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Specific inhibition of the entry of encephalitogenic T lymphocytes into the central nervous system in multiple sclerosis would provide a means of inhibiting disease without compromising innate immune responses. We show here that targeting lymphocyte interactions with endothelial basement membrane laminins provides such a possibility. In mouse experimental autoimmune encephalomyelitis, T lymphocyte

Popular Abstract in Swedish Avhandlingens ämne är monstrets roll i människans försök att definiera sig själv – hur kroppar som kan benämnas ”monstruösa” fungerar som naturfilosofiska figurer i humanismens strävan att avgränsa det mänskliga från det omänskliga. Studien spänner över perioden från renässansen eller den tidigmoderna eran till postmoderniteten men fokuserar den franska miljön och två gThis dissertation studies the problem of the inhuman in relation to human nature in philosophy from antiquity to the present, highlighting the interrelationship between science and philosophy in the development of concepts of monstrosity in France from mid-sixteenth century to late twentieth century thought. By means of constraint, it focuses on Ambroise Paré (1509/10–90) and Gilles Deleuze (1925–

Methods. A 3-month pharmacokinetic substudy of the prospective, randomized, multicentre, open-label Symphony study was performed. Eighty-three adult renal transplant patients received standard-dose cyclosporine, MMF 2 g/day and corticosteroids, or daclizumab induction, MMF 2 g/day and corticosteroids plus low-dose cyclosporine, low-dose tacrolimus or low-dose sirolimus. The area under the concentr

In order to study the ability of costimulation blockade to induce tolerance to human embryonic stem cells (HESC), severe combined immunodeficient (SCID), and immunocompetent C57BL/6 mice treated with costimulation blockade received intratesticular and intramyocardial HESC transplants. All SCID mice with intratesticular HESC transplants developed teratoma. When SCID mice were transplanted intramyoc

A soil disturbance experiment was performed during two seasons in degraded, calcareous sandy grassland in southern Sweden. pH, extractable phosphorus, plant species richness and vegetation composition were analyzed. Mechanical soil disturbance had no effect on pH, and caused only a minor increase in extractable phosphorus. Positive effects compared to control plots were seen on plot scale (360 m2)

Tracking human body motions using inertial sensors has become a well-accepted method in ambulatory applications since the subject is not confined to a lab-bounded volume. However, a major drawback is the inability to estimate relative body positions over time because inertial sensor information only allows position tracking through strapdown integration, but doesn't provide any information about r

A pair of rotational bands associated with the pi h(9/2) circle times nu i(13/2)(-1) configuration at lower spins and with the pi h(9/2) circle times nu i(13/2)(-3) configuration at higher spins is found in Tl-194. The two 4-quasiparticle bands show exceptionally close near-degeneracy in the excitation energies. Furthermore close similarity is also found in their alignments and B(M1)/B(E2) reduced

Recension av The Pathos of Authenticity. American Passions for the Real.

Receding glaciers are among the most obvious changes caused by global warming, and glacial meltwater entering lakes generally forms plumes of particles. By taking vertical samples along a horizontal gradient from such a particle source, we found that photosynthetically active radiation (PAR) and ultraviolet radiation (UVR) attenuated 20-25% faster close to the inflow of suspended particles compare

We present detailed observations of the bright short-hard gamma-ray burst GRB 090510 made with the Gammaray Burst Monitor (GBM) and Large Area Telescope (LAT) on board the Fermi observatory. GRB 090510 is the first burst detected by the LAT that shows strong evidence for a deviation from a Band spectral fitting function during the prompt emission phase. The time-integrated spectrum is fit by the s

Exkursionen till Skäckerfjäll 2010 led mot sitt slut, men ett av de finaste fynden skulle göras i elfte timmen. Ulf Arup berättar hur det gick till när det första fyndet i landet på 113 år av denna art gjordes.

Ultraviolet radiation (UVR) causes physical damage to DNA, carboxylation of proteins and peroxidation of lipids in copepod crustaceans, ubiquitous and abundant secondary producers in most aquatic ecosystems. Copepod adaptations for long duration exposures include changes in behaviour, changes in pigmentation and ultimately changes in morphology. Adaptations to short-term exposures are little studi

This thesis addresses what students describe as their reasons for attending university, their descriptions of their encounters with the university milieu, and what significance they believe the existence of a local university such as Halmstad in south-west Sweden may have had in this. The empirical basis of the study consists of interviews with 58 students taking one of three courses at Halmstad U

The far-infrared spectra of solid orthodeuterium and solid normal deuterium are presented and compared to the corresponding spectra of solid parahydrogen and solid normal hydrogen. Spectra of water in orthodeuterium are compared to spectra of water in parahydrogen. The water rotation constants in orthodeuterium are approximately 80% of the rotation constants of water in parahydrogen. The S(0)(0) b

The investigation of how exactly salespeople create value at the individual level of interaction is still incomplete. While there have been lively debates on value,creation and co-creation processes at the organizational level in the business marketing literature, researchers have paid much less attention to the fact that such processes almost always start at the interpersonal level of buyer-selle

Control of haemorrhage is vital in all operative settings. As complement to traditional surgical haemostatic techniques, a heterogeneous collection of absorbable substances with haemostatic capacity have been developed; topical haemostatic agents. The widespread variety of the products and the study-populations (clinical or experimental) make interpretation of previously performed studies difficul

A small number of proteins have the unusual property of tasting intensely sweet. Despite many studies aimed at identifying their sweet taste determinants, the molecular basis of protein sweetness is not fully understood. Recent mutational studies of monellin have implicated positively charged residues in sweetness. In the present work, the effect of overall net charge was investigated using the co

Assessment of the potential impact of climate change on water systems has been an essential part of hydrological research over the last couple of decades. However, the notion that such assessments should also include technological, demographic and land use changes is relatively recent. In this study, the potential impacts of climate change and continued urbanisation on waste and stormwater flows i