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Background: Ipilimumab, a monoclonal antibody against cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), was the first approved checkpoint inhibitor; however, its use is hampered by treatment-related adverse events (TRAEs). ATOR-1015 is a bispecific antibody targeting CTLA-4 and OX40 designed to direct the effect to the tumor microenvironment and thereby improve the response rate and reduce TRA
Context. The nuclear stellar disc (NSD) of the Milky Way is a dense, rotating stellar system in the central ~200 pc. The NSD is thought to be primarily fuelled by bar-driven gas inflows from the inner Galactic disc. Aims. As part of the LEGARE project, we aim to construct the first chemical-evolution models for the NSD using a Bayesian approach tailored to reproducing the observed metallicity-dist
The Common Agricultural Policy (CAP) has become one of the EUs most contested policy areas. But despite widely observed patterns of rural resentment and farmers’ resistance to environmental policies, few studies have examined the CAPs political consequences beyond recent farmers protests. Drawing on policy feedback theory, Bourdieu’s theory of symbolic fields, and scholarship on sociotechnical ima
The industrial sector, also called secondary sector, is in charge of transforming materials into goods. An important workforce is employed in the industrial sector not only in modern industrial countries, but in all modern societies. Since many of these jobs entail working under wet conditions, heat, or with hazardous chemicals, both irritant and allergic occupational contact dermatitis are of utm
Durable and high-performing anion-exchange membranes (AEMs) are key components in alkaline water electrolyzers and fuel cells. As potentially more sustainable and cost-effective alternatives to proton exchange membrane (PEM)-based systems, AEM-based devices can operate without platinum-group metal catalysts or perfluorinated polymers. However, their broader practical implementation remains limited
The study of fluid transport in porous media is crucial for many applications in science and engineering. From a modeling perspective, understanding how diffusion parameters behave when microstructural variations are taken into account is a significant step toward achieving more detailed and accurate model predictions. It is widely recognized that hydraulic tortuosity is typically approximated as
Optimization and electrical control of photovoltaic (PV) and proton exchange membrane (PEM) electrolyzer systems are critical for efficient, scalable hydrogen production. Static coupling methods employ fixed electrical interconnections between PV arrays and the PEM stack, which cannot adapt to fluctuating irradiance or temperature. To overcome this, we propose an adaptive reconfiguration optimizat
A fundamental aspect of describing vocal activity is to quantify its overall level. For instance, everyone agrees that animals become more vocal when they are excited or stressed, but what does it mean to be ‘more vocal’? Increased duration of individual calls and their repetition rate are the most commonly reported temporal markers of arousal, but proportion of time [spent] vocalising (PTV) appea
Corrosion of prestressing steel in post-tensioned (PT) cables is a critical issue in prestressed concrete bridges, often leading to brittle and unexpected failures. This deterioration is primarily attributed to construction flaws such as inadequate grout injection and the use of poor-quality mortar. This paper presents a probabilistic model for estimating the number and spatial distribution of gro
Inhibition of several of the 10 hallmarks of cancer (Hanahan and Weinberg) would result in a broader and more durable treatment compared to current single or combination drug treatments. Galectin-1 and galectin-3 have been proposed to together be involved in all 10 hallmarks, suggesting that development of a combined galectin-1/3 inhibitor would be beneficial. Specificity toward galectin-1 or -3 c
Att skapa fasta förbindelser mellan länder genom att bygga broar eller tunnlar är mycket kostsamt, men politiska beslutsfattare hoppas i allmänhet att dessa gigantiska infrastrukturprojekt ska öka internationella handelsflöden. Vi utnyttjar öppnandet av Öresundsbron för att testa om det stämmer. Vårt forskningsprojekt visar att Sverige och Danmark handlar ca 25 procent mer med varandra än man sku
Sustainability standards and ratings do not generate enough information for businesses to understand their environmental impacts across scales and create mitigation plans to avoid further transgression of planetary boundaries.
Among historians and archaeologists, the medieval towns of Roskilde and Lund have been perceived as almost twin towns. Both were founded in the late 10th century, with bishop’s seats established in the 11th century. Both quickly rose to become the most politically, economically, and culturally important ecclesiastical centres in southern Scandinavia, with similar urban landscapes dominated by nume
Objectives: To evaluate the impact of the 2018 switch from PCV13 to PCV10 in Sweden’s childhood immunisation programme on the serotype distribution of Streptococcus pneumoniae.MethodsRespiratory tract (RT) S. pneumoniae isolates (n=1615; 2020–2023) were serotyped, tested for antimicrobial susceptibility and compared with invasive pneumococcal disease (IPD) isolates (n=397) and PCV13-era data (2016
Electrostatic energy plays a pivotal role in the minimization of the free energy of self-assembling oppositely charged ions. This is a fundamental principle that guides the formation of aggregates and the separation of phases characterized by a stoichiometric balance between the opposite charges. However, this study unveils the self-assembly of catanionic nanotubes from a mixture of oppositely cha
