Objectives. To evaluate long-term changes in acetylcholinesterase (AChE) activity in CSF and blood following donepezil treatment in relation to the concentration of donepezil and cognition in AD patients. Methods. CSF or blood (or both) samples of a total of 104 patients with mild AD were used [MMSE score 23 +/- 0.4; age 75 +/- 1 years (mean +/- SEM); n = 53 for CSF and n = 51 for plasma/red blood

To mimic the electron donor side of Photosystem II (PSII), a number of supramolecular model complexes have been designed and synthesized. Ruthenium(II) tris-bipyridyl complexes have been used in most cases as photosensitizers, mimicking the function of P-680 in PSII. As electron donors, monomeric and dimeric manganese complexes and tyrosine have been introduced into the supramolecular systems, mod

Sulfur-containing compounds are used as rescue agents to protect normal tissue from the toxic side effects of cis-[PtCl2(NH3)(2)] (cisplatin) without affecting its anti-tumour activity. Reactions of the model complexes [Pt(dien)Cl](+) (1) and [Pt(dien)(GSMe)](2+) (2) (GSMe = S-methylglutathione) with the rescue agents glutathione (GSH), thiourea, thiosulfate, and diethyldithiocarbamate (DDTC) have

Lifetimes of high spin states in the three A = 89 isobars Nb-89, (89)MO and (TC)-T-89 have been measured via the Recoil Distance Doppler Shift technique and the fusion evaporation reactions Ni-58(Cl-35, xnypz alpha) at 120 MeV beam energy. Reduced transition probabilities for about 50 gamma transitions were extracted. The experimental branching ratios in Mo-89 and reduced transition probabilities

Ninety-eight patients, 56 suffering according to DSM-IV of unipolar depression and 42 of somatoform disorders, were compared on the Beck Depression Inventory (BDI) total scale, the subscale of Somatic complaints and the Cognitive-affective subscale. A factor analysis performed on the total group revealed five factors used to determine new subscales: Depressed mood, Somatic manifestations, Loss of

With the characterization of the total genomes of Arabidopsis thaliana and Oryza sativa, several putative plasma membrane components have been identified. However, a lack of knowledge at the protein level, especially for hydrophobic proteins, have hampered analyses of physiological changes. To address whether protein complexes may be present in the native membrane, we subjected plasma membranes is

We argue that ine + e –-annihilation (including -decay) deuteron production should be given by the overlap of the deuteron wave function with the wave function of apn-pair. The production rate depends sensitively upon the size of the production region. Taking into account the strong correlation between protons and neutrons, experimental results for -decay are consistent with the size expected in t

Intervju med Jan Troell om hans filmkarriär, berättarteknik och särskilt hans då aktuella film Så vit som en snö

Tidal marshes have recently been shown to be important biogenic Si recycling surfaces at the land-sea interface. The role of vegetation in this recycling process has not yet been quantified. In situ and ex situ decomposition experiments were conducted with Phragmites australis stems. In a freshwater tidal marsh, litterbags were incubated at different elevations and during both winter and summer. B

The radioactive decay of 238U and 232Th has recently been used to determine ages for some of the oldest stars in the Universe. This has highlighted the need for accurate observational constraints on production models for the heaviest r-process elements which might serve as stable references, notably osmium and iridium. In order to provide a firmer basis for the observed abundances, we have perform

This thesis will describe the clinical phenotypes, with emphasis on electrophysiology, in patients with different hereditary eye diseases and to further evaluate and modify the mfVEP technique for clinical use. Bothnia Dystrophy is a tapetoretinal disorder with a mutation in the RLBP1 gene. Early in the disease the fundus may have a normal appearance. The full-field ERG demonstrates an absence of

The complex salt (ionic surfactant + polymeric counterion) cetyltrimethylammonium polyacrylate (CTAPA) has been synthesized, and its aqueous mixtures with cetyltrimethylammonium bromide (CTABr) have been studied. These mixtures differ from conventional oppositely charged polymer/surfactant mixtures in that the conventional counterion of the polyion (usually sodium, for the polyacrylate) is absent,