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Homofoba uttalanden i radio kan vara diskriminering i arbetslivet
Anställningsavtal kan delas upp på flera förvärvare vid verksamhetsövergång
Inte nödvändigt att bussarna överlåts för att det ska vara verksamhetsövergång vid entreprenörsbyte
EU-domstolen: Cykelbud var inte arbetstagare
The ILO Response to Covid-19: ILO and International Labour Standards in Times of a Pandemic
α-Hemolysin of uropathogenic E. coli regulates NLRP3 inflammasome activation and mitochondrial dysfunction in THP-1 macrophages
Hemolysin expressing UPEC strains have been associated with severe advanced kidney pathologies, such as cystitis and pyelonephritis, which are associated with an inflammatory response. Macrophages play an important role in regulating an inflammatory response during a urinary tract infection. We have studied the role of purified recombinant α-hemolysin in inducing inflammatory responses and cell de
Validation of a stroke model in rat compatible with rt-PA-induced thrombolysis : new hope for successful translation to the clinic
The recent clinical trial (DAWN) suggests that recanalization treatment may be beneficial up to 24 h after stroke onset, thus re-opening avenues for development of new therapeutic strategies. Unfortunately, there is a continuous failure of drugs in clinical trials and one of the major reasons proposed for this translational roadblock is the animal models. Therefore, the purpose of this study was t
Numerical investigation of flow field and heat transfer characteristics in a latticework duct with jet cooling structures
Interaction effects of the latticework duct and jet cooling structures on the flow structure and heat transfer were numerically investigated. The latticework duct included eleven sub-channels both on the top wall and bottom wall. The crossing angle was set as 90°. The jet cooling structures had a curved target surface and seven jet nozzles. The jet cooling structures and latticework duct were conn
Design of safety education activities for safety-critical facilities
Mendelian randomization implies no direct causal association between leukocyte telomere length and amyotrophic lateral sclerosis
We employed Mendelian randomization (MR) to evaluate the causal relationship between leukocyte telomere length (LTL) and amyotrophic lateral sclerosis (ALS) with summary statistics from genome-wide association studies (n = ~ 38,000 for LTL and ~ 81,000 for ALS in the European population; n = ~ 23,000 for LTL and ~ 4,100 for ALS in the Asian population). We further evaluated mediation roles of lipi
Human TRPA1 is an inherently mechanosensitive bilayer-gated ion channel
The role of mammalian Transient Receptor Potential Ankyrin 1 (TRPA1) as a mechanosensor is controversial. Here, we report that purified human TRPA1 (hTRPA1) with and without its N-terminal ankyrin repeat domain responded with pressure-dependent single-channel current activity when reconstituted into artificial lipid bilayers. The hTRPA1 activity was abolished by the thiol reducing agent TCEP. Thus
Individual Driving Behaviour in Wildfire Smoke
This work presents the results of a virtual reality (VR) experiment aiming at investigating how individual driving behaviour is affected by the presence of wildfire smoke. The experiment included a driving simulation task to study the chosen driving speed at different smoke densities and the lateral position of the driven car on the road cross section. During the VR experiment, participants were p
The making of green steel in the EU : a policy evaluation for the early commercialization phase
In the attempt to reduce greenhouse gas emissions from steel production, several large industry decarbonization projects have emerged in Europe. The commercialization of low-emission steel technology, however, faces systemic barriers such as a lack of infrastructure and unclear demand for greener steel. As part of its new commitment to climate-neutrality, the European Commission has announced plan
Direct and indirect selection on mate choice during pollen competition : Effects of male and female sexual traits on offspring performance following two-donor crosses
Mate choice in plants is poorly understood, in particular its indirect genetic benefits, but also the direct benefits of avoiding harmful matings. In the herb Collinsia heterophylla, delayed stigma receptivity has been suggested to enhance pollen competition, potentially functioning as a female mate choice trait. Previous studies show that this trait can mitigate the cost of early fertilization ca
Discriminative Accuracy of Plasma Phospho-tau217 for Alzheimer Disease vs Other Neurodegenerative Disorders
Importance: There are limitations in current diagnostic testing approaches for Alzheimer disease (AD). Objective: To examine plasma tau phosphorylated at threonine 217 (P-tau217) as a diagnostic biomarker for AD. Design, Setting, and Participants: Three cross-sectional cohorts: an Arizona-based neuropathology cohort (cohort 1), including 34 participants with AD and 47 without AD (dates of enrollme
A Brief Breathing Space : Experiences of Brief Admission by Self-Referral for Self-Harming and Suicidal Individuals with a History of Extensive Psychiatric Inpatient Care
Individuals with severe self-harm and experiences of lengthy psychiatric admissions often have complex mental health conditions and are at risk of suicide. In this qualitative study, self-harming individuals with >180 days of psychiatric admission over 12 months shared their experiences of Brief Admission (BA), a standardized crisis-management intervention encouraging self-admission and autonomy.
What to share, when, and where : balancing the objectives and complexities of open source software contributions
Context:: Software-intensive organizations’ rationale for sharing Open Source Software (OSS) may be driven by both idealistic, strategic and commercial objectives, and include both monetary as well as non-monetary benefits. To gain the potential benefits, an organization may need to consider what they share and how, while taking into account risks, costs and other complexities. Objective:: This st
Tinted, Detached, and Lazy CNF-XOR Solving and Its Applications to Counting and Sampling
Given a Boolean formula, the problem of counting seeks to estimate the number of solutions of F while the problem of uniform sampling seeks to sample solutions uniformly at random. Counting and uniform sampling are fundamental problems in computer science with a wide range of applications ranging from constrained random simulation, probabilistic inference to network reliability and beyond. The pas
The effect of hydration status on plasma FGF21 concentrations in humans: A subanalysis of a randomised crossover trial
AIM: Fibroblast growth factor 21 (FGF21) has recently been implicated in thirst in rodent models. The mechanisms for this are currently uncertain, and it is unclear whether hydration status can alter FGF21 concentrations, potentially providing an additional mechanism by which hypohydration induces thirst. The aim of this study is therefore to understand whether hydration status can alter circulati