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Background: Glioblastoma is the most common primary malignant brain tumor in adults. Elevated interstitial fluid pressure (IFP) within the tumor restricts drug uptake and contributes to the dismal prognosis. Antisecretory factor (AF) is an endogenous protein that possesses antisecretory and immunomodulating properties. In vivo, AF can reduce elevated IFP. There are two AF-enhancing products; Salov
