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There is an increasing amount of knowledge on the cytotoxic properties of cyanotoxins, but relatively little is known regarding their fine specificity and mechanisms of action. In this study, we investigated the influence of microcystin-LR and AnTx-a on mouse B- and T-lymphocyte subpopulations in vitro. Cyanotoxins significantly decreased the cell viability after 4 and 24 h, compared to the untrea
Popular Abstract in Swedish Alla levande organismer består av celler som tillsammans med molekyler generellt kallade extracellulär matrix bildar en vävnad. Celler innehåller fyra huvudgrupper av byggstenar: socker, fettsyror, aminosyror och nukleotider, vilka i tur och ordning bildar kolhydrater, fetter, proteiner och nukleinsyror. I vävnaderna pågår en ständig omsättning av byggstenarna och molekThis thesis describes structural and functional studies of alpha-1-microglobulin (a1m), a 26 kDa plasma and tissue protein that is evolutionarily well-conserved and belongs to the lipocalin superfamily. The lipocalins are polypeptides of 160-190-amino acids that are folded into an 8-stranded beta-barrel forming a pocket with a hydrophobic interior. a1m carries heterogeneous yellow-brown chromophor
The dependence of effective pair gap on weakly bound neutron orbits is studied in deformed nuclei in comparison with that in spherical nuclei, solving the Hartree-Fock-Bogoliubov equation in a simplified model in coordinate space with the correct asymptotic boundary conditions. In spherical nuclei the effective pair gap of s1/2 neutrons decreases to zero in the limit that the corresponding Hartree
In a regional population of 32,120 liveborn newborn infants 65 (0.2%) had a birthweight less than or equal to 900 g (extremely small low birthweight = ESLBW) with mean gestational age 26.4 (range 22-31) completed weeks of gestation. The total 0-1 year survival rate was 48%. For the 42 infants treated in the Level III regional neonatal intensive care unit (NICU) the 0-1 year survival rate was 55% v
The etiology of ethanol-associated osteopenia is not fully understood. A direct inhibitory effect of ethanol on osteoblast function has been suggested by in vitro and in vivo studies. In this study, we measured biochemical markers for bone formation (osteocalcin, bone specific alkaline phosphatase, procollagen-1-c-terminal peptide) and resorption (c-terminal telopeptide and urine deoxypyridinoline
Numerical simulations using Large Eddy Simulation (LES) are applied to turbulent swirling flow fields. The swirling motion is often introduced into combustors to act as flame holders or enhance the mixing between species. Different turbulence models capture the swirling motion more or less accurately. LES is well suited for understanding details of swirling flows. It resolves all the large scales
Presented are the first formal descriptions of mosasaur remains of Maastrichtian age from the Danish mainland (Jylland, Sjaelland); just two taxa are recognised, viz. Mosasaurus cf. hoffmanni and Plioplatecarpus sp. Recent finds include an association of skeletal fragments, inclusive of a single marginal tooth crown, from within 10 metres or so of the K/T boundary near Holtug, Stevns Klint (Sjaell
The Kalman-Yakubovich-Popov (KYP) lemma has been a cornerstone in system theory and network analysis and synthesis. It relates an analytic property of a square transfer matrix in the frequency domain to a set of algebraic equations involving parameters of a minimal realization in time domain. This note proves that the KYP lemma is also valid for realizations which are stabilizable and observable
The objective of this study is to contribute to the knowledge about the effects of foreign aid in Tanzania during the period 1964-93. However, such a study is also relevant from a more general perspective since the results can hopefully be relevant for other aid-recipient countries. Chapter 2 presents the size, forms, and allocation of the foreign aid inflow to Tanzania during the four aid regime
In current debate a number of terms are used to describe the positions of different groups and individuals, eg. deviation, marginalisation, segregation, integration, inclusion and exclusion. The terminology aids us in giving everyday life a manageable structure and meaning, but it also work as a tool of stigma and to keep large groups outside society, not least in research agendas. By using the te
Force and isotonic shortening velocities were studied (0.6-4.0 degreesC) in isolated single muscle spindles from the anterior tibialis muscle of Rana temporaria using techniques that enabled measurements both from the spindle as a whole and from marked segments of the preparation. The force-velocity relationship during tetanic stimulation exhibited the same biphasic shape as previously described f
The application of k(t)-factorization supplemented with the CCFM small-x evolution equation to heavy quark production is discussed. The b (b) over bar production cross sections at the TEVATRON can be consistently described using the k(t)-factorization formalism together with the unintegrated gluon density obtained within the CCFM evolution approach from a fit to HERA F-2 data. Special attention is
