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Dissemination of Bacillus anthracis from the respiratory mucosa is a critical step in the establishment of inhalational anthrax. Recent in vitro and in vivo studies indicated that this organism was able to penetrate the lung epithelium by directly entering into epithelial cells of the lung; however the molecular details of B. anthracis breaching the epithelium were lacking. Here, using a combinati

Heparan sulfate (HS) interacts with a variety of proteins and thus mediates numerous complex biological processes. These interactions critically depend on the patterns of O-sulfate groups within the HS chains that determine binding sites for proteins. In particular the distribution of 6-O-sulfated glucosamine residues influences binding and activity of HS-dependent signaling molecules. The protein

Heparan sulfate mediates numerous complex biological processes. Its action critically depends on the amount and the positions of O-sulfate groups (iduronyl 2-O-sulfates, glucosaminyl 6-O- and 3-O-sulfates) that form binding sites for proteins. The structures and distribution of these protein-binding domains are influenced by the expression and substrate specificity of heparan sulfate biosynthetic

Glycosaminoglycan heparan sulphate interacts with a variety of proteins, such as growth factors, cytokines, enzymes and inhibitors and, thus, influences cellular functions, including adhesion, motility, differentiation and morphogenesis. The interactions generally involve saccharide domains in heparan sulphate chains, with precisely located O-sulphate groups. The 6-O-sulphate groups on glucosamine

Introduction Episodic memory allows us to revisit our past and recollect inter-related elements that characterize life events (Tulving, 1983). When forming such relational memories, we only apprehend a small part of our visual field in full acuity at a time. This limitation is overcome by shifting visual attention over a sequence of eye movements. We bind these visual “samples” of the world into

Prevotella copri DSM18205T is a human gut bacterium, suggested as a next-generation probiotic. To utilize it as such, it is, however, necessary to grow the species in a reproducible manner. Prevotella copri has previously been reported to be highly sensitive to oxygen, and hence difficult to isolate and cultivate. This study presents successful batch cultivation strategies for viable strain inocul

Prevotella copri is a bacterium that can be found in the human gastrointestinal tract (GIT). The role of P. copri in the GIT is unclear, and elevated numbers of the microbe have been reported both in dietary fiber-induced improvement in glucose metabolism but also in conjunction with certain inflammatory conditions. These findings raised our interest in investigating the possibility of P. copri to

The Virus-X-Viral Metagenomics for Innovation Value-project was a scientific expedition to explore and exploit uncharted territory of genetic diversity in extreme natural environments such as geothermal hot springs and deep-sea ocean ecosystems. Specifically, the project was set to analyse and exploit viral metagenomes with the ultimate goal of developing new gene products with high innovation val

A literature review of methods where different hazards are combined into a multi-hazard index or method are presented in this report. The purpose of the review is to get an insight into approaches to combine different hazards into a multi-hazard index or method.To directly combine hazards, it is necessary to present them with the same unit of measure. This can be done with different measures for nA literature review of methods where different hazards are combined into a multi-hazard index or method are presented in this report. The purpose of the review is to get an insight into approaches to combine different hazards into a multi-hazard index or method. To directly combine hazards, it is necessary to present them with the same unit of measure. This can be done with different measures for

North Sámi has a class of derived verbs called sensive verbs. Descriptively, these verbs are formed by adding the suffix /ʃ/ to an adjectival or nominal base, and the resulting verb means ‘find [object] (too) ADJECTIVE/NOUN’. In this paper it is argued that the sensive verbs do not involve any psychological verb, and the suffix is not specified as “sensive” in the lexicon. Rather, the suffix is spNorth Sámi has a class of derived verbs called sensive verbs. Descriptively, these verbs are formed by adding the suffix /ʃ/ to an adjectival or nominal base, and the resulting verb means ‘find [object] (too) ADJECTIVE/NOUN’. In this paper it is argued that the sensive verbs do not involve any psychological verb, and the suffix is not specified as “sensive” in the lexicon. Rather, the suffix is sp

Få, om noen, kan gjøre Jomfru Maria rangen stridig som mest betydningsfull kvinneskikkelse i den kristne verden – iallfall slik religionen ser ut i dag. Blant katolikker og ortodokse er hun gjenstand for en nesten bunnløs folkelig hengivenhet, og mange protestanter nærer dyp kjærlighet til og respekt for henne. Også muslimer verden over oppfatter Jesu mor som et forbilde og søker blant annet henne

Severe COVID-19 can result in pneumonia and acute respiratory failure. Accumulation of mucus in the airways is a hall mark of the disease and can result in hypoxemia. Here, we show that quantitative proteome analysis of the sputum from severe COVID-19 patients reveal high levels of neutrophil extracellular trap(s) (NETs) components, which was confirmed by microscopy. Extracellular DNA from excessi

Understanding how maritime hunter-gatherer diets changed through time in response to increasing social complexity can help us understand important transitions in early human history. This paper presents new baseline stable isotope values for southern California with an emphasis on marine plant and animal species. We use our baseline database to reevaluate human stable isotope values from the regio

Numbers are used for exact and approximative estimations. The numbers used in approximative expressions are typically so-called round numbers, such as 10, 20, 25, 30, 40, 50, 100, 1,000, and such numbers are also very frequent in texts. This article presents evidence that some numbers are rounder than others and discusses how the roundness of a number can be derived from its contents of the base n