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Immune checkpoint inhibitors (ICIs), targeting checkpoint receptors such as programmed cell death protein 1 (PD-1), are associated with increased risk of cardiovascular events, but the underlying mechanisms remain poorly understood. Here we show that PD-1 + T cells from murine atherosclerotic aortas mainly display a progenitor exhausted phenotype (PD-1 intSlamf6 +Tim3 -), produce IFNγ in vivo, exh
Recessive diseases arise when both copies of a gene are impacted by a damaging genetic variant. When a patient carries two potentially causal variants in a gene, accurate diagnosis requires determining that these variants occur on different copies of the chromosome (that is, are in trans) rather than on the same copy (that is, in cis). However, current approaches for determining phase, beyond pare
Inhibition of adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK) is under increasing investigation for its therapeutic potential in many diseases. Existing AMPK inhibitors are however limited, with poor selectivity and substantial off-target effects. Here, we provide mechanistic insights and describe the cellular selectivity of the recently identified AMPK inhibitor BAY-3827. A 2.5-Å
This study protocol outlines the test evaluation of the design of a comprehensive Nordic hospital at home (HaH) digital education program entitled “the Nordic Digital Health and Education” program (NorDigHE). The NorDigHE program aims to prepare healthcare professionals for healthcare provision in a HaH context. The program, developed by a Nordic consortium, spans five modules over 3.5 weeks of fu
Research excellence instruments (REIs) are among the most popular types of research funding in several research systems, including the Global South. A significant proportion of REIs is intended to promote pathbreaking or groundbreaking contributions. Specific research outcomes can often be traced back to a given project’s scientific objectives, but projections about the impact on the field and the
There has been a growing interest in how workers in high-carbon industries are impacted by low-carbon transitions and how such transitions can be implemented in a way that is just. This study explores the socio-cultural dimensions of these processes, focusing on the role of identity in shaping workers’ perceptions of low-carbon transitions and their ability to navigate change. It does so through a
To secure sufficient, clean, and reliable drinking water amidst climate change, evolving land use, and population growth, artificial infiltration ponds are essential tools for drinking water providers in many areas. Optimizing their operation requires a detailed understanding of infiltration processes and subsurface water transport dynamics.At a Managed Aquifer Recharge (MAR) facility in southern
Ulnar nerve entrapment at the elbow (UNE) is the second most common compression neuropathy in the upper limb. Immediate return-to-work (RTW) after surgery is seldom possible due to restrictions and recovery demands. We aimed to explore RTW after UNE surgery and investigate factors contributing to variations. A prospective study with patients undergoing primary UNE surgery was conducted. Treatment
BACKGROUND: Sharp force injuries display varying patterns depending on the manner of death (homicide, suicide, accidental). The purpose of this study was to analyse forensic autopsy data to examine the characteristics of sharp force injuries on the extremities, to differentiate between different manners of death and to examine demographic differences.METHODS: This retrospective cohort study utiliz
Since 1955, a form of diabetes in lean, young (BMI <18·5 kg/m2, age <30 years) individuals with a history suggestive of undernutrition from before birth and throughout childhood has been described in the literature. In 1985, WHO formally classified it as malnutrition-related diabetes, but subsequently removed the classification in 1999 over a disagreement as to whether undernutrition was a suffici
Epithelial tissue fusion requires coordinated molecular events at the ends of two epithelial structures. Regulatory mechanisms controlling these events remain largely elusive. In the Drosophila reproductive system (RS), this fusion unites the gonad and the genital disc-derived tissues, into a continuous tube. This study unveils the pivotal role of Hamlet (Ham), a Drosophila PR domain containin
The retinoblastoma gene (RB1), which is located on chromosome 13q14.2, is mutated in retinoblastoma (RB), the most common malignant intraocular tumor in children. About 8000 new cases of retinoblastoma are diagnosed globally each year, accounting for approximately 1 in 17,000 live births. RB is prototypically considered hereditary by nature as thirty to forty percent of cases have autosomal domina
Adaptive reuse, the conversion of buildings for new functions, is gaining prominence for its cost-saving and environmental benefits. However, prior research primarily focuses on preserving the building envelope, often overlooking building services such as ventilation, which affect occupant well-being, costs, and environmental performance. This study explores a novel adaptive reuse approach by reus
Physical activity lowers risk of cardiovascular disease and may also decrease arterial stiffness. We aimed to investigate whether arterial stiffness can explain part of the association between physical activity and the risk of major adverse cardiovascular events (MACE) and all-cause death in men and women. We followed 2583 individuals from the Malmö Diet and Cancer study (2007-2012) for occurrence
Science is a risky business, and risk-taking is a critical disposition for scientists. This study uses a combination of survey and bibliometric data to measure the degree of individual scientists' risk-taking and investigate its determinants. In particular, we focus on academic training as a critical arena for the socialization of risk-taking and examine whether and how risk-taking is transmitted
This study assesses the feasibility of extracting high-quality DNA from blood samples stored at – 20 °C for up to 21 years under suboptimal conditions. It addresses sample mishandling in research, where many samples lack proper biobank protocols. Prior studies focused on short-term storage and controlled conditions, highlighting the negative effects of freeze–thaw cycles. This study evaluates whet
