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Methodological point on mediation analysis

Recently, King et al.1 assessed the effect of disability on mental health through bullying in adolescents using a causal mediation analysis method developed by Valeri and VanderWeele2 in which exposure–mediator interactions are allowed. In the latter method, one can only handle time-fixed exposure and mediator, and, for this reason, the authors only used the exposure in wave 5 and mediator (and ou

https://www.lupop.lu.se/article/methodological-point-mediation-analysis - 2025-08-25

Using registries for research in CF. How can we be sure about the outputs?

In healthcare, we have kept notes on people with diseases for over 4000 years. These have been a combination of subjective commentary and objective measurement. In the past 30 years recording data on patients has been systematised through disease registries and electronic patient records (EPR). We now have extensive registries in many diseases with robust cross-sectional and more importantly, long

https://www.lupop.lu.se/article/using-registries-research-cf-how-can-we-be-sure-about-outputs - 2025-08-25

Nytt avtal med Elsevier

Bibsamkonsortiet tecknar ett läs- och publiceringsavtal med det vetenskapliga förlaget Elsevier. Det innebär att svenska forskare nu åter får tillgång till förlagets drygt två tusen tidskrifter. Dessutom kommer alla svenska forskningsartiklar kunna publiceras omedelbart öppet tillgängligt (open access). Läs mer här.

https://www.lupop.lu.se/article/nytt-avtal-med-elsevier - 2025-08-25

FORMAS urgent grants

Today, FORMAS announced the urgent grants for 2018 Last day of application: Any time during the year, until 08/11/2018Day of decision: Continuously during the year, last day of decision is 15/01/2019An urgent grant application can be submitted for any scientific discipline; the humanities, natural sciences, social sciences and technological sciences, and may also include interdisciplinary approach

https://www.lupop.lu.se/article/formas-urgent-grants - 2025-08-25

Characterizing Short-Term Jobs in a Population-Based Study

Work histories generally cover all jobs held for ≥1 year. However, it may be time and cost prohibitive to conduct a detailed exposure assessment for each such job. While disregarding short-term jobs can reduce the assessment burden, this can be problematic if those jobs contribute important exposure information towards understanding disease aetiology. New publication in Annals of work exposure and

https://www.lupop.lu.se/article/characterizing-short-term-jobs-population-based-study - 2025-08-25

For a sound use of health care data in epidemiology: evaluation of a calibration model for count data with application to prediction of cancer incidence in areas without cancer registry

There is a growing interest in using health care (HC) data to produce epidemiological surveillance indicators such as incidence. Typically, in the field of cancer, incidence is provided by local cancer registries which, in many countries, do not cover the whole territory; using proxy measures from available nationwide HC databases would appear to be a suitable approach to fill this gap. However, i

https://www.lupop.lu.se/article/sound-use-health-care-data-epidemiology-evaluation-calibration-model-count-data-application - 2025-08-25

Compared with whom? Reference groups in socio-economic comparisons and self-reported health in 34 countries

The association between socio-economic position and health is believed to be mediated, in part, by psycho-social comparison of one’s situation with that of others. But with whom? Possibilities include family, friends, elites, or even those in other countries or in previous times. So far, there has been almost no research on whether the reference point matters. New publication in International Jour

https://www.lupop.lu.se/article/compared-whom-reference-groups-socio-economic-comparisons-and-self-reported-health-34-countries - 2025-08-25

The ESC-EORP EURO-ENDO (European Infective Endocarditis) registry

The European Society of Cardiology (ESC) EURObservational Research Programme (EORP) European Endocarditis (EURO-ENDO) registry aims to study the care and outcomes of patients diagnosed with infective endocarditis (IE) and compare findings with recommendations from the 2015 ESC Clinical Practice Guidelines for the management of IE and data from the 2001 Euro Heart Survey. New publication in Europea

https://www.lupop.lu.se/article/esc-eorp-euro-endo-european-infective-endocarditis-registry - 2025-08-25

Weight and height separated provide better understanding than BMI on the risk of revision after total knee arthroplasty: report of 107,228 primary total knee arthroplasties from the Swedish Knee Arthroplasty Register 2009–2017

Obesity defined as increased BMI is commonly associated with higher revision rates following total knee arthroplasty (TKA). We examined the effect of BMI on the rate of revision after TKA, for both infection and other reasons, and analyzed weight and height separately to provide better understanding of the risk profile. New publication in Journal Acta Orthopaedica

https://www.lupop.lu.se/article/weight-and-height-separated-provide-better-understanding-bmi-risk-revision-after-total-knee - 2025-08-25

Genetic instrumental variable analysis: time to call mendelian randomization what it is. The example of alcohol and cardiovascular disease

In recent years, epidemiologists have increasingly sought to employ genetic data to identify ‘causal’ relationships between exposures of interest and various endpoints – an instrumental variable approach sometimes termed Mendelian randomization. However, this approach is subject to all of the limitations of instrumental variable analysis and to several limitations specific to its genetic underpinn

https://www.lupop.lu.se/article/genetic-instrumental-variable-analysis-time-call-mendelian-randomization-what-it-example-alcohol-and - 2025-08-25

Midlife physical activity is associated with lower incidence of vascular dementia but not Alzheimer’s disease

Physical activity might reduce the risk of developing dementia. However, it is still unclear whether the protective effect differs depending on the subtype of dementia. We aimed to investigate if midlife physical activity affects the development of vascular dementia (VaD) and Alzheimer’s disease (AD) differently in two large study populations with different designs. New publication in Alzheimer´s

https://www.lupop.lu.se/article/midlife-physical-activity-associated-lower-incidence-vascular-dementia-not-alzheimers-disease - 2025-08-25

How Independent Are “Independent” Effects? Relative Risk Estimation When Correlated Exposures Are Measured Imprecisely

A relative risk estimate which relates an exposure to risk of disease will tend to be estimated too close to unity if that exposure is subject to random measurement error or intra-subject variability. New publication in International Journal of Epidemiology

https://www.lupop.lu.se/article/how-independent-are-independent-effects-relative-risk-estimation-when-correlated-exposures-are - 2025-08-25

Förändringar i Socialstyrelsens klassifikationer

Från den 1/1 2020 sker en del ändringar i Socialstyrelsens klassifikationer vilket är viktigt för dig att veta som använder klassifikationer vid bl.a. statistik-, analys- och registerarbete. 1)      https://www.socialstyrelsen.se/utveckla-verksamhet/e-halsa/klassificering-och-koder/senaste-uppdateringar/  (Via denna länk hittas ändringar fr.o.m. 2020 i Pdf-format till klassifikationerna samt listo

https://www.lupop.lu.se/article/forandringar-i-socialstyrelsens-klassifikationer - 2025-08-25

The importance of clinical registries

Griffen and colleagues article on extrapolating information from national registries showcases the importance of clinical health registries in identifying relationships between factors that can lead to adverse health outcomes. As discussed by the authors, how this adds to the body of evidence is that it is identified that this population group (patients with alcohol consumption and associated self

https://www.lupop.lu.se/article/importance-clinical-registries - 2025-08-25

Establishing the Prevalence and Prevalence at Birth of Hemophilia in Males: A Meta-analytic Approach Using National Registries

Prevalence of hemophilia as a proportion of cases to the male population, prevalence of hemophilia at birth as a proportion of cases to live male births by year of birth, life expectancy disadvantage as a 1 − ratio of prevalence to prevalence at birth, and expected number of patients worldwide based on prevalence in high-income countries and prevalence at birth. New publication in Annals of Intern

https://www.lupop.lu.se/article/establishing-prevalence-and-prevalence-birth-hemophilia-males-meta-analytic-approach-using-national - 2025-08-25

PROs in the wild: Assessing the validity of patient reported outcomes in an electronic registry

Collecting Patient-Reported Outcomes (PROs) is an important way to get first-hand information by patients on the outcome of treatments and surgical procedure they have undergone, and hence about the quality of the care provided. However, the quality of PRO data cannot be given for granted and cannot be traced back to the dimensions of timeliness and completeness only. New publication in Computer M

https://www.lupop.lu.se/article/pros-wild-assessing-validity-patient-reported-outcomes-electronic-registry - 2025-08-25

How to Validate Data Quality in a Trauma Registry? The Helsinki Trauma Registry Internal Audit

Trauma registry data are used for analyzing and improving patient care, comparison of different units, and for research and administrative purposes. Data should therefore be reliable. The aim of this study was to audit the quality of the Helsinki Trauma Registry internally. We describe how to conduct a validation of a regional or national trauma registry and how to report the results in a readily

https://www.lupop.lu.se/article/how-validate-data-quality-trauma-registry-helsinki-trauma-registry-internal-audit - 2025-08-25