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Migraine is a neurovascular disorder characterized by recurrent unilateral headaches accompanied by nausea, vomiting, photophobia and phonophobia. Current theories suggest that the initiation of a migraine attack involves a primary event in the central nervous system (CNS), probably involving a combination of genetic changes in ion channels and environmental changes, which renders the individual m
Objectives: This study aimed to investigate the most important consequences of diabetes medication, as measured by the patients' willingness to pay (WTP). Research design and methods: People in Sweden were recruited using existing nationwide e-mail panels if they were adults (>= 18 years) with type 2 diabetes and were receiving pharmacological anti-diabetes treatment(s). Data were collected electr
New data regarding a positive association between smoking and risk of epithelial ovarian cancer (EOC), especially the mucinous tumor type, has started to emerge. The purpose of this study was to examine the association between different measures of smoking exposures and subtypes of EOC in a large cohort of women from 10 European countries. The European Prospective Investigation into Cancer and Nut
Epidemiologic studies have reported that moderate alcohol consumption is inversely associated with the risk of renal cancer. However, there is no information available on the associations in renal cancer subsites. From 1992 through to 2010, 477,325 men and women in the European Prospective Investigation into Cancer and Nutrition cohort were followed for incident renal cancers (n=931). Baseline and
Background. In a population study using TRUE Test (R), we noted late reactions to p-tert-butylphenol-formaldehyde resin (PTBP-FR) in 0.5% of subjects tested. Objectives. In order to explore possible test sensitization, differences in the contents of sensitizers within PTBP-FR in test preparations for TRUE Test (R) and Finn Chambers (R) were analysed. Subjects allergic to PTBP-FR and subjects with
The compound CaAgGe and its Mn-substituted derivative CaMn0.07Ag0.93Ge were synthesized by reaction of the element mixtures at high temperature. Their structures were refined from single-crystal X-ray diffraction data. CaAgGe crystallizes in the isomorphic (i(3)) superstructure of the TiNiSi type (CaCuGe type). The LMTO band structure calculations predicted the CaAgGe phase to be metallic. In addi
The aim of this study was to investigate the microvascular responses in the skin, to local heat, iontophoretically administered acetylcholine and to sodium nitroprusside in relation to cardiovascular damage in patients with systemic lupus erythematosus (SLE) and matched controls. We also wanted to examine if the ongoing medication in SLE patients influenced this vascular response. We investigated
Objectives. To study possible nerve regeneration of a damaged auditory nerve by the use of stem cell transplantation. Methods. We transplanted HNPCs to the rat AN trunk by the internal auditory meatus (IAM). Furthermore, we studied if addition of BDNF affects survival and phenotypic differentiation of the grafted HNPCs. A bioactive nanofiber gel (PA gel), in selected groups mixed with BDNF, was ap
We quantified the semantic content in adolescents’ descriptions of positive and negative life events and studied how these descriptions are related to the assessment Subjective Well-Being (SWB) at two points in time. The semantic content of the descriptions was quantified by Latent Semantic Analysis (LSA). LSA is a computational method based on algorithms stemming from computational linguistics, w
There exists compelling experimental evidence in numerous systems for logarithmically slow time evolution, yet its full theoretical understanding remains elusive. We here introduce and study a generic transition process in complex systems, based on nonrenewal, aging waiting times. Each state n of the system follows a local clock initiated at t = 0. The random time tau between clock ticks follows t
β-Mannanases are involved in the conversion and modification of mannan-based saccharides. Using a retaining mechanism, they can, in addition to hydrolysis, also potentially perform transglycosylation reactions, synthesizing new glyco-conjugates. Transglycosylation has been reported for β-mannanases in GH5 and GH113. However, although they share the same fold and catalytic mechanism, there may be d
A detailed stratigraphical, palaeoecological and geomorphological reconstruction of a fjord head on South Georgia (Husvik, Stromness Bay) is presented. Six sites were chosen to reconstruct the lithostratigraphy of the area by means of coring. A maximum depth of 11m was attained and the sediments encountered vary from coarse gravel over sands to fine silts with, in some cases, intercalated peat lay
Objective. To investigate gender differences in the association between self-rated health (SRH) and impaired glucose tolerance (IGT) in subjects unaware of their glucose tolerance. Design. A cross-sectional population-based study. Setting. The two municipalities of Vara and Skovde in south-western Sweden. Subjects. A total of 2502 participants (1301 women and 1201 men), aged 30-75, were randomly s
Purpose The purpose is to outline the conditions for a new service system in healthcare, which will be able to match the available capacity in and between healthcare units in order to match the need of care for the patients. Methodology By drawing on statements from patients, experiences from similar services (a literature review), empirical research into the effects of the reforms on free choice
In this study, the potential of a chitosan-agarose-gelatin (CAG) cryogel scaffold for the repair of subchondral cartilage defects was explored in female New Zealand white rabbits. Custom-made CAG cryogel scaffold was implanted in a surgically created subchondral defect (diameter of 4 mm, depth of 4 mm) in knee joint of rabbit. The repair of the subchondral defect was evaluated at regular time inte
We consider a class of pseudodifferential evolution equations of the form u(t) + (n(u) + Lu)(x) = 0, in which L is a linear smoothing operator and n is at least quadratic near the origin; this class includes in particular the Whitham equation. A family of solitary-wave solutions is found using a constrained minimization principle and concentration-compactness methods for noncoercive functionals. T
A series of polystyrene-clay nanocomposites, based on two natural clay types (Na-Montmorillonite and Hectorite) and two synthetic clays (Laponite and Li- Fluorohectorite), were prepared via in situ intercalative polymerization after surface modification with an organic ammonium cation (CTAB). The structural characteristics of the organically modified clays as well as the nanocomposites were invest
Anamestic inhibitors represent the major complication of haemophilia therapy now that clotting factor concentrates are virtually free of pathogen-transmission risk. Conventional clotting factor replacement is usually insufficient to prevent or treat bleeding in a haemophilia patient with a high responding inhibitor so that alternative treatment with bypassing agents is required. Despite their rela
