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Macrocyclic peptides are a growing class of pharmaceuticals, due to their high target specificity and improved properties, solubility, permeability and metabolic stability compared to linear peptides. Disulfide bonds are commonly used as linkers; however, disulfide bonds are proven to be metabolically instable. This study explores alternative linkages to replace the disulfide bond for two existing
Till följd av Helsingborgs urbana expansion har hamnverksamheten successivt flyttats längre söderut, vilket lämnade kvar en serie magasinbyggnader. Magasin 405 användes tidigare som lager för gods som lossades från fartyg som passerade genom Öresund. Präglad av sitt industriella förflutna besitter byggnaden en rad arkitektoniska kvaliteter, med en robust betongstruktur dimensionerad för tunga last
The Lean Startup Methodology (LSM) has become a near-canonical heuristic for early-stage venture building, yet its empirical foundation remains thin and its applicability to artificial intelligence (AI) ventures is under-theorised. AI-native startups operate under conditions that strain the methodology’s core assumptions: outputs are probabilistic rather than deterministic, performance is continge
This article exposes the invisible sand that underpins Copenhagen’s transformation from fishing village to global city. By “following sand,” we trace how planetary material flows sustain urban expansion while entangling the city in processes of capital accumulation, class restructuring, and ecological degradation. Drawing on Science and Technology Studies (STS) approaches, yet situating them firml
In this submission, we show the role of pollinators in sustainable food production, food security, and human rights, and the negative impact of agribusiness commercialized pesticides on pollinators and on a wide range of human rights. We identify the role of judicial and nonjudicial mechanisms in preventing these pesticides’ impacts as well as on access to justice, including remedy. Ultimately, we
This contribution to the conference on Transitioning away from Fossil Fuels focuses on thematic pillar 3 which addresses the advancement of international cooperation and climate diplomacy. The Fossil Fuel Treaty Initiative represents an opportunity to align climate ambition with human rights and biodiversity stewardship. We consider this stage of the process a crucial waypoint for responding in a
Esta contribución a la Primera Conferencia Internacional sobre la Transición hacia la no proliferación de Combustibles Fósiles se centra en el pilar temático 3, relativo al avance de la cooperación internacional y la diplomacia climática. La Iniciativa del Tratado de No Proliferación de Combustibles Fósiles (en adelante, Iniciativa FFNPT, por sus siglas en inglés) representa una oportunidad para a
we propose to fully integrate EHRDs rights in the roadmap for phasing out fossil fuels with the aim to uphold a pace that is required to catalyse climate justice for the most affected peoples and territories. A phase-out fossil fuel roadmap should consider the central role they have in protecting life on Earth, safeguarding the climate and environment, thriving biodiversity and leading pathways to
The legal sphere is increasingly moving towards the metasphere, through the adoption of virtual reality technologies across legal procedures, processes, and education. This article examines how this shift affects the execution and experience of criminal justice. Drawing on procedural justice theory and sociological perspectives, it explores how metaverse-based justice reshapes human connection, co
Within digital games, the traditional role of the animal is the role of a monster (and at times even non-human animals such as the wolf or bear) to slay or run away from (Johansson & Rübsamen 2024). This presents a dichotomous relationshipbetween the representation of the animal and the human-animal interactions, in which the player is often left with few choices in how to act. In many open-w
North Atlantic winter climate variability is strongly governed by the North Atlantic Oscillation (NAO), which represents the dominant mode of atmospheric circulation variability over the North Atlantic-European sector. Variations in the NAO influence regional temperature, precipitation, storm tracks, and near-surface wind across Europe. Understanding the variability, drivers, and future changes of
