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The remarkably efficient suppression of amyloid fibril formation by the DNAJB6 chaperone is dependent on a set of conserved S/T-residues and an oligomeric structure, features unusual among DNAJ chaperones. We explored the structure of DNAJB6 using a combination of structural methods. Lysine-specific crosslinking mass spectrometry provided distance constraints to select a homology model of the DNAJ
The brain is composed of hundreds of different neuronal subtypes, which largely retain their identity throughout the lifespan of the organism. The mechanisms governing this stability are not fully understood, partly due to the diversity and limited size of clinically relevant neuronal populations, which constitute a technical challenge for analysis. Here, using a strategy that allows for ChIP-seq
Liquid-liquid flow patterns and slug hydrodynamics were experimentally studied in non-circular glass microchannels with water-butanol, water-toluene, water–oil and water-hexane systems, considering various hydraulic diameters (600 µm, 400 µm, 200 µm), inlet junctions (crossed, T) and aspect ratios (0.5, 1). The aqueous phase was the continuous phase due to the hydrophilic microchannel walls and th
The chitosan and gelatine are commonly used biopolymers for the tissue engineering applications. In the previous methods for the cryogels synthesis, multistep preparation methods using toxic cross-linking agents such as glutaraldehyde are reported. Here, we present a two-step preparation method of gelatin macroporous cryogels and one-step preparation method of chitosan or gelatin cryogels. The phy
Landscape heterogeneity is an important driver of biodiversity in agroecosystems. However, the functional heterogeneity of agricultural landscapes, taking into account the different resources that habitat patches can provide to species, has rarely been studied. In this study, we explored the effect of landscape-scale nest availability provided by permanent grasslands on wild bee communities. Wild
För 300 år sedan fanns väldiga skogar med rik biologisk mångfald i Nordamerika. Tre pionjärer som dokumenterat denna idag till stora delar försvunna värld var Mark Catesby, Alexander Wilson och John James Audubon.
The γ-radiation by electrons with the energy of ∼200 MeV in a 100μm-thick diamond crystal has been measured at the MAX-lab experimental facility, when the electrons are incident on the crystal along the 〈100〉 axis. In this case, the intensity of the -radiation with the energy ∼1–2 MeV is approximately 16 times higher than that in amorphous matter of the same thickness. Theoretical calculations bas
This paper investigates the moisture dependency of ion diffusion in binary cementitious binders with Portland cement (OPC) in combination with slag or silica fume. Resistivity measurements and calculations with a thermodynamic model, GEMS, were used to assess the unsaturated chloride diffusion coefficient. The results show that the relation between the relative diffusion coefficient and the degree
The removal of natural organic matter (NOM) from boreal lake water by a novel capillary nanofiltration (NF) membrane was predicted using a computational fluid dynamics (CFD) modelling approach. The 2-dimensional axis-symmetric model was based on a 48 m3/day NF pilot plant operating in cross-flow mode on water containing 8 mg/L total organic carbon (TOC) at fluxes ranging from 10 to 25 L/m2/h and v
Background: Almost 1/3 of heart failure patients fail to respond to cardiac resynchronization therapy (CRT). A simple clinical score to predict who these patients are at the moment of referral or at time of implant may be of importance for early optimization of their management. Methods: Observational study. A risk score was derived from factors associated to CRT response. The derivation cohort wa
In an effort to strengthen midwifery students’ learning process, written reflections during the students’ clinical practice at birth units have been applied. The aim of this study was to examine how students of midwifery experienced the writing of daily reflections on their practice at birthing units. An interview study was carried out using an inductive method with descriptive design. During 2013
This work is a proof of concept of how a sequence of industrial batch separation steps together are used to form an integrated autonomous downstream process. The sequence in this case study consisted of an anion chromatography step, virus inactivation and finally a hydrophobic chromatography step. Moving from batch to integrated separation minimizes hold‐up times, storage tanks, and required equip
We present a microscopic model for collective effects in high multiplicity proton–proton collisions, where multiple partonic subcollisions give rise to a dense system of strings. From lattice calculations we know that QCD strings are transversely extended, and we argue that this should result in a transverse pressure and expansion, similar to the flow in a deconfined plasma. The model is implement
The transfer-appropriate processing (TAP) account holds that episodic memory depends on the overlap between encoding and retrieval processing (e.g., perceptual or conceptual). In the current study, we employed multivariate pattern analysis (MVPA) of electroencephalography to examine the relevance of spontaneously engaged processing during encoding for later retrieval. Participants encoded word-picThe transfer-appropriate processing (TAP) account holds that episodic memory depends on the overlap between encoding and retrieval processing (e.g., perceptual or conceptual). In the current study, we employed multivariate pattern analysis (MVPA) of electroencephalography to examine the relevance of spontaneously engaged processing during encoding for later retrieval. Participants encoded word-pic
Self-Service Business Intelligence (SSBI) enables business users, such as executives, managers, analysts, and knowledge workers to build reports on a need-basis to support their decisions and actions toward business success. This suggests that business users are empowered not only to consume information but also to author it. Yet, research on SSBI is mainly concentrated at the industrial level, an
In the past couple of decades, major efforts were made to increase reliability of metabolic assessments by magnetic resonance methods. Magnetic resonance spectroscopy (MRS) has been valuable for providing in vivo evidence and investigating biomarkers in neuropsychiatric disorders, namely schizophrenia. Alterations of glutamate and glutamine levels in brains of schizophrenia patients relative to he
Previous research has established that when engaged in episodic memory retrieval, people frequently look at locations associated with the sought-after memory trace, even if those locations no longer contain any information. While it has been further demonstrated that gaze positions showing compatibility between encoding and retrieval increase the likelihood of successful remembering (Johansson &amPrevious research has established that when engaged in episodic memory retrieval, people frequently look at locations associated with the sought-after memory trace, even if those locations no longer contain any information. While it has been further demonstrated that gaze positions showing compatibility between encoding and retrieval increase the likelihood of successful remembering (Johansson &am
