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Ximelagatran is the first oral agent in a new class of direct thrombin inhibitors and is under investigation for the prevention and treatment of a range of thromboembolic disorders. Atrial. fibrillation (AF) is associated with a markedly increased risk of stroke and, while study results have consistently demonstrated that anticoagulant therapy with warfarin reduces this risk, there are substantial

Abstract in Danish Infliximab er effektiv ved reumatoid artritis (RA), men behandlingssvigt er hyppige. Sera fra 106 RA-patienter monitoreredes med en radioimmunoassay (RIA) for funktionel infliximab og en RIA for anti-infliximab-antistof. S-infliximab varierede betydeligt, f.eks. 0-22 μg/ml forud for tredje infusion, og efter seks måneder var 44% antistofpositive. Lav S-infliximab var forbundet mRemicade/infliximab is effective in rheumatoid arthritis (RA), but response failure is frequent. Sera from 106 RA patients were monitored using an RIA for functional infliximab and an RIA for anti-infliximab antibody (Ab). S-infliximab varied considerably, e.g. 0-22 microg/ml before the 3rd infusion, and 44% were Ab-positive after 6 months. Low s-infliximab was associated with Ab development and l

Several monouranium and diuranium polyhydride molecules were investigated using quantum chemical methods. The infrared spectra of uranium and hydrogen reaction products in condensed neon and pure hydrogen were measured and compared with previous argon matrix frequencies. The calculated molecular structures and vibrational frequencies were used to identify the species present in the matrix. Major n

In order to disentangle if and when resource supply and adult and young-of-the-year (0+) fish predation affect zooplankton dynamics during spring, we monitored zooplankton during three consecutive years in a lake in southern Sweden. We also experimentally assessed 0+ fish predation rates and estimated changes in predation rates of adult fish on zooplankton. Decline in abundances of large-sized zoo

AIMS: To develop a sensitive mutation screening procedure suitable for routine analysis of the peripherin/RDS gene, and to estimate the nature and prevalence of peripherin/RDS gene mutations in Swedish patients with autosomal dominant retinitis pigmentosa. METHODS: To make the method as sensitive as possible, as many as eight segments, covering the three exons and the flanking intron sequences of

Biosensors based on whole bacterial cells and on bacterial heavy metal binding protein were used to determine the mercury concentration in soil. The soil samples were collected in a vegetable garden accidentally contaminated with elemental mercury 25 years earlier. Bioavailable mercury was measured using different sensors: a protein-based biosensor, a whole bacterial cell based biosensor, and a pl

Bostaden används mer och mer till att nyttja olika former av media, både individuellt och i grupp. Både stationär och bärbar hemelektronik har stor betydelse för hur vi möblerar och utnyttjar bostadens rum. Det gör att generellt utformade rum och flexibla rumssamband kommer att visa sig allt viktigare. Tekniken bidrar också till att det privata blir offentligt och det offentliga privat.

Background: Mutations in the PRSS1 gene explain most occurrences of hereditary pancreatitis (HP) but many HP families have no PRSS1 mutation. Recently, an association between the mutation N34S in the pancreatic secretary trypsin inhibitor (SPINK1 or PSTI) gene and idiopathic chronic pancreatitis (ICP) was reported. It is unclear whether the N34S mutation is a cause of pancreatitis per se, whether

Hittills har rättssociologi nästan uteslutande studerat rättens funktioner, utveckling och förändring inom dem samhälleliga ramar som inrättats i enlighet med den traditionella nationalstatens grundprinciper. Under de senare decennierna har det emellertid vuxit fram en omfattande metanationell verksamhet med sin egen utvecklingsmekanism och rationalitet, som i sitt verkningssätt tycks vara oberoen

Genetic engineering has been used to construct fusion proteins of Fusarium solani pisi cutinase and tryptophan-based tags, expressed in Saccharomyces cerevisiae, to increase the partitioning in aqueous two-phase systems. The separation systems were composed of thermoseparating polymers (random copolymers of ethylene oxide and propylene oxide, EOPO) and detergents (C12EOn). In this study, the fluor

This thesis concerns numerical calculations of compressible separated flows, with and without shocks, around wing sections using Large Eddy Simulations (LES). The considered geometries are the NACA 0012 wing section and the ONERA AT15A wing section. Compressible separated flows around wing sections are of considerable interest, for engineering and scientific reasons, since they involve transition,

We take our own life stories as points of departure to look at some of the ways in which women were politicized in Argentina and West Germany (our respective countries of origin), focusing on similarities as well as differences in our politicization processes. We aim at putting present discussions about global political movements into a historical perspective. We want also to illuminate the centra

A model of how to calculate the load distribution for a chain drive is presented. In the model the complete standard geometry is used without any assumptions. The rollers which are in contact with the sprockets can move freely along the tooth flanks and their positions are given be force equilibrium. Since the positions of the rollers and thereby also the load distribution are dependent on the two

Measurements are presented of inclusive charm and beauty cross sections in e(+)p collisions at HERA for values of photon virtuality Q(2) > 150 GeV2 and of inelasticity 0.1 < y < 0.7. The charm and beauty fractions are determined using a method based on the impact parameter, in the transverse plane, of tracks to the primary vertex, as measured by the H1 vertex detector. The data are divided into fo