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A Phase 2a Trial Investigating the Safety and Tolerability of the Novel Cortical Enhancer IRL752 in Parkinson's Disease Dementia

Background: IRL752 is a novel small-molecule compound that acts to regioselectively enhance norepinephrine, dopamine, and acetylcholine neurotransmission in the cerebral cortex. Objective: The primary objective of the trial was to investigate the safety and tolerability of IRL752 in patients with Parkinson's disease and dementia. Methods: Patients with Parkinson's disease and dementia were randomi

Climate warming and heat waves alter harmful cyanobacterial blooms along the benthic–pelagic interface

In addition to a rise in mean air and water temperatures, more frequent and intense extreme climate events (such as heat waves) have been recorded around the globe during the past decades. These environmental changes are projected to intensify further in the future, and we still know little about how they will affect ecological processes driving harmful cyanobacterial bloom formation. Therefore, w

Retinal topography in two species of flamingo (Phoenicopteriformes : Phoenicopteridae)

In this study, we assessed eye morphology and retinal topography in two flamingo species, the Caribbean flamingo (Phoenicopterus ruber) and the Chilean flamingo (P. chilensis). Eye morphology is similar in both species and cornea size relative to eye size (C:A ratio) is intermediate between those previously reported for diurnal and nocturnal birds. Using stereology and retinal whole mounts, we est

Fetal exposure to paternal smoking and semen quality in the adult son

Background: The negative impact of maternal smoking during pregnancy on offspring semen quality is well established. Less is known about the impact of paternal smoking. Methods: We estimated differences in semen parameters and testicle size according to paternal smoking in 772 adult sons of women enrolled in the Danish National Birth Cohort when pregnant. Parents’ smoking was reported around gesta

RIFM fragrance ingredient safety assessment, 4-hydroxy-3-methyloctanoic acid lactone, CAS Registry Number 39212-23-2

RIFM fragrance ingredient safety assessment, α,2,2,3-tetramethylcyclopent-3-ene-1-butyraldehyde, CAS Registry Number 65114-03-6

RIFM fragrance ingredient safety assessment, hexanoic acid, CAS Registry Number 142-62-1

RIFM fragrance ingredient safety assessment, 2-hydroxyethyl phenoxyacetate, CAS Registry Number 1984-60-7

RIFM fragrance ingredient safety assessment, cinnamyl benzoate, CAS Registry Number 5320-75-2

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RIFM fragrance ingredient safety assessment, octanoic acid, CAS Registry Number 124-07-2

RIFM fragrance ingredient safety assessment, 2-(4-methylphenoxy)-N-(1H-pyrazol-3-yl)-N-(thiophen-2-ylmethyl)acetamide, CAS Registry Number 1374760-95-8

Global Stroke Statistics 2019

Background: Data on stroke epidemiology and availability of hospital-based stroke services around the world are important for guiding policy decisions and healthcare planning. Aims: To provide the most current incidence, mortality and case–fatality data on stroke and describe current availability of stroke units around the world by country. Methods: We searched multiple databases (based on our exi

RIFM fragrance ingredient safety assessment, 1-(5,5-dimethyl-1-cyclohexen-1-yl)pent-4-en-1-one, CAS Registry Number 56973-85-4

RIFM fragrance ingredient safety assessment, cis-4-(isopropyl)cyclohexanemethanol, CAS Registry Number 13828-37-0

RIFM fragrance ingredient safety assessment, 5-methyl-3-heptanone, CAS Registry Number 541-85-5

RIFM fragrance ingredient safety assessment, 2-(3,7-dimethyl-2,6-octadienyl)cyclopentanone, CAS Registry Number 68133-79-9

RIFM fragrance ingredient safety assessment, p-cresyl salicylate, CAS Registry Number 607-88-5

RIFM fragrance ingredient safety assessment, 1-oxaspiro[4.5]deca-3,6-diene, 2,7-dimethyl-10-(1-methylethyl)-, CAS Registry Number 89079-92-5

RIFM fragrance ingredient safety assessment, ethyl 3-hydroxybutyrate, CAS Registry Number 5405-41-4