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BACKGROUND: Low resting heart rate and premature atrial contractions (PACs) predict incident atrial fibrillation (AF) and could be interdependent, since PACs occur in the gaps between normal beats.OBJECTIVE: To study the association between low heart rate at 24hECG, PACs and incident AF in a prospective population-based cohort.METHODS: In the Malmö Diet and Cancer study, 24hECGs were performed in

Popular Abstract in Swedish Kliniska och experimentella studier av nickelallergi Nickelallergi är vanligt, särskilt hos kvinnor. Nickelallergi leder ofta till periodiskt eller kroniskt eksem, främst på händerna. Dessa eksem kan vara svårläkta och leda till långa sjukskrivningsperioder. Nickel finns överallt i omgivningen och det går inte att helt undvika exposition för denna metall. Syftet med dKliniska och experimentella studier av nickelallergi Nickelallergi är vanligt, särskilt hos kvinnor. Nickelallergi leder ofta till periodiskt eller kroniskt eksem, främst på händerna. Dessa eksem kan vara svårläkta och leda till långa sjukskrivningsperioder. Nickel finns överallt i omgivningen och det går inte att helt undvika exposition för denna metall. Clinical and experimental studies in nic

The 68-kDa homodimeric 3C-like protease of SARS-CoV-2, Mpro (3CLpro/Nsp5), is a promising antiviral drug target. We evaluate the concordance of models generated by the newly introduced AlphaFold2 structure prediction program with residual dipolar couplings (RDCs) measured in solution for 15N-1HN and 13C′-1HN atom pairs. The latter were measured using a new, highly precise TROSY-AntiTROSY Encoded R

“Tin-oxo cage” organometallic compounds are considered as photoresists for extreme ultraviolet (EUV) photolithography. To gain insight into their electronic structure and reactivity to ionizing radiation, we trapped bare gas-phase n-butyltin-oxo cage dications [(BuSn)12O14(OH)6]2+ in an ion trap and investigated their fragmentation upon soft X-ray photoabsorption by means of mass spectrometry. In

Background: Irradiation with violet-blue light (VBL), in the spectrum of 405–450 nm, has been reported to be effective against pathogenic bacteria. Aim: To investigate whether VBL irradiation could reduce the level of surface contamination at seven shared patient bathrooms in two wards at a hospital in Sweden. Methods: Repeated sampling of five separate surfaces (door handle, tap water handle, flo

Backround: We wanted to characterize conditional survival in prostate cancer (PC) in Sweden around and after 2005 when the vast increase in incidence due to the opportunistic testing for prostate specific antigen (PSA) culminated. We hypothesize that analyzing survival data during that time period may help interpret survival trends. We focus on stage-specific analysis using conditional survival in

Background: The COVID-19 pandemic has disrupted routine hospital services globally. This study estimated the total number of adult elective operations that would be cancelled worldwide during the 12 weeks of peak disruption due to COVID-19.Methods: A global expert response study was conducted to elicit projections for the proportion of elective surgery that would be cancelled or postponed during t

Elsparkcyklarna sprider sig, inte bara inom Lund utan över hela jorden. Därför växer även behovet av säkrare och mer hållbara batterier. Batteriets hölje är särskilt kritiskt för att skydda batteriet mot stötar, värme och elektromagnetism. Detta examensarbete fokuserade på just detta hölje och om det är rimligt att 3D-printa det. Genom ett omfattande designprojekt mynnade arbetet slutligen ut i koThe aim of this project was to explore battery enclosures, specifically for e-scooter batteries, and whether additive manufacturing can be used to enhance existing designs. Furthermore, FEM and topology optimization were explored as tools for optimizing these designs. A modified Double Diamond approach was used as a guideline for the project. The modified version enters a prolonged optimization p

Background: The major adverse effect of warfarin treatment is hemorrhage. Several risk factors for bleeding complications are also risk factors for thromboembolic events, making the clinical decision to initiate or withhold anticoagulant treatment difficult. Specific markers that solely identify patients at high risk of bleeding would have great clinical impact. This study aimed to test if thrombo

Aberrant expression of several key regulators controlling the G1/S phase of the cell cycle has been implicated in human male germ cell tumorigenesis. Given the critical role of cyclin A2 at both the G1/S and G2/M transitions and the essential role for cyclin A1 in male germ cell development, our present study focused on the involvement of the A-type cyclins in the transformation and progression of

Arbuscular mycorrhizal (AM) mycelia are dependent on contact with plant roots for spore formation. In this study, earthworms and collembolans were regarded as potential dispersal vectors of AM fungal spores and hyphae, and we determined how they influenced the extension of AM fungi from host plant roots. Plantago lanceolata seedlings were grown in a mesh bag with an AM inoculurn of dried soil and

Purpose: To determine whether a short-term, problem-based educational intervention leads to increased research activity among health care practitioners. Subjects and Methods: Participant's success was evaluated as a composite of 2 outcomes. These were (1) reporting results for the project designed during the practicum and (2) conducting subsequent research activities. The study population included

Objective: To evaluate how often low 5-min Apgar scores (AS(5-min)) at term are associated with asphyxia. Study design: A cohort- and case-control study, including all 183 term infants with AS(5-min) below 7 born at Lund University Hospital during 1993-2002, antepartum deaths excluded. The control group included 183 randomly selected term newborns with AS(5-min) 9-10. Cardiotocography (CTG) traces

We investigated whether exposure of rat brain to microwaves (MWs) of global system for mobile communication (GSM) induces DNA breaks, changes in chromatin conformation and in gene expression. An exposure installation was used based on a test mobile phone employing a GSM signal at 915 MHz, all standard modulations included, output power level in pulses 2 W, specific absorption rate (SAR) 0.4 mW/g.

Background More than 1100 mutations that cause hemophilia B (HB) have been identified. At the same time, specific F9 mutations are present at high frequencies in certain populations, which raise questions about the origin of HB mutations. ObjectivesTo describe the mutation spectrum of all HB families in Sweden and investigate if mutations appearing in several families are due to independent recurr

1 Heidelberg University LERU Doctoral Summer School in Heidelberg 2023 Concepts of intervention science applied to global challenges Equipping the next generation of scientists with understanding of main concepts and methods of intervention science and applying them to the converging global challenges: climate change, pandemics, and societal injustice “What starts out as science fiction today may

https://www.staff.lu.se/sites/staff.lu.se/files/2023-03/LERU%20Doctoral%20Summer%20School%202023%20Heidelberg%20UPDATED%20PROGRAM.pdf - 2026-05-06

Autoantibodies against glutamic acid decarboxylase 65 (GADA) are found frequently in patients with autoimmune diabetes. Immunoglobulin (Ig)G(1) is the most frequent subclass among the GADA IgG subclasses. IgG(4) is a more common subclass in latent autoimmune diabetes in adults (LADA) at clinical onset compared to type 1 diabetes. The aim of this work was to study the different GADA-IgG subclass pr

Popular Abstract in Swedish Medfödda hjärtfel (congenital heart defects,CHD) förekommer hos nästan 1 % av alla födda barn. En del lindriga hjärtfel spontanläker, men de flesta hjärtfel måste opereras i läkande eller lindrande syfte. Stora kirurgiska framsteg har gjorts på senare år. Hjärtfel som tidigare icke ansågs möjliga att åtgärda kan nu opereras, och många operationer utföres tidigt i livet,The aim of this study was to evaluate new MR techniques permitting qualitative and quantitative analysis of cardiac function and measurement of velocity and flow, and later on contrast-enhanced MR angiography, techniques largely unexplored in children with CHD. Infants with tetralogy of Fallot and pulmonary atresia with ventricular septal defect were examined pre-operatively. MRI was found to be a

Polymer dispersions are employed in a wide variety of applications as film formers. Especially in the coating-, paint-, pharmaceutical and hygiene industry polymer dispersions are to a large extent used as barriers, controlled-release agents and adhesives. Control and steering of the polymerization process has resulted in the production of core-shell structures with soft and hard (low glass transi