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Despite extensive insights into the underlying genetics and biology of acute myeloid leukemia (AML), overall survival remains poor and new therapies are needed. We found that casein kinase 1 alpha (Csnk1a1), a serine-threonine kinase, is essential for AML cell survival in vivo. Normal hematopoietic stem and progenitor cells (HSPCs) were relatively less affected by shRNA-mediated knockdown of Csnk1
P-wave morphology reflects the projection of the depolarization vector on the electrocardiogram (ECG)lead axes in three-dimentional space and reflects both right and left atrial activation. The main purpose of current thesis was to explore the internal logic between the atrial conduction properties, including intra- and inter- atrial conduction, and P-wave characteristics from the level of histolo
To compare the cancer risk of cladribine and other disease-modifying drugs (DMDs) in trials of people with relapsing multiple sclerosis (pwRMS).
Two searches for supersymmetric particles in final states containing a same-flavour opposite-sign lepton pair, jets and large missing transverse momentum are presented. The proton-proton collision data used in these searches were collected at a centre-of-mass energy root s = 8TeV by the ATLAS detector at the Large Hadron Collider and corresponds to an integrated luminosity of 20.3 fb(-1). Two lept
We demonstrate experimentally and numerically that an x-ray prism made of beryllium can be used to disperse and monochromatize x-rays. A polished beryllium cuboid was employed as refractive and dispersive optics. The results of a proof-of-principle experiment and methods of performance optimization are presented. The spatial separation of undulator harmonics and their subsequent selection using a
Background: Marsupial syndactyly is a curious morphology of the foot found in all species of diprotodontian and peramelemorph marsupials. It is traditionally defined as a condition in which digits II and III of the foot are bound by skin and are reduced. Past treatments of marsupial syndactyly have not considered the implications of this unique morphology for broader issues of digit development an
This review summarises the evidence for the treatment of displaced fractures of the femoral neck in elderly patients. Results from randomised clinical trials and national register studies are presented when available. The advantages of arthroplasty compared with internal fixation are supported by several studies. A number of studies contribute to the discussions of total hip arthroplasty (THA) ver
Background. In SBRT of lung tumours no established relationship between dose-volume parameters and the incidence of lung toxicity is found. The aim of this study is to compare the LQ model and the universal survival curve (USC) to calculate biologically equivalent doses in SBRT to see if this will improve knowledge on this relationship. Material and methods. Toxicity data on radiation pneumonitis
The Soil Conservation Service Curve Number (SCS-CN) method developed by the USDA-Soil Conservation Service (SCS, 1972) is widely used for the estimation of direct runoff for a given rainfall event from small agricultural watersheds. The initial soil moisture plays an important role in re-structuring of the SCS-CN method and enables us to prevent unreasonable sudden jump in runoff estimation and th
Context. High-precision astrometric and radial-velocity observations require accurate modelling of stellar motions in order to extrapolate measurements over long time intervals, and to detect deviations from uniform motion caused, for example, by unseen companions. Aims. We aim to explore the simplest possible kinematic model of stellar motions, namely that of uniform rectilinear motion relative t
Heat transfer and flow characteristics of six ribbed channels of square cross section having different rib structure are computed with the objective of improving heat transfer in the lee-side of the ribs. Six ribs are installed on the bottom walls of each channel. The rib pitch-to-height ratio (P/e) is 10. Details of the turbulent flow structure, temperature fields, local heat transfer coefficient
We present the findings of our phenomenological interview study concerning the meaning of being an autonomous person while dependent on advanced medical technology at home. This was elucidated in the participants' narratives as befriending everyday life when bringing technology into the private sphere. We discovered four constituents of the phenomenon: befriending the lived body, depending on good
Suboptimal listening conditions interfere with listeners' on-line comprehension. A degraded source signal, noise that interferes with sound transmission, and/or listeners' cognitive or linguistic limitations are examples of adverse listening conditions. Few studies have explored the interaction of these factors in pediatric populations. Yet, they represent an increasing challenge in educational se
Pollination contributes to an estimated one third of global food production, through both the improvement of the yield and the quality of crops. Volatile compounds emitted by crop flowers mediate plant-pollinator interactions, but differences between crop varieties are still little explored. We investigated whether the visitation of crop flowers is determined by variety-specific flower volatiles u
Background/Aims: Thrombocytes have proved to be important for liver regeneration after liver resection in the experimental setting. The aim of our study is to examine the effects of thrombocytes on liver hypertrophy after portal vein embolization (PVE). Methodology: This retrospective cohort study comprised 75 patients with liver metastases from colorectal cancer subjected to PVE in preparation fo
The ALICE experiment will start recording data in 2008. The capabilities of the ALICE experiment for measuring anisotropic flow have been investigated using simulations. The results are discussed both for elliptic flow in a wide rapidity region using different detector sub-systems and for directed flow using the zero degree calorimeter. Feasibility of measuring any anisotropic emission of J/ψ is a
