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Two central steps in the hydrolysis of lactam antibiotics catalyzed by mononuclear metallo--lactamases, formation of the tetrahedral intermediate and its breakdown by proton transfer, are studied for model systems using the density functional B3LYP method. Metallo--lactamases have two metal ion binding sites, one of which is occupied in the mononuclear species. In this work it is assumed that cata
The efficient in vitro inhibition of hepatitis B virus DNA polymerase by trisodium phosphonoformate (PFA, INN: foscarnet sodium) and its low toxicity suggested that PFA could be used as a therapeutic agent for hepatitis B infection. PFA was also found to inhibit woodchuck hepatitis virus (WHV) DNA polymerase in vitro. As a model to test PFA's eventual effect, chronically WHV infected woodchucks we
The helicity structure of the diffractive electroproduction of rho mesons, e + p --> e + rho + Y, is studied in a previously unexplored region of large four-momentum transfer squared at the proton vertex, t: 0 < t' < 3 GeV2, where t' = - min. The data used are collected with the HI detector at HERA in the kinematic domain 2.5 < Q(2) < 60 GeV2, 40 < W < 120 GeV No t dependence of the r(00)(04)
To mimic the electron-donor side of photosystem II (PSII), three trinuclear ruthenium complexes (2, 2 a, 2 b) were synthesized. In these complexes, a mixed-valent dinuclear moiety with one phenoxy and two acetato bridges is covalently linked to a RuII tris-bipyridine photosensitizer. The properties and photoinduced electron/energy transfer of these complexes were studied. The results show that the
This paper discusses the relation between verbal inflection and clausal structure, making the claim, based on evidence from Icelandic finite verb inflection, that formal verbal features, such as Number, Person, Tense and Mood, each represents (or corresponds to) a functional head in clausal structure. More generally, the paper claims that there is a one-to-one correspondance between formal feature
Objective: To explore the direct and Indirect costs in a cohort of 225 risperidone-treated patients with schizophrenia followed up annually during 5 years. Method: Data on costs for medication, hospitalization, sheltered living and productivity losses, as well as degree of social isolation, were collected. Results: The direct costs were dominated by hospitalization and sheltered living expenses, w
Purpose: To examine retinal function in a patient with decreased vision possibly due to treatment with methotrexate. Methods: Ophthalmological examination included testing of visual acuity (VA), fundus inspection, fundus photography and kinetic perimetry. Retinal function was tested objectively with three electrophysiological methods: full-field electroretinography (ERG), multifocal electroretino
Bode's sensitivity integral is a well-known formula that quantifies some of the limitations in feedback control for linear time-invariant systems. In this note, we show that there is a similar formula for linear time-periodic systems. The harmonic transfer function is used to prove the result. We use the notion of roll-off 2, which means that the first time-varying Markov parameter is equal to zer
