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We evaluated the durability of autologous chondrocyte transplantation grafts in 61 patients treated for isolated cartilage defects on the femoral condyle or the patella and followed up for a mean of 7.4 years (range, 5 to 11). Durability was determined by comparing the clinical status at the long-term follow-up with that found 2 years after the transplantation. After 2 years, 50 of the 61 patients
Fruit and vegetable processors, faced with the challenge of gaining and maintaining a healthy position in the competitive fruit and vegetable sector, are optimising traditional processes towards product quality. Using frozen potatoes as a case study, the aim of this study was to evaluate the potential of improving the texture of potatoes by modifying the processing conditions. The texture of proce
Reef biostromes and related facies from the upper part of Wenlock and from Ludlow were investigated in order to account for their formation, their palaeoecology and biology. In the Hemse Group of Ludlow age, all studied biostromes comprise a low diversity fauna where one or few species dominates. These biostromes are divided into Kuppen type biostromes, Grogarnshuvud type biostromes and Sjaustreha
A new method for characterization of atrial fibrillation in the surface ECG is presented which is based on a time-frequency distribution of the QRST-cancelled signal. With the present method, information regarding temporal variations in fibrillation frequency and waveform shape is extracted and investigated. The method is evaluated on a database including 182 recordings (obtained during resting co
1. Salmeterol is a potent, selective and long acting beta 2-adrenoceptor agonist. In vitro, salmeterol exerts 'reassertion' relaxation of airways smooth muscle. Reassertion relaxation refers to the capacity of salmeterol to cause repeated functional antagonism of induced contraction when airway smooth muscle is intermittently exposed to, then washed free from, beta-adrenoceptor antagonists such as
In this study we have developed and validated a novel approach of transgene regulation in the brain. By using lentiviral vectors that incorporate promoters of genes that are up-regulated during different pathological states, we were able to regulate transgene expression in accordance with the disease process. When using a glial fibrillary acidic protein promoter, efficient disease regulation in gl
The electrochemistry of some copper-containing proteins and enzymes, viz. azurin, galactose oxidase, tyrosinase (catechol oxidase), and the "blue" multicopper oxidases (ascorbate oxidase, bilirubin oxidase, ceruloplasmin, laccase) is reviewed and discussed in conjunction with their basic biochemical and structural characteristics. It is shown that long-range electron transfer between these enzymes
In a search for inhibitors of the inducible tumor necrosis factor-alpha (TNF-alpha) promoter activity and synthesis, a new chlorinated cyclopentenone was isolated from fermentations of the ascomycete Mollisia melaleuca. The structure was determined by a combination of spectroscopic techniques. The compound blocked the inducible human TNF-alpha promoter activity and synthesis with IC50-values of 2.
An axillary brachial plexus nerve block by a transarterial approach is commonly used to achieve regional anaesthesia for hand surgery. We designed a retrospective study to evaluate efficacy and safety of the technique for acute and elective operations. Anaesthetic records of 189 of all 5520 patients (1996-2000) who had axillary brachial plexus blocks for hand surgery were reviewed, and results com
The level scheme of 87Mo was investigated with the reaction Ni-58(S-32, 2pn) at projectile energies of 110-130 MeV and the reaction Ca-40(Cr-50, 2pn) at 170 MeV. Extensive spectroscopic information was collected including gamma-gamma and neutron-gated gamma-gamma-coincidences as well as coincidences with identified 87Mo residues. Level lifetimes were studied with the RDDS and DSA methods. The angu
Sedum sarmentosum Bunge possesses excellent anti-inflammatory properties and was used in the treatment of inflammatory diseases. The aim of the present study was to investigate the efficiency of Sedum sarmentosum Bunge extract (SSBE) on severe acute pancreatitis-associated (SAP-associated) acute lung injury (ALI) in rats and to explore the underlying mechanisms. Here, we used a sodium taurocholate
With the aim of assessing the extent and nature of naturalistic studies involving vulnerable road users, a systematic literature review was carried out. The purpose of this review was to identify studies based on naturalistic data from VRUs (pedestrians, cyclists, moped riders and motorcyclists) to provide an overview of how data was collected and how data has been used. In the literature review,
Developing systems by integrating Open Source Software (OSS) is increasingly gaining importance in the software industry. Although the literature claims that this approach highly impacts Requirements Engineering (RE) practices, there is a lack of empirical evidence to demonstrate this statement. To explore and understand problems and challenges of current system requirement–OSS component matching Developing systems by integrating Open Source Software (OSS) is increasingly gaining importance in the software industry. Although the literature claims that this approach highly impacts Requirements Engineering (RE) practices, there is a lack of empirical evidence to demonstrate this statement. To explore and understand problems and challenges of current system requirement–OSS component matching
This Letter presents evidence for single top-quark production in the s-channel using proton–proton collisions at a centre-of-mass energy of 8 TeV with the ATLAS detector at the CERN Large Hadron Collider. The analysis is performed on events containing one isolated electron or muon, large missing transverse momentum and exactly two b-tagged jets in the final state. The analysed data set corresponds
The ATLAS experiment at the CERN Large Hadron Collider has performed searches for new, heavy bosons decaying to WW, WZ and ZZ final states in multiple decay channels using 20.3 fb−1 of pp collision data at s=8 TeV. In the current study, the results of these searches are combined to provide a more stringent test of models predicting heavy resonances with couplings to vector bosons. Direct searches
