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Tissue factor pathway inhibitor-2 (TFPI-2) has previously been characterized as an endogenous anticoagulant. TFPI-2 is expressed in the vast majority of cells, mainly secreted into the extracellular matrix. Recently we reported that EDC34, a C-terminal peptide derived from TFPI-2, exerts a broad antimicrobial activity. In the present study, we describe a previously unknown antimicrobial mode of ac
A decision is the result of comparing one or more alternatives with respect to one or more criteria that we consider relevant to the decision. Decision making can be considered as one of the most important challenges that analysts and experts encounter to solve complex problems. In recent decades, different methods and algorithms have been presented to support decision making. Multi-criteria analy
Inula conyzae was discovered in Vellinge, southwestern Skåne in July 2007 Twenty-seven plants were found along a slope leading down to a small pond, and eight more individuals were discovered on a field nearby. The population seems to be several years old, and will hopefully expand. This is the first record of I. conyzae in Sweden since 1974. We discuss possible ways of immigration from neighbouri
I syfte att utvärdera effekten av dubbdäcksförbudet på Friggagatan med avseende på luftkvaliteten har Miljöförvaltningen i Göteborg på uppdrag av trafikkontoret i Göteborg utfört luftkvalitetsmätningar på Friggagatan mellan 2013-01-01 och 2013-09-30. Dessutom utförde Miljöförvaltningen mätningar av dubbdäcksanvändningen på Friggagatan, vid Drottningtorget och i Haga. Vidare användes även mätdata f
Background: Brain reserve is a concept introduced to explain why Alzheimer's disease (AD) patients with a greater brain volume prior to onset of pathology generally have better clinical outcomes. In this review, we provide a historical background of the emergence of brain reserve and discuss several aspects that need further clarification, including the dynamic or static nature of the concept and
Huntington disease (HD) is an autosomal dominant neurodegenerative disorder caused by expanded CAG repeats in the huntingtin gene (HTT). Although mutant HTT is expressed during embryonic development and throughout life, clinical HD usually manifests later in adulthood. A number of studies document neurodevelopmental changes associated with mutant HTT, but whether these are reversible under therapy
Billions of animals are adapted to a travelling life, making regular return migrations between more or less distant living stations on Earth by swimming, flying, running or walking (Figure 1). Extremely long migrations are completed annually by whales between calving areas in warmer waters and feeding areas at higher latitudes in either hemisphere. The longest oceanic migrations among sea turtles
The resilience of nationalism in contemporary Europe may seem paradoxical at a time when the nation state is widely seen as being 'in decline'. The contributors of this book see the resurgence of nationalism as symptomatic of the quest for identity and meaning in the complex modern world. Challenged from above by the supranational imperatives of globalism and from below by the complex pluralism of
One of the most important trends in contemporary tourism is the increase in urban tourism, both in absolute and in relative terms. An increasing number of cities have become significant tourism destinations. Cities also attract an increasingly diverse set of visitors, some of which could be called alternative tourists. The development of alternative tourism is related to decreasing relative costs One of the most important trends in contemporary tourism is the increase in urban tourism, both in absolute and in relative terms. An increasing number of cities have become significant tourism destinations. Cities also attract an increasingly diverse set of visitors, some of which could be called alternative tourists. The development of alternative tourism is related to decreasing relative costs
Continuously monitoring its position in space relative to a goal is one of the most essential tasks for an animal that moves through its environment. Species as diverse as rats, bees, and crabs achieve this by integrating all changes of direction with the distance covered during their foraging trips, a process called path integration. They generate an estimate of their current position relative to
What do a burly rower, a backstroke swimmer and a hard-working South African dung beetle all have in common? The answer is: they all benefit from moving along a straight path, and do so moving backwards. This, however, is where the similarity ends. While the rower has solved this navigational challenge by handing the task of steering to the coxswain, who faces the direction of travel, and the swim
A new method to improve the accuracy and efficiency of characteristic mode (CM) decomposition for perfectly conducting bodies is presented. The method uses the expansion of the Green dyadic in spherical vector waves. This expansion is utilized in the method of moments (MoM) solution of the electric field integral equation (EFIE) to factorize the real part of the impedance matrix. The factorization
