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Cross-linking mass spectrometry (CLMS) provides distance constraints to study the structure of proteins, multiprotein complexes and protein-protein interactions which are critical for the understanding of protein function. CLMS is an attractive technology to bridge the gap between high-resolution structural biology techniques and proteomic-based interactome studies. However, as outlined in this re
Background: Human rhinoviruses (HRVs) commonly precipitate asthma exacerbations. Toll-like receptor 3, an innate pattern recognition receptor, is triggered by HRV, driving inflammation that can worsen asthma. Objective: We sought to evaluate an inhibitory mAb to Toll-like receptor 3, CNTO3157, on experimental HRV-16 inoculation in healthy subjects and asthmatic patients. Methods: In this double-bl
The driving force behind the current global type 2 diabetes epidemic is insulin resistance in overweight and obese individuals. Dietary factors, physical inactivity, and sedentary behaviors are the major modifiable risk factors for obesity. Nevertheless, many overweight/obese people do not develop diabetes and lifestyle interventions focused on weight loss and diabetes prevention are often ineffec
Labour market outcomes for immigrants in general is a well researched field, but the mechanisms behind labour market mismatches among immigrants post-migration is still in need of empirical research. Using a unique and newly compiled dataset on Swedish immigrants, also containing pre-migration occupational and educational information data, this study aims makes use of maximum likelihood models to
Using a newly digitised historical dataset on clean water technologies in Swedish cities, this study tries to find the causal effect (and the magnitude of this effect) of the introduction of clean water technology on mortality in urban areas. Using urban mortality data on a county level, and clean water access data on city level, both OLS, fixed effects, and difference-in-differences models are tr
