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Background: In patients with rectal cancer, when it is not possible to restore bowel continuity with an anastomosis, the optimal surgical method is still a matter of debate. The aim of this trial was to determine 30-day postoperative surgical complication rates after Hartmann’s procedure (HP) versus intersphincteric abdominoperineal excision (iAPE) in patients with rectal cancer who were not suita

We investigate the young stellar cluster population of M51 and how it is affected by encounters with giant molecular clouds (GMCs). We combine a galactic model with N-body simulations of 5000 unique clusters in the mass range [600-24000] M⊙. We simulate each cluster twice: with (CR) and without (CN) tidal perturbations from the GMCs. We are able to reproduce the majority of the observed mass- and

The end of what the GDR called “real existierender Sozialismus” in Europe at the beginning of the 1990s dramatically changed the geopolitical situation in Central and Eastern Europe. Five states ceased to exist, whereas 22 new states have been recognized, accompanied by a host of internationally unrecognized states. Nearly half a century of relative stability in Europe was replaced by volatility a

Adaptive dynamical networks (ADNs) describe systems in which the states of the network nodes and the network structure itself co-evolve over time. This interplay of two coupled dynamical processes underlies a wide range of natural and technological phenomena, such as neural plasticity, learning, and opinion formation. The inherently co-evolutionary nature of ADNs poses significant challenges to ma

Allergic asthma is characterized by Type 2 inflammation and eosinophilia. Tartrate-resistant acid phosphatase 5 (TRAP5; also referred to as acid phosphatase 5 [ACP5]) is a metallophosphatase expressed by alveolar macrophages that dephosphorylates osteopontin, a phosphoglycoprotein with increased expression in asthma. To investigate the role of TRAP5 during asthma, we used a murine model of ovalbum

Objective: To investigate the development of sexual activity, sexual function, and body image in women with primary vulvar cancer from the time of diagnosis to 24 months after the end of treatment. Methods: This nationwide prospective cohort study assessed health-related quality of life in women with newly diagnosed vulvar cancer using validated patient-reported outcome measures (EORTC-QLQ-VU34 [E

OBJECTIVE: To estimate the prevalence and predictors of sustained remission (SR) in patients with psoriatic arthritis (PsA) receiving biologic or targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs) in Sweden. METHODS: All patients with PsA initiating b/tsDMARDs and who were registered in the national Swedish Rheumatology Quality Register (SRQ) from April 1999 to December 2019 wer

Using an Earth-abundant transition metal to mediate formation and splitting of C-C σ-bonds, in response to electrical stimuli, constitutes a promising strategy to construct complex organic skeletons. Here, we showcase how [nBu4N][N3] reacts with an isocyanide adduct of a tetrahedral and high-spin TiII complex, [(TptBu,Me)TiCl] (1), to enact N-atom transfer, C-N bond formation, and C-C coupling, to

ObjectivesThis nested case–control study aimed to investigate the relationship between components of the Swedish food-based dietary guidelines (SDG) from 2015 and the risk of developing rheumatoid arthritis (RA).MethodsData were obtained from the prospective Malmö Diet and Cancer Study (MDCS) conducted 1991–1996. Diet was assessed at baseline using a validated diet history method. Incident RA case

Subdural hemorrhage, retinal hemorrhages, and encephalopathy are associated with the medical diagnosis of abusive head trauma. These findings have also been observed in children exposed to admitted or witnessed shaking. There are various suggested mechanisms behind these findings. One mechanism is exclusive to intentional shaking, while the other suggested mechanisms are compatible with both inten

BACKGROUND: Sharp force injuries display varying patterns depending on the manner of death (homicide, suicide, accidental). The purpose of this study was to analyse forensic autopsy data to examine the characteristics of sharp force injuries on the extremities, to differentiate between different manners of death and to examine demographic differences.METHODS: This retrospective cohort study utiliz

This thesis presents four interconnected studies showing methods for characterizing and separating cells based on their acoustic properties, with particular focus on isolating rare cells from blood samples.The first study introduces a technique for single-cell density measurements using microcapillary-adapted density gradient centrifugation. Using fluorescent markers to visualize the density gradi

This thesis examines the Climate Mass held in Stockholm Cathedral in September 2023. The aim is to understand the theology of the Climate Mass and how it terms and theologically processes and interpret the climate crisis in a Swedish church sermon. The thesis also investigates how the context matter for theology in eco-theological preaching in the Church of Sweden. Using an eco-theological framewo

Claims to 'crisis' reverberate across societal and academic discourses, as people around the world face dire situations and detrimental challenges. Yet, the study of crisis tends to remain siloed and therefore oblivious to the multi-dimensional nature of crisis, which inhibits learning from one type of crisis to the next. Bringing together a broad team of contributors, this book argues for a new i

The global aviation industry is experiencing growing pressure to decarbonize, driving significant demand for Sustainable Aviation Fuel (SAF). Second-generation feedstocks that do not directly compete with food crops, such as lipid oils from insects and lignin-derived oils, are promising sources, but their high concentrations of inorganic contaminants and oxygen make them incompatible with existing

Machine Learning (ML) offers many opportunities, but its reliance on personal data raises privacy concerns. One such example is the Membership Inference Attack (MIA), which aims to determine whether a specific data point was part of a model’s training dataset. In this paper, we investigate this attack on Random Forests (RFs) and propose a method to quantify their vulnerability to MIA. We also demo

Speech signal decoding relies on both cognitive performance and the ability to perceive the acoustic signal in sufficient detail. In everyday communication, natural speech is often rapid, spatially and spectrally complex, and accompanied by noise. The brain generates predictions to cope with the complex nature of the auditory signal in speech perception. Anticipatory coarticulation is a natural pa