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This narrative review describes a new approach to navigation in a challenging landscape of clinical drug development in diabetes. Successful outcome studies in recent years have led to new indications and guidelines in type 2 diabetes, yet the number of clinical trials in diabetes is now declining. This is due to many environmental factors acting in concert, including the prioritisation of funding
Background: Short-term trials conducted in adults with type 2 diabetes mellitus (T2DM) showed that reducing sedentary behaviour by performing regular short bouts of light-intensity physical activity enhances health. Moreover, support for reducing sedentary behaviour may be provided at a low cost via mobile health technology (mHealth). There are a wide range of mHealth solutions available including
Background: Patient-reported outcome measures (PROMs) are frequently used to assess the effects of treatments in patients with wrist osteoarthritis (OA), but their psychometric properties have not been evaluated in this group of patients. Our aim was to evaluate the psychometric properties of the Numeric Rating Scale (NRS pain at rest, pain on motion without load, and pain on load), the Disabiliti
Mixing process is crucial for ignition and combustion in powder-fueled ramjets. The mixing performance depends mainly on the inlet layout. In this study, the effects of four popular inlet layouts were investigated and were found to significantly influence the particle distribution. In this study, the Savitzky-Golay approach was used to handle large amounts of data on particles to obtain clear peak
With the increasing demand for natural gas and depletion of many sweet gas fields, direct usage of sour gas, usually containing a large percentage of hydrogen sulfide (H2S), becomes a more economical choice in recent years. However, the laminar burning velocity (SL) of CH4+H2S flames have seldom been investigated due to the corrosivity and toxicity of H2S, and no available experimental data can be
Background: Persons with bipolar disorder (BD) have a higher cardiovascular mortality compared to the general population, partially explained by the increased burden of cardiovascular risk factors. Research regarding outcomes following acute coronary syndrome (ACS) in this population remains scarce. Design: This Danish register-based study included patients diagnosed with BD and ACS in the period
A major radiological or nuclear emergency may, apart from causing a substantial loss of life and physical damage, also put a substantial strain on affected societies with social, economic and political consequences. Although such emergencies are relatively uncommon, it is now being increasingly recognised that their subsequent psychosocial impact can be widespread and long lasting. Mental health e
A division of labor with role specialization is defined as individuals specializing in a subtask during repetitions of a group task. While this behavior is ubiquitous among humans, there are only four candidates found among non-eusocial mammals: lions, mice, chimpanzees, and bottlenose dolphins. Bottlenose dolphins in the Cedar Keys, Florida, engage in role specialized “driver-barrier feeding”, wh
In the sense of phenomenology, actions are special cases of acts of consciousness. Within semiotics, first Jan Mukařovský and then A. J. Greimas have established, in different terms, a distinction between instrumental actions and actions which carry their meaning in themselves. But this is insufficient to account for the variety of actions which comprises everything from the creation of artefacts,
Fetal growth restriction (FGR) in human pregnancy is associated with perinatal mortality, short- and long-term morbidities. No prenatal therapy is currently established despite decades of research. We aimed to review interventions in animal models for prenatal FGR treatment, and to seek the next steps for an effective clinical therapy. We registered our protocol and searched MEDLINE, Embase, and T
Introduction: Current drug treatment of lower urinary tract disorders, for example, overactive bladder syndrome and lower urinary tract symptoms associated with benign prostatic hyperplasia, is moderately effective, has a low treatment persistence and some short- and long-term adverse events. Even if combination therapy with approved drugs may offer advantages in some patients, there is still a ne
The present edited research aims to capture a bird’s-eye view of the phenomenon of illicit trafficking of cultural properties and to serve as a reference point for governments, enforcement agencies, international organizations, stakeholders, and civil societies. The targeted geographic region is the Arab World, the countries in the Middle East, Arabic Gulf, Horn of Africa and North Africa. There i
This study explored the relationship between the glucose dose and insulin response from beta cells in vivo and in vitro in mice. Glucose was administered intravenously at different dose levels (from 0 to 0.75 g/kg) in anesthetized C57BL/6J mice, and the glucose and insulin concentrations were determined in samples taken after 50 min. Furthermore, freshly isolated mouse islets were incubated for 60
Cian Duffy’s chapter is concerned with the Danish poet and dramatist Adam Oehlenschläger, often identified as Denmark’s leading Romantic-period writer. Duffy focuses on an early instance of Oehlenschläger’s reception in England: an essay on contemporary German drama by Julius Charles Hare in the first and only number of Charles Ollier’s Literary Miscellany. Drawing also on theories about the relat
The archaeological site of Heraqla in Raqqa represents a particular example of the Abbasid architecture; the Caliph Harun Al Rashid started reconstructing it as a commemorative monument but after his death it was never completed. The Directorate General of Antiquities and Museums DGAM excavated in the site, constructed furnace to produce bricks similar to the ancient material for restorations and,
Our knowledge regarding the migration of the Homo erectus towards Eurasia and the routes he took through the Middle East during the Paleolithic is limited. The latest surveys and excavations at sites in the central Syrian Desert have revealed important data on these routes. Archaeological labor documented numerous archaeological sites located between the Mount Bishri and the Middle Euphrates Valle
Domain decomposition is one of the most efficient techniques to derive efficient methods for large-scale problems. In this chapter such decomposition methods for the minimization of the total variation are discussed. We differ between approaches which directly tackle the (primal) total variation minimization and approaches which deal with their predual formulation. Thereby we mainly concentrate on
ABSTRACT: Radiation dosimetry is central to virtually all radiation safety applications, optimization, and research. It relates to various individuals and population groups and to miscellaneous exposure situations-including planned, existing, and emergency situations. The International Commission on Radiological Protection (ICRP) has developed a new computational framework for internal dose estima
Hannah Persson’s essay looks at the early reception in England of Denmark’s most famous writer Hans Christian Andersen, showing how Andersen was (mis)represented in England as a result of the particular inflection given to his work by his translator, Mary Howitt. Examining Howitt’s praxis as a translator, Persson concludes that her (mis)understanding of Andersen’s tales as primarily intended for c
