and overtones and how the amplitude of those changes over time. The second method involves cepstrum analysis and especially the, for speech recognition popular method computing the Mel Frequency Cepst

In order to understand how the Pleistocene glacial cycles have influenced the diversification in the Reed Bunting (Emberiza schoeniclus) subspecies complex, we conducted a multilocus phylogeographic study. We analysed DNA sequences from 32 breeding populations, covering the species’ Palearctic distribution, and used population genetics, phylogenetic and coalescent methods to uncover genetic struct

This paper investigates the impact of HIV prevalence on schooling achievement. By associating data of schooling test results, for seven countries in Sub-Saharan Africa, with regional measures of HIV prevalence for 70 different regions, I find evidence that a general increase in HIV prevalence of about 1%, lowers general test score results of about 1% of a standard deviation from the mean. Endogene

Children affected by the multisystem genetic disorder Hutchinson-Gilford Progeria Syndrome look prematurely aged, suffer from elderly-related conditions and die during adolescence due to cardiovascular complications. The cause of the disease is single point gain-of-function mutations in the LMNA gene, which encodes the lamin A and lamin C proteins, major components of the nuclear lamina. These mut

Heart failure is one of the most common reasons for death in the modern society. As the field of tissue engineering is evolving, cardiac patches as treatment for suffering patients holds future promise. However, methods for efficient purification of cardiomyocytes from biopsies are lacking, hindering the development of such solutions. Here a novel method for separation of cardiomyocytes in a micro

At the Department of Biomedical Engineering work has been done on micro- dispensers - micro-mechanical devices used for handling extremely small volumes of fluid, which is used in the pharmacological industry. The main part of these devices is a membrane which moves distances on the order of micrometers, and vibrates with natural modes at frequencies over 10kHz, and there was a desire to image the

Epithelial ovarian carcinoma is a gynecological cancer with the highest death incidence worldwide. It is treated with surgery and chemotherapeutic drugs: platinum or taxane. However, around 80% of patients have disease progression into more aggressive and chemoresistant cancer. Mitochondria are structures inside both normal and cancer cells which are central to the cell´s metabolism by supplying e

The interest of this research lies in the nexus between the state and the individual in providing social care for people searching asylum in Finland. The study explores the experiences of host families involved in offering home accommodation for asylum seekers. More specifically, it aims to understand the subjective role that host families assign to themselves when providing social care for this t

Interactions between obesity and breast cancer Breast cancer and obesity are both diseases that are afflicting more and more women at an alarming rate in the Western world. In this project we examined how fat cells under different obesity-associated conditions, influenced breast cancer cells. We showed that breast cancer cells are affected by fat cells regarding both cell growth and movement. B

Abstract: This thesis is an anthropological study on how a group of people suffering from Posttraumatic Stress Disorder [PTSD] construct meaning in a community center in Copenhagen. The specific aim of this thesis is to investigate how place can be understood as a factor that plays into well-being and recovery. Based on a case study of a Danish community health center, this study shows how users

Helicobacter pylori is an important pathogen inhabiting the human stomach. H. pylori binds plasminogen, a 90 kDa glycoprotein secreted by liver cells, and utilizes it for enhancing virulence. Surface receptors on the bacteria recognize plasminogen that is then activated into plasmin by host factors. The active plasmin can degrade a range of host proteins including proteins of the extracellular mat

Globalization has led to an increase in competition between places in hopes of attracting mobile capital and investments as well as new inhabitants and tourists. Nature-based tourism has become one of the most steadily growing markets for tourism in Europe. In order for a place to be attractive it has to have a brand that can be constructed depending what sort of resources a place has. A place is

My master degree project started with an open brief, setting out to explore new possibilities within healthcare in relation to the benefits of IoT. By looking at medical trends, cutting edge diagnostic technologies, hypothesis about the future and by interviewing patients and medical personnel a couple of interesting project directions emerged. A decision was made to focus on prevention and one to

Avian malaria parasites can have severe fitness effects on the host although most infections seem to be mild. Some of the avian malaria parasites are host specific and infect specific bird species while others infect a wide range of species. Avian malaria can serve as a natural model system for studies of the effect of environmental change on parasites distribution patterns. The global changes of