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Popular Abstract in Swedish Var tredje svensk kommer någon gång under sitt liv att drabbas av cancer. Ärftlighet är en stark riskfaktor för såväl tjocktarmscancer (kolorektal cancer) som för äggstockscancer (ovarialcancer). Vid ärftlig cancer har man ärvt en förändring i arvsmassan (DNA:t), och en medfödd defekt finns således i alla kroppens celler. Vid Lynch syndrom, ett ärftligt cancersyndrom, fLynch syndrome (hereditary nonpolyposis colorectal cancer) is one of the most common hereditary cancer syndromes and predisposes to several cancer types, including cancer of the colorectum, endometrium and ovaries. Cancer develops at an early age and one third of the individuals are affected by a metachronous cancer. Recognition of families with Lynch syndrome is important since this allows inclus

OBJECTIVE-Phosphoinositide 3-kinase (PI3K) is a major effector in insulin signaling. rs361072, located in the promoter of the gene (PIK3CB) for the p110 beta subunit, has previously been found to be associated with homeostasis model assessment for insulin resistance (HOMA-IR) in obese subjects. The aim was to investigate the influence of rs361072 on in vivo glucose metabolism, skeletal muscle PI3K

Wnt5a is a non-canonical secreted glycoprotein of the Wnt family that plays an important role in cancer development and progression. Previous studies report that Wnt5a is upregulated in prostate cancer and suggested that Wnt5a affects migration and invasion of prostate tumor cell. This study aimed to evaluate the prognostic value of Wnt5a protein expression in prostate cancer tissue and its potent

Optical mapping of genomic DNA is of relevance for a plethora of applications such as scaffolding for sequencing and detection of structural variations as well as identification cif pathogens like bacteria and viruses. For future clinical applications it is desirable to have a fast and robust mapping method based on as few steps as possible. We here demonstrate a single-step method to obtain a DNA

Formation of the hematopoietic stem cell (HSC) niche in bone marrow (BM) is tightly associated with endochondral ossification, but little is known about the mechanisms involved. We used the oc/oc mouse, a mouse model with impaired endochondral ossification caused by a loss of osteoclast (OCL) activity, to investigate the role of osteoblasts (OBLs) and OCLs in the HSC niche formation. The absence o

The aim of this paper is to show that there is a reciprocal dependency relationship between social cognition and social ontology. It is argued that, on the one hand, the existence conditions of socially meaningful objects and of social groups are about subjects’ social cognitive processes and interactive patterns and, on the other hand, social cognitive processes and interactive patterns are modul

Denna artikel är en reflektion över högskolepedagogikens historia, nutid och framtid. I den identifieras två strategier som kan ses som syftet med en högskolepedagogisk utbildning för universitetslärare: motstånd mot negativa konsekvenser av den oerhörda förändring som skett av universiteten de senaste decennierna, samt anpassning till en överlevnad och sökandet efter styrka i dessa förändringar.

The weighted oscillator strengths (gf) and lifetimes for S VIII presented in this work were obtained by a multiconfigurational Hartree-Fock relativistic approach. In this calculation, the electrostatic energy parameters were optimized by a least-squares procedure in order to improve the adjustment to experimental energy levels. The values for gf and lifetimes were then calculated on the basis of t

Review of Practical Multivariate Analysis, Fifth Edition. By A. Afifi, S. May & V.A. Clark. Boca Raton, FL: Chapman & Hall/CRC. 2011. 537 pages. UK£46.99(hardback). ISBN 978-1-4398-1680-6.

1. We assessed the terrestrial export of organic carbon, which effectively supported aquatic bacterial production (BP), from small boreal catchments during spring flood. We analysed stream runoff from nine small catchments with different proportions of peat mires and coniferous forests by monitoring the dissolved organic carbon (DOC) flux in combination with conducting bacterial bioassays. 2. Mu

By studying how nanowires lying on a surface bend when pushed by an atomic force microscopy tip we are able to measure the friction between them and the substrate. Here, we show how the friction between InAs nanowires and an insulating silicon nitride layer varies when a dc voltage is applied to the tip during manipulation. The bias charges the capacitor formed by the wire and the grounded silicon

Background: Whey protein increases postprandial serum insulin levels. This has been associated with increased serum levels of leucine, isoleucine, valine, lysine, threonine and the incretin hormone glucose-dependent insulinotropic polypeptide (GIP). We have examined the effects of these putative mediators of whey's action on insulin secretion from isolated mouse Langerhans islets. Methods: Mouse p

The first measurement of diffractive scattering of quasi-real photons with large momentum transfer gamma p -> gamma Y, where Y is the proton dissociative system, is made using the H1 detector at HERA. The measurement is performed for initial photon virtualities Q(2) < 0.01 GeV2. Single differential cross sections are Measured as a function of W, the incident photon-proton centre of mass energy, an

We have performed a McStas optimization of the primary spectrometer for a generic 40 m long, cold-neutron triple-axis spectrometer with a doubly focusing monochromator. The optimal design contains an elliptically focusing guide, a virtual source point before a low-grade PG monochromator, and non-equidistant focusing at the monochromator. The flux at 5 meV shows a gain factor 12 over the "classical

Time perspective (TP) refers to individuals’ ways of constructing, reconstructing, and relating the psychological concepts of past, present,and future, and provides individuals with a coherence of experiences over time. In the present study, the relationships among five TPs (past negative, past positive, present fatalistic, present hedonistic, and future) were studied in a student sample (N = 280)

Cylinder pressure sensors provide detailed information on the diesel engine combustion process. This paper presents a method to use cylinder-pressure data for prediction of engine emissions by exploiting data-mining techniques. The proposed method uses principal component analysis to reduce the dimension of the cylinder-pressure data, and a neural network to model the nonlinear relationship betwee

The European Society of Cardiology recommends that patients with >10% area of ischemia should receive revascularization. We investigated inter-observer variability for the extent of ischemic defects reported by different physicians and by different software tools, and if inter-observer variability was reduced when the physicians were provided with a computerized suggestion of the defects.