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Background and Purpose: Malignant melanoma is the most lethal form of skin cancer, characterised by a poor survival rate. One of the key factors driving the aggressive growth of melanoma cells is the elevated expression of the proto-oncogene Bcl-3. This study aims to optimise, evaluate and characterise a second-generation Bcl-3 inhibitor, using melanoma as a model to demonstrate its potential ther
Introduction: Attention-deficit/hyperactivity disorder (ADHD) frequently exists alongside psychiatric comorbidities. The coexistence of somatic diseases and ADHD constitutes a growing field of research. Method: This study aimed to examine the prevalence of common somatic diseases in adolescents with ADHD and compare them with those in adolescents without any psychiatric diagnoses. A cross-sectiona
Background: Psychiatric disorders have been associated with venous thromboembolism (VTE). However, to our knowledge, no nationwide study has examined the familial association between VTE and psychiatric disorders. Objectives: We took a pedigree-based approach and examined the risk of psychiatric disorders in offspring from extended pedigrees according to the densities of VTE in pedigrees. Methods:
Lipid nanoparticles (LNPs) are clinically approved for mRNA-based vaccines and liver-targeted siRNA delivery. However, poor nucleic acid delivery efficiency limits their application in extrahepatic tissues and tumors. Here, using live-cell and super-resolution microscopy, we identify multiple distinct steps of inefficiencies in the cytosolic delivery of both siRNA and mRNA cargoes. Membrane damage
This article probes the writings of the Jewish Trotskyist thinker Daniel Bensaïd (1946–2010) in light of recent debates on political theology. In contrast to what is sometimes explicitly referred to as ‘apocalyptic political theology’, it makes a case for what may be described as a ‘prophetic political theology’. Yet it is not obvious to claim Bensaïd as a proponent for such a project, since he ex
Global change is altering forests worldwide, with multiple consequences for ecosystem functioning. Temporal changes in climate, and extreme, compounded weather events like hotter droughts are affecting the demography, composition and function of forests, leading to a highly uncertain future. To accurately predict future forest responses to hotter droughts, we highlight the need for considering a b
Utvärderingen visar att ersättningar för att sköta betesmarker och slåtterängar har en positiv men begränsad effekt på biologisk mångfald i form av fågelfauna och en sammansatt landskapsindikator. Andra stöd och ersättningar som utvärderades har mindre betydelse för dessa indikatorer. Utvärderingen poängterar dock behovet av förbättrad övervakning och data som möjliggör mer detaljerade utvärderingWe have evaluated the impact of the Rural Development Programme 2014–2022 and its support of measures benefitting biodiversity. Bird population sizes, using the Farmland Bird Index (FBI), serve as the main indicator of biodiversity, but the High Nature Value Farmland (HNV) indicator is also used. Our conclusions are:• A combination of approaches is required to evaluate the effects of agrienvironme
