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Large-scale science research facilities, such as those for investigation into the smallest components of physical matter, often consist of buildings with quite extraordinary features as regards shape and scale. These architectures are semiotically interesting in several ways: they have extraordinary outer forms that reflect the their inner activities; they require forms of mediation and planning t

It is not known how ghrelin affects insulin secretion in human islets from patients with type 2 diabetes (T2D) or whether islet ghrelin expression or circulating ghrelin levels are altered in T2D. Here we sought out to identify the effect of ghrelin on insulin secretion in human islets and the impact of T2D on circulating ghrelin levels and on islet ghrelin cells. The effect of ghrelin on insulin

Gestational diabetes mellitus (GDM) is associated with poor pregnancy outcomes and increased long-term risk of metabolic diseases for both mother and child. In Tanzania, GDM prevalence increased from 0% in 1991 to 19.5% in 2016. Anaemia has been proposed to precipitate the pathogenesis of GDM. We aimed to examine the prevalence of GDM in a rural area of Tanzania with a high prevalence of anaemia a

Few germline mutations are known to affect lung cancer risk. We performed analyses of rare variants from 39,146 individuals of European ancestry and investigated gene expression levels in 7,773 samples. We find a large-effect association with an ATM L2307F (rs56009889) mutation in adenocarcinoma for discovery (adjusted Odds Ratio = 8.82, P = 1.18 × 10−15) and replication (adjusted OR = 2.93, P = 2

A growing body of evidence suggests that the dysregulation of neuronal iron may play a critical role in Alzheimer's disease. Recent MRI studies have established a relationship between iron accumulation and amyloid-β aggregation. The present study provides further insight demonstrating a relationship between iron and tau accumulation using magnetic resonance-based quantitative susceptibility mappin

The fresh-water cyanobacterium Microcystis is known to form blooms world-wide, and is often responsible for the production of microcystins found in lake water. Microcystins are non-ribosomal peptides with toxic effects, e.g. on vertebrates, but their function remains largely unresolved. Moreover, not all strains produce microcystins, and many different microcystin variants have been described. Her

Calling has gained importance in the career and organization scholarship as a key concept to better explain the meaningfulness of work from a humanistic perspective. On the contrary, much debate remains about the ways a calling–and the meaningfulness intertwined with it–can transform over time. To respond to this problem in the literature, we investigate the calling of corporate social responsibil

Solar access describes the capacity of urban spaces to receive sunlight and daylight. Rapid urbanization and unbridled densification pose a threat to sustainable solar access, reducing the penetration of sunlight and daylight into cities. To effectively assess solar access at such an early design stage, at the urban planning level, it is critical that evaluation metrics are simple and reliable. Th

Exocytosis in excitable cells is essential for their physiological functions. Although the exocytotic machinery controlling cellular secretion has been well investigated, the function of the vesicular cargo, i.e. secretory granular content remains obscure. Here we combine dSTORM imaging and single-domain insulin antibody, to dissect the in situ structure of insulin granule cores (IGCs) at nano lev

The European Union has a low-carbon roadmap that aims at reducing greenhouse gas emissions toprevent further climate change and achieve climate-neutrality by 2050. Many of the historical buildings that wehave today will still be around in 2050. Hence, there is a need to improve their energy performance. A way to dothis is to use hemp-lime as a material for renovation. Hemp shiv, the woody core par

Black carbon (BC), spheroidal carbonaceous particles (SCP), and polycyclic aromatic hydrocarbons (PAH) are carbonaceous pollutants affecting the climate, environment, and human health. International regulations limit their emissions, and the present emissions are followed by monitoring programs. However, the monitoring programs have limited spatio-temporal coverage and only span the last decades.

Background: Achieving lasting remission for at least 2 years is a good indicator for favourable prognosis long term after Diffuse large B-cell lymphoma (DLBCL). The aim of this study was to provide real-world probabilities, useful in risk communication and clinical decision-making, of the chance for lasting remissions by clinical characteristics. Methods: DLBCL patients in remission after primary

Today, the advances in airborne LIDAR technology provide high-resolution datasets that allow specialists to detect archaeological features hidden under wooded areas more efficiently. Still, the complexity and large scale of these datasets require automated analysis. In this respect, artificial intelligence (AI)-based analysis has recently created an alternative approach for interpreting remote sen

Recreational hunting evokes emotions and could be described as a contested space. The paper presents a study of recreational hunting in Sweden, focusing on accounts and narratives from ethnographic interviews with hunting tourism operators. It discusses how the notion of sustainability permeates and frames moral accounts of hunting practices, game meat, wildlife management, business ethics, animal