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Galiellalactone (GL) is a fungal metabolite that presents antitumor activities on prostate cancer in vitro and in vivo. In this study we show that GL induced cell cycle arrest in G2/M phase, caspase-dependent apoptosis and also affected the microtubule organization and migration ability in DU145 cells. GL did not induce double strand DNA break but activated the ATR and ATM-mediated DNA damage resp

Context. The unusual Mira variable R Hya is well known for its declining period between AD 1770 and 1950, which is possibly attributed to a recent thermal pulse. Aims. The goal of this study is to probe the circumstellar envelope (CSE) around R Hya and to check for a correlation between the derived density structure and the declining period. Methods. We investigate the CSE around R Hya by performi

OBJECTIVE-The Type 1 Diabetes Genetics Consortium has collected type 1 diabetic families worldwide for genetic analysis. The major genetic determinants of type 1 diabetes are alleles at the HLA-DRB1 and DQB1 loci, with both susceptible and protective DR-DQ haplotypes present in all human populations. The aim of this study is to estimate the risk conferred by specific DR-DQ haplotypes and genotypes

A major challenge with single-nucleotide polymorphism (SNP) fingerprinting of bacteria and higher organisms is the combination of genome-wide screenings with the potential of multiplexing and accurate SNP detection. Single-nucleotide extension by the minisequencing principle represents a technology that both is highly accurate and enables multiplexing. A current bottleneck for direct genome analys

Objectives: The association between primary hyperparathyroidism (PHPT) and cardiovascular disease is incompletely understood. The aims of this study were to evaluate how cardiac function and markers of inflammation and endothelial dysfunction correlate in patients with mild PHPT, and how these markers are influenced by surgical cure of the parathyroid disease (PTX). Material and methods: Forty-fiv

Aluminium-based adjuvants (ABA) are the predominant adjuvants used in human vaccinations. While a consensus is yet to be reached on the aetiology of the biological activities of ABA several studies have identified shape, crystallinity and size as critical factors affecting their adjuvanticity. In spite of recent advances, the fate of ABA following their administration remains unclear. Few if any s

Experimental results for pointing tasks using a tongue control system are reported in this paper. Ten untrained subjects participated in the experiment. Both typing and pointing tasks were performed, in three short-term training sessions, in consecutive days, by each subject. The system provided a key pad (14 sensors) and a mouse pad (10 sensors with joystick functionality) whose placements were i

Background: There is compelling evidence showing that achieving good glycaemic control reduces the risk of microvascular complications in people with type 1 and type 2 diabetes. Likewise, there is clear evidence to show that achieving good glycaemic control reduces the risk of macrovascular complications in type 1 diabetes. The UKPDS 10-year follow up suggests that good glycaemic control also redu

A functionally normal TP53 is essential to protect organisms from developing cancer. Somatic mutations in the gene represent one of the highest recurring perturbations in human tumours, including colorectal cancer (CRC). However, the variegated phenotype of wide spectrum of somatic mutations in TP53 and the complexity of the disease prevent a straight interpretation of the mutational analysis in t

Airborne pollen has been associated with allergic symptoms in sensitized individuals, whereas atmospheric pollution indisputably aggravates the impact on the overall quality of life. Therefore, it is of major importance to correlate, forecast and disseminate information concerning high concentration levels of allergic pollen types and air pollutants to the public, in order to safeguard the quality

Popular Abstract in Danish Fysioterapi er en social og etisk praksis som udfolder sig under specifikke historiske, politiske, socialkulturelle og økonomiske forhold. Dansk fysioterapi i en privat kontekst er praktiseret, administreret og håndteret indenfor en neoliberal ideologi, der genererer udfordringer for både fysioterapeuter og borgere: Det forventes implicit at begge parter understøtter denPhysiotherapy is a social and ethical practice which unfolds under specific historical, political, socio-cultural and economic circumstances. Danish physiotherapy in a private context is practiced, administered and managed within a neoliberal ideology which generates challenges for both physiotherapists and their patients. This thesis aims to explore how physiotherapy in a Danish private context s

It is over three decades since a large terrestrial carbon sink (S-T) was first reported. The magnitude of the net sink is now relatively well known, and its importance for dampening atmospheric CO2 accumulation, and hence climate change, widely recognised. But the contributions of underlying processes are not well defined, particularly the role of emissions from land-use change (E-LUC) versus the

Objective. The association between smoking and idiopathic inflammatory bowel disease is well known; smoking seems to have a diverse effect. Crohn's disease is associated with smoking, while ulcerative colitis is associated with non-smoking. Data on smoking in microscopic colitis of the collagenous type (CC) are lacking. The aim of this investigation was to study smoking habits in CC and to observe

We have investigated multiphoton multiple ionization of argon and xenon atoms at 5 keV using a new x-ray free electron laser (XFEL) facility, the SPring-8 Angstrom Compact free electron LAser (SACLA) in Japan. The experimental results are compared with the new theoretical results presented here. The absolute fluence of the XFEL pulse has been determined with the help of the calculations utilizing

I klinisk praxis görs palpation per rektum rutinmässigt på vuxna patienter vid akut buk. Vi utvärderade evidensen för detta genom en systematisk litteratursökning och identifierade 16 relevanta originalstudier. Dessa visade att det saknas evidens för diagnostisk nytta av rektalpalpation vid akut buk, inklusive misstänkt appendicit. Rutinmässig rektalpalpation bör inte göras vid akut buk hos vuxnaA digital rectal examination (DRE) is standard practice in cases of acute abdomen in adult patients. We analyzed the evidence for this by a systematic literature search, and identified 16 relevant original studies. These studies showed that there is no evidence for a diagnostic value of DRE in adult patients with acute abdomen. We should stop doing routine DRE in adult cases of acute abdomen.

A large part of new pharmaceutical substances are characterized by a poor solubility and high hydrophobicity, which might lead to a difference in drug adsorption between fasted and fed patients. We have previously evaluated the release of hydrophobic drugs from tablets based on Pemulen TR2 and showed that the release can be manipulated by adding surfactants. Here we further evaluate the possibilit

Abstract in UndeterminedThe aim of this study was to evaluate the extent to which water use efficiency (WUE) at leaf scale can be used to assess WUE at canopy scale, leaf WUE being assumed to be a constant function of vapor pressure deficit and to thus not be dependent upon other environmental factors or varying leaf properties. Leaf WUE and its variability and dependencies were assessed using lea

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Free space optics is an interesting alternative for telemetry with medical implants, due to the high data bandwidths available at optical frequencies. Especially implanted brain-computer interfaces gives rise to large data sets that needs to be transmitted transcutaneous. In this paper we show that it is possible to establish such a link at near-IR wavelengths using a modulated reflector in the im