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Epithelial to mesenchymal transition (EMT) of cancer cells involves loss of epithelial polarity and adhesiveness, and gain of invasive and migratory mesenchymal behaviours. EMT occurs in prostate cancer (PCa) but it is unknown whether this is in specific areas of primary tumours. We examined whether any of eleven EMT-related proteins have altered expression or subcellular localisation within the e

Hematopoietic stem cell (HSC) numbers are tightly regulated and maintained in postnatal hematopoiesis. Extensive studies have supported a role of the cytokine tyrosine kinase receptor Kit in sustaining cycling HSCs when competing with wild-type HSCs posttransplantation, but not in maintenance of quiescent HSCs in steady state adult bone marrow. In this study, we investigated HSC regulation in Whit

Popular Abstract in Swedish Den här avhandlingen behandlar modeller för studier av gnist-urladdningar i kemiskt icke-reagerande gaser. Modellerna är härledda från grundläggande principer inom ramen för kontinuums mekanik. De processer som sker under övergången från en gnista till en flamma kan delas upp i fysikaliska och kemiska processer. Denna studie är inriktad på de fysikaliska processerna. PlThis thesis pertains to the models for studying sparking in chemically inert gases. The models are derived from the basic principles and framework in continuum mechanics. The processes taking place in a spark to flame transition can be segregated into physical and chemical processes. This study is focused on physical processes. The plasma is regarded as a single-substance material. One and two-dim

The requirements on optical links for transferring analog and digital signals from the detector front-ends to the readout electronics at future high-luminosity colliders are reviewed. The advantages of external modulation techniques are discussed. An outline is given of the the R&D programme recently started at CERN by a collaboration involving high-energy physics institutes, optoelectronics r

224 patients with undisplaced femoral neck fractures treated with two parallel Hansson hook pins were studied. After a mean follow-up time of 32 months (S.D. 5.2), 15% had a reoperation. 11% were considered failures, mostly avascular necrosis, and 9% had a secondary arthroplasty. Possible risk factors for poor outcome were analysed. Neither high age nor surgical delay was associated with increased

OBJECTIVE: To investigate the association between marital status and daily smoking, adjusting for economic conditions and trust. STUDY DESIGN: Cross-sectional study. METHODS: In total, 27,757 individuals aged 18-80 years answered a postal questionnaire, which represents 59% of the random sample. A logistic regression model was used to investigate the association between marital status and daily sm

Background: Previous studies of differently charged polypeptides, Poly-L-lysine (PL) and Poly-L-Glutamate (PG) have shown promising results, reducing postoperative adhesions. This study aimed to investigate the possible anti adhesion effect of those combined polypeptides, after adhesiolys. The concentration of tPA, PAI-1 and active TGFb1 in biopsies from adhesions, unharmed peritoneum before and a

Aiming to start a constructive debate,“A tour to sustainability?” examines the preparedness of the tour operating sector to undertake the challenges of sustainable tourism. Drivers and barriers for acknowledging operators’ share of impacts and consequently their responsibilities for actions are presented and analysed further. The influential potential of tour operators in tourism industry is defin

This thesis investigates visual attention during decision-making in natural environments in four different studies. The first study demonstrated that decisions in the supermarket were suboptimal and this did not seem to relate to the amount of products attended to or the amount of time spent on each product. Consumers also failed to look at a subsection of products that better suited their prefe

This study aimed to investigate medical healthcare utilization 3-5 years following the decision about long-term care at home vs. in special accommodation in older people. A total of 1079 people who were granted long-term care the years 2001, 2002 or 2003 were studied regarding the number of hospital stays and the number of contacts with physicians in outpatient care in the 3-5 subsequent years. Th

Swedish Cystic Fibrosis (CF) care follows international guidelines in general. The only difference in our CF care package since 25 years is the physiotherapy regimen. Airway clearance therapy has since the early 1980s, from the day of diagnosis, been based upon daily physical exercise in conjunction with techniques for transporting and evacuating mucus. Postural Drainage+/-percussion and vibration