The present thesis is devoted to two different matters: One part is the development of a novel optical technique for characterisation of solid pharmaceutical materials. The other part being the continued development of photon time-of-flight spectroscopy, as well as exploration of new application areas of this method. These two optical techniques are conceptually and technically very different, but

Introduction: Development of industrial yeast strains with high tolerance towards the inhibitors released during biomass pretreatment is critical for bioethanol production. Combining this trait with increased thermotolerance would result in a more efficient production via Simultaneous Saccharification and Fermentation (SSF) as well as reduced cooling costs. The aim of the present work was to devel

Leukocyte recruitment is known to be a key feature at sites of inflammation and important in the combat against infectious agents. However, the mechanisms of leukocyte recruitment in the pulmonary microvasculature in response to local and systemic inflammation remain elusive. Abdominal sepsis is associated with significant changes in systemic inflammation and coagulation. We hypothesized that leuk

Angular correlations between unidentified charged trigger (t) and associated (a) particles are measured by the ALICE experiment in Pb-Pb collisions at root s(NN) = 2.76 TeV for transverse momenta 0.25 < p(T)(t,a) < 15 GeV/c, where p(T)(t) > p(T)(a). The shapes of the pair correlation distributions are studied in a variety of collision centrality classes between 0 and 50% of the total hadronic cros

ICA - instrumentation, control and automation - is a hidden technology. It is ubiquitous in all industrial processes, including water and wastewater treatment systems. Still, as long as everything works fine, it is not noted but when things go wrong it will be observed. ICA has now about forty years of history in water and wastewater systems and is well recognized. One early attitude was that ICA

Purpose: To investigate the use of different modes of transport and long-term changes among stroke survivors with cognitive functional limitations (CFLs), and to study differences among sub-groups (decreased/ceased vs. unchanged and increased public transport use) regarding physical functional limitations (PFLs), CFLs, depression, and social activity outside home. Method: Survey of 79 individuals

In this paper we analyze the convergence properties of full discretizations of a class of generalized porous medium equations. For the spatial and time discretizations, we use continuous piecewise linear finite elements and algebraically stable Runge-Kutta methods, respectively. We prove our convergence result without any assumption on the spatial regularity. It is shown that, under a certain stab

The purpose of this study was to develop techniques to quantify the propagation pattern of the electrical activation during atrial fibrillation (AF) along a one-dimensional catheter. Taking intra-atrial signal organization aspects into account, the atrial activations are detected and combined into wavefronts. Parameters describing wavefront consistency and activation order along the catheter are d

Nanoclusters containing metallic lead and lead oxide have been produced by self-assembly out of a primary mixture of lead atoms and oxygen in a reactive sputtering-based cluster source. Comparison of the valence and core-level responses in the photoelectron spectra shows that clusters have a core-shell structure with a lead-oxide core coated by an outer shell of metallic lead. This core-shell orde

Contraceptive drugs are nowadays found in aquatic environments around the globe. Particularly, 17 alpha-ethinylestradiol (EE2) may act even at low concentrations, such as those recorded in natural ecosystems. We evaluated the physiological effects of EE2 on cyclopoids and calanoids, common copepods in both marine and freshwater communities. We used three EE2 concentrations and assessed its impact

Popular Abstract in Swedish Varför lade människor ner stenar, ben och redskap i vatten och våtmarker under förhistorisk tid? Och hur kan arkeologin skapa förståelse för denna typ av lämningar? Vanligen tolkas de nedlagda föremålen som offer, men det är ett begrepp som är förknippat med en rad problem. Bland annat riskerar användningen av offerbegreppet att dölja olikheter och nyanser i människornaThis thesis deals with questions concerning theoretical perspectives and archaeological interpretation. It is also a thesis about prehistoric wetland depositions, as they illustrate the discussion. The starting point of the study is the use of the concept of sacrifice (or offering) in Scandinavian archaeology. There are several assumptions, both explicit and implicit, that are considered problemat

3,4-Dihydroxyphenyl-l-alanine (l-DOPA)-induced dyskinesia often develops as a side effect of chronic l-DOPA therapy. This study was undertaken to investigate dopamine (DA) release upon l-DOPA treatment. Chronoamperometric measurements were performed in unilaterally DA-depleted rats, chronically treated with l-DOPA, resulting in dyskinetic and non-dyskinetic animals. Normal and lesioned l-DOPA naiv

Recension av Dennis E. Showalter & Harold C. Deutsch (red.); Om Tyskland segrat – 53 alternativa scenarier.

Background: Derivatized celluloses, such as methylcellulose (MC) and hydroxypropyl methylcellulose (HPMC), are of pharmaceutical importance and extensively employed in tablet matrices. Each batch of derivatized cellulose is thoroughly characterized before utilized in tablet formulations as batch-to-batch differences can affect drug release. The substitution pattern of the derivatized cellulose pol

The health impact of dietary replacement of carbohydrates with protein for patients with type 2 diabetes is still debated. This study aimed to investigate the association between dietary substitution of carbohydrates with (animal and plant) protein and 5-year weight change, and all-cause and cardiovascular (CVD) mortality risk in patients with type 2 diabetes.

Cholesterol lowering statins have been demonstrated to exert anti-tumoral effects on breast cancer by decreasing proliferation as measured by Ki67. The biological mechanisms behind the anti-proliferative effects remain elusive. The aim of this study was to investigate potential statin-induced effects on the central cell cycle regulators cyclin D1 and p27.