Induction of broadly neutralizing antibodies, such as the monoclonal antibodies IgGb12, 2F5 and 2G12, is the objective of most antibody-based HIV-1 vaccine undertakings. However, despite the relative conserved nature of epitopes targeted by these antibodies, mechanisms underlying the sensitivity of circulating HIV-1 variants to broadly neutralizing antibodies are not fully understood. Here we have

By analysing N2 mice from a cross between the inbred C57BL strain B10.Q and the NMRI-related NFR/N strain, we recently identified a quantitative trait locus (QTL) influencing litter size. This locus is now denoted Fecq4, and it is present on the murine chromosome 9. In the present paper, we describe how the Fecq4 fragment originating form the NFR/N mouse strain will affect B10.Q mice by means of b

Granulocyte chemotactic protein 2 (GCP-2)/CXCL6 is a CXC chemokine expressed by macrophages and epithelial and mesenchymal cells during inflammation. Through binding and activation of its receptors (CXCR1 and CXCR2), it exerts neutrophil-activating and angiogenic activities. Here we show that GCP-2/CXCL6 itself is antibacterial. Antibacterial activity against gram-positive and gram-negative pathog

En av vintergatans största stjärnor uppvisar ett märkligt beteende. Om ett år sker nästa utbrott.

Popular Abstract in Swedish Ämnet för avhandlingen är verbets morfologiska och stilistiska variation i den grekiska versromanen Erotokritos, ett av de främsta exemplen på den kretensiska renässansdiktningen. Undersökningen utgår från de i dikten förekommande verbformernas morfologiska variation, både vad avser stammar, ändelser och augment. Undersökningen koncentreras på de imperfektiva verbformerThe aim of the present study is to examine the polytypia (morphological variation) and semantic differentiations of the verb in Vitsentzos Kornaros' Erotokritos, to understand how these shape poetic style. We examine the stems and the endings in the imperfective active forms. Moreover, we investigate the augmented forms because at an early stage we found that Kornaros employs a degree of poetic li

The performance of LNAs and VCOs is of large importance to the complete wireless communications system. To achieve sufficient performance in microwave applications, LNAs and VCOs have therefore up to now mostly been manufactured in advanced and expensive semiconductor technologies. In this thesis it is shown, however, that by using a standard CMOS technology, combined with different packaging and

One complication in implant dentistry is the implant periapical lesion-IPL--which is a lesion around the apex of a stable implant diagnosed radiographically as a radioluscency in the bone at the apical part of an implant.The IPL can perform with or without clinical symptoms such as tenderness, swelling, suppuration and fistulation. This report describes 4 cases of IPL which were treated surgically

Kraven på mera avancerade verifieringsmetoder har ökat i takt med att det traditionella sättet att projektera en byggnads brandskydd har förändrats, samt att vi idag är mer medvetna om vilka riskerna är, t ex att tillförlitlighet i tekniska skyddssystem måste beaktas. Detta är nödvändigt för att säkerställa att samhällets krav på brandsäkerhet efterlevs och uppfylls.

Kallikrein 1 (KLK1), a key component of the kallikrein-kinin system, originates from a locus on the long arm of chromosome 19 that contains several related serine endopeptidases. The biological role of these kallikrein-related peptidases is not clear, but emerging evidence suggests that they might be important in several physiological systems, e.g., in male reproduction, skin homeostasis, tooth en

BACKGROUND: Limb development and patterning originate from a complex interplay between the skeletal elements, tendons, and muscles of the limb. One of the genes involved in patterning of limb muscles is the homeobox transcription factor Pitx2 but its role in forelimb development is uncharacterized. Pitx2 is expressed in the majority of premature presumptive forelimb musculature at embryonic day 12