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Retinitis pigmentosa (RP) defines a group of inherited degenerative retinal diseases causing progressive loss of photoreceptors. To this day, RP is still untreatable and rational treatment development will require a thorough understanding of the underlying cell death mechanisms. Methylation of the DNA base cytosine by DNA methyltransferases (DNMTs) is an important epigenetic factor regulating gene
Musculoskeletal disorders (MSD) account for the majority of total morbidity cases in the working-age Swedish population. These disorders are thought to be the reason given for one-third of total certified sick leave requests. In addition to the high cost to society, MSD involve both physical and emotional suffering, pain and financial and social problems for the injured persons. The aim of this st
In this article I discuss the Nordic province of Bohuslan in the decade after it became 'Swedish' in 1658, at the stage I describe as the province's 'transitional period'. The aim of the study is to show how the traditional understanding of what happens when national borders are redrawn needs to be understood in the light of the nature of the early modern state. Records from the district court of
A real-time pattern recognition algorithm based on k-nearest neighbors and lazy learning was used to classify, voluntary electromyography (EMG) signals and to simultaneously control movements of a dexterous artificial hand. EMG signals were superficially recorded by eight pairs of electrodes from the stumps of five transradial amputees and forearms of five able-bodied participants and used online
Popular Abstract in Swedish Nygjuten betong innehåller överskottsfukt som avges till omgivningen under uttorkningen. Om uttorkningen får fortsätta i en konstant luftfuktighet antar betongen så småningom samma fuktighet. Eftersom betong är ett tätt material tar det lång tid, ofta flera år, innan så har skett. Tills detta har inträffat sker en fukttransport från de inre delarna ut till ytan. En delThere were two principal objectives for this thesis. The first was to develop a methodology and evaluation model of moisture redistribution in order to make the future relative humidity in a screeded concrete slab predictable. The second objective was to develop a method to determine the critical humidity for ion transport in concrete. Residual moisture in screeded concrete slabs may be redistrib
Jämförelse av filmerna Robocop från 1987 och 2014 och på vilka sätt som respektive samtid speglas i dem.
Migration is commonly associated with large scale movements of people, from one country to another, both in terms of refugee displacement and voluntary migration. The internal movement within countries is however less studied despite the fact that this is an important indicator for imbalance and also crucial for planning the future for the country. In Iraq, a major reason for migration has been se
Background: Aquaporins, also called major intrinsic proteins (MIPs), constitute an ancient superfamily of channel proteins that facilitate the transport of water and small solutes across cell membranes. MIPs are found in almost all living organisms and are particularly abundant in plants where they form a divergent group of proteins able to transport a wide selection of substrates. Results: Analys
In our contemporary age, the name praise song has got a special meaning, roughly defined as: a song consisting of a rather short text that is sung over and over again, set to music in some contemporary popular style, directed by a worship leader, and accompanied by a team with instruments that may be unusual in church, as el-guitars and drums. The phenomenon is described and critically evaluated.
Ship-generated waves were investigated in the Gota alv river, which is a major waterway on the Swedish west coast between the sea and Lake Vanern. Ships with a typical size of 85x15x5 m (lengthxwidthxdraft) travel at speeds between 5 and 10 knots, generating waves that cause sediment transport and erosion along the river bed and banks. Field measurements of the wave properties and turbidity were c
Highly skilled workers are increasingly recognised as a key competitive asset for regional development, and claims have been made that emphasise the importance of certain amenities for the prospects of attracting this particular group of workers. We use a recent large-scale survey to investigate the relative importance of jobs versus amenities for the decision to migrate, as perceived by the migra
The ubiquitin-editing enzyme A20 (TNFAIP3) and the deubiquitinase CYLD are central negative regulators of NF-kappa B signaling. Both can act by removing nonproteolytic K63-linked polyubiquitin chains from an overlapping set of signaling molecules. In B cells, A20 deficiency results in hyperactivity, loss of immune homeostasis, inflammation, and autoimmunity. The reported consequences of CYLD defic
The production of isolated photons in deep-inelastic scattering ep -> e gamma X is measured with the H1 detector at HERA. The measurement is performed in the kinematic range of negative four-momentum transfer squared 4 < Q(2)< 150 GeV2 and a mass of the hadronic system W-X > 50 GeV. The analysis is based on a total integrated luminosity of 227 pb(-1). The production cross section of isolated photo
The ability to entrap drugs within vehicles and subsequently release them has led to new treatments for a number of diseases. Based on an associative phase separation and interfacial diffusion approach, we developed a way to prepare DNA gel particles without adding any kind of cross-linker or organic solvent. Among the various agents studied, cationic surfactants offered particularly efficient con
Solljus, sand av mineralen kvarts eller fältspat samt naturligt förekommande radioaktivitet är förutsättningarna för att kunna använda så kallad luminiscensdatering. Metoden används för att åldersbestämma geologiska händelser under den senaste istiden och har bidragit till en ny syn på nedisningarna i Skandinavien.
We investigate optimal maneuvers for vehicles on different road surfaces such as asphalt, snow, and ice. This study is motivated by the desire to find control strategies for improved future vehicle safety and driver assistance technologies. Based on earlier presented empirical measurements for tire-force characteristics, we develop vehicle and tire models corresponding to different road conditions
My PhD submission is made up of a constellation of three elements that form a body of textual material / theory and practice event / exhibition. (1) A dimension of critical writing or dissertation that has two parts: (a) Retrospective / Prospective: Activating the Archive, September 1, 2010, and (b) an accretion of further analysis, Archive, Archived, Archiving, September 1, 2011. (2) A testin
