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T cells, B cells, and PD-L1 expression in esophageal and gastric adenocarcinoma before and after neoadjuvant chemotherapy : relationship with histopathological response and survival
Perioperative chemotherapy enhances the survival rates for patients with esophageal and gastric (EG) adenocarcinoma, but not all patients benefit from this additional treatment. Chemotherapeutic agents have been demonstrated to alter the immune cell (IC) composition in the tumor microenvironment. Hence, there is a rationale to investigate the influence of neoadjuvant chemotherapy (NAC) on differen
Increased inflammatory response in cytomegalovirus seropositive patients with Alzheimer's disease
Alzheimer's disease (AD) has been associated with increased local inflammation in the affected brain regions, and in some studies also with elevated levels of proinflammatory cytokines in peripheral blood. Cytomegalovirus (CMV) is known to promote a more effector-oriented phenotype in the T-cell compartment, increasing with age. The aim of this study was to investigate the inflammatory response of
Properties and emission factors of cloud condensation nuclei from biomass cookstoves - Observations of a strong dependency on potassium content in the fuel
Residential biomass combustion is a significant source of aerosol particles on regional and global scales influencing climate and human health. The main objective of the current study was to investigate the properties of cloud condensation nuclei (CCN) emitted from biomass burning of solid fuels in different cookstoves mostly of relevance to sub- Saharan east Africa. The traditional three-stone fi
Sibling rank and sibling number in relation to cardiovascular disease and mortality risk : A nationwide cohort study
Background The number and rank order of siblings could be of importance for risk of cardiovascular disease and mortality. Previous studies have used only fatal events for risk prediction. We, therefore, aimed to use also non-fatal coronary and cardiovascular events in fully adjusted models. Methods From the Multiple-Generation Register in Sweden, data were used from 1.36 million men and 1.32 milli
Dietary intake and plasma phospholipid concentrations of saturated, monounsaturated and trans fatty acids and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort
Epidemiologic studies examining the association between specific fatty acids and colorectal cancer (CRC) risk are inconclusive. We investigated the association between dietary estimates and plasma levels of individual and total saturated (SFA), monounsaturated (MUFA), industrial-processed trans (iTFA), and ruminant-sourced trans (rTFA) fatty acids, and CRC risk in the European Prospective Investig
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World Trade Organization
Surrounding the establishment of the World Trade Organization (WTO) in 1994, scholars discussed whether the new organization would contribute to a shift of global environmental governance toward more market-based mechanisms. According to the most favored nation clause, a WTO party has to grant any trade advantage it concedes to any one country to all other parties. The WTO treaties also include cl
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Improving disaster response evaluations : Supporting advances in disaster risk management through the enhancement of response evaluation usefulness
Future disasters or crises are difficult to predict and therefore hard to prepare for. However, while a specific event might not have happened, it can be simulated in an exercise. The evaluation of performance during such an exercise can provide important information regarding the current state of preparedness, and used to improve the response to future events. For this to happen, evaluation produ
Development and validation of a new clinical decision support tool to optimize screening for retinopathy of prematurity
Background/Aims Prematurely born infants undergo costly, stressful eye examinations to uncover the small fraction with retinopathy of prematurity (ROP) that needs treatment to prevent blindness. The aim was to develop a prediction tool (DIGIROP-Screen) with 100% sensitivity and high specificity to safely reduce screening of those infants not needing treatment. DIGIROP-Screen was compared with four
Grinding or shaving?-performance based economic decision support in the manufacturing of gears
This paper describes a case study at an automotive company with the purpose of developing an economically based decision support tool, for strategic decision about whether to chose grinding or shaving as a finishing method in gear manufacturing. In the study different cost models are compared regarding input parameters in alignment with the required input data required to make a decision. With the
Breast softness in patients randomised to postmastectomy breast reconstruction with an expander prosthesis or DIEP flap
Background Objectively measured breast softness in reconstructed breasts and its relation to patients’ subjective satisfactionwith breast softness has not yet been investigated. The aim of this study was to evaluate breast softness in patients 1 yearfollowing delayed breast reconstruction with an expander prosthesis (EP) or deep inferior epigastric perforator (DIEP) fap,using objective and subject
Demonstrating trustworthiness when collecting and sharing genomic data : public views across 22 countries
Background: Public trust is central to the collection of genomic and health data and the sustainability of genomic research. To merit trust, those involved in collecting and sharing data need to demonstrate they are trustworthy. However, it is unclear what measures are most likely to demonstrate this. Methods: We analyse the ‘Your DNA, Your Say’ online survey of public perspectives on genomic data
Platelets instruct T reg cells and macrophages in the resolution of lung inflammation
Intimate partner violence and the Nordic paradox
Survey data (FRA 2014) suggest that the lifetime rates of intimate partner violence against women (IPVAW) in the Nordic countries are among the highest in the EU, even though these countries are positioned as among the most gender equal in the world. This co-existence of high levels of gender equality and of high IPVAW rates, which has been termed the Nordic Paradox, has hitherto not been adequate
Professionals’ views on the relatively low prevalence of intimate partner violence against women in Spain
Variation in human milk composition is related to differences in milk and infant fecal microbial communities
Previously published data from our group and others demonstrate that human milk oligosaccharide (HMOs), as well as milk and infant fecal microbial profiles, vary by geography. However, little is known about the geographical variation of other milk-borne factors, such as lactose and protein, as well as the associations among these factors and microbial community structures in milk and infant feces.
Empowering Surgeons, Anesthesiologists, and Obstetricians to Incorporate Environmental Sustainability in the Operating Room
OBJECTIVE: We review the existing research on environmentally sustainable surgical practices to enable SAO to advocate for improved environmental sustainability in operating rooms across the country. SUMMARY OF BACKGROUND DATA: Climate change refers to the impact of greenhouse gases emitted as a byproduct of human activities, trapped within our atmosphere and resulting in hotter and more variable
Applied cultural analysis : Ethnography as compositional practice
Folke sits on a two-meter-high chair in the corner of a Norwegian man’s kitchen, observing, taking notes, and drawing up diagrams. Both he and the man he studies have been given clear instructions: the observer must be allowed to come and go as he pleases, must not be spoken to, and must never be included in the daily chores or routines of the people he is supposed to be studying. But things don’t
