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Quality of life (QoL) assessment in children with coagulation disorders is a relatively unstudied area. While hemophilia-specific questionnaires (such as Haemo-QoL) are available, no instrument for children with idiopathic thrombocytopenic purpura (ITP) has been validated yet. A disease-specific questionnaire for children with ITP was therefore developed (ITP-QoL) in three phases: (a) a preparator

Motivation: To develop tools for the submission of mutations to databases and maintenance of locus-specific mutation databases. Advanced, integrated computer systems are needed to store and organize the increasing mutation information. Results: The MUTbase program suite provides an easy, interactive and quality-controlled submission of information to mutation databases. For further study of the da

PURPOSE. To elucidate mechanisms behind the morphology of Thygeson's superficial punctate keratitis (TSPK). METHODS. Sixteen patients were examined with the slit lamp and photographed by non-contact photomicrography. The results were compared with morphology of epithelial keratitis in herpes simplex type 1 (HSV1), varicella zoster (VZV), and adenovirus type 8 (Ad8) infections, all previously studi

The effect of three different nitrogen sources on the growth of external ectomycorrhizal mycelium was studied in Perspex micorocosms. Nonsterile peat was used as substrate. Five different fungal isolates growing in symbiosis with pine seedlings were investigated: two isolates of Paxillus involutus, one of Suillus bovinus and two unidentified ectomycorrhizal fungi isolated from ectomycorrhizal root

Pain is a complex subjective experience with sensory-discriminative, emotional-affective and cognitive-evaluative components. Postoperative pain is associated with considerable psychological and physiological distress that may impede postoperative recovery and lead to increased morbidity and development of persistent post-surgical pain. There seems to be a considerable individual variability in po

Because of the extreme ecological and environmental changes along an urban-rural gradient, it has been proposed that urbanised and non-urbanised populations of the same species may be distinctly isolated. There is evidence that urban populations have become significantly different from the original forest populations in several aspects. However, little is known about the extent to which urban and

We present a measurement technique for quantifying coupling between semiconductor quantum dots in an array. This technique employs magnetoconductance fluctuations to probe the decrease in the average spacing of the quantum energy levels as the electron wave functions in the dots undergo hybridization. Focusing on Ga0.25In0.75As dots, we investigate hybridization as the coupling strength is varied

BACKGROUND: Signal transducer and activator of transcription 3 (Stat3) is constitutively active (phosphorylated) in several forms of cancer, including prostate cancer (PCa). Stat3 signaling may be an interesting target for cancer therapy since inhibition of this pathway mediates growth inhibition and apoptosis of these cells. In this study we investigated the in vitro and in vivo effects of the fu

The hypotheses of this investigation were based on conceiving of facial mimicry reactions in face-to-face interactions as an early automatic component in the process of emotional empathy. Differences between individuals high and low in emotional empathy were investigated. The parameters compared were facial mimicry reactions, as represented by electromyographic (EMG) activity, when individuals wer

Structure and health effects of inulin-type fructans have been extensively studied, while less is known about the properties of the graminan-type fructans in wheat. Arabinoxylan (AX) is another important indigestible component in cereal grains, which may have beneficial health effects. In this study, the fructan content in milling fractions of two wheat cultivars was determined and related to ash,

Mice were subjected to gastrectomy (GX) or sham operation (controls). Four to six weeks later the pancreatic islets were isolated and analysed for cAMP or alternatively incubated in a Krebs-Ringer based medium in an effort to study insulin secretion and cAMP accumulation in response to glucose or the adenylate cyclase activator forskolin. Freshly isolated islets from GX mice had higher cAMP conten

We describe the synthesis and antibacterial properties of a novel antimicrobial peptidyl derivative, (2S)-2-(Nalpha-benzyloxycarbonyl-arginyl-leucylamido-1-[(E)-cinnamoylamido]-3-methylbutane, structurally based upon the inhibitory centre of the human cysteine protease inhibitor, cystatin C. The derivative, here called Cystapep 1, displayed antibacterial activity against several clinically importa

Background: Moderately displaced two-fragment fractures of the radial head have been treated predominantly nonoperatively. Recently, however, open reduction and internal fixation has gradually gained interest, without clear evidence that initial nonoperative treatment leads to an unfavorable outcome. As a consequence, the purpose of the present study was to evaluate the long-term outcome after the

We report here a systematic, quantitative population analysis of transcription factor expression within developmental progenitors, made possible by a microfluidic chip-based "digital RT-PCR" assay that can count template molecules in cDNA samples prepared from single cells. In a survey encompassing five classes of early hematopoietic precursor, we found markedly heterogeneous expression of the tra

This was a cross-sectional study investigating factors related to satisfaction with care among long-term mentally ill patients diagnosed with schizophrenia, selected from an outpatient register. Demographic factors, personality variables, and health-related factors were related to their satisfaction with care. Satisfaction with care showed no relationships to demographic factors such as age, livin

Isolated skeletal elements of three hesperornithiform taxa are recorded from marine strata of latest early Campanian (sensu germanico) age in the Kristianstad Basin, southern Sweden. The material comprises Hesperornis rossicus Nessov and Yarkov, one of the largest Mesozoic aquatic birds known to date, Hesperornis sp. and Baptornis sp. The holotype (a dorsal vertebra) of Parascaniornis stensioei La

Nine hundred and eighty-four breast cancer patients were interviewed regarding exogenous hormonal use. This represents a random sample of breast cancer patients in Southern Sweden referred to the Department of Oncology at Lund for treatment between 1978 and 1997 (excluding 1980 and 1981) with a 100% follow-up. Ever-use of hormone replacement therapy (HRT) prior to diagnosis was significantly assoc